Depleted Hexokinase1 and lack of AMPKα activation favor OXPHOS-dependent energetics in Retinoblastoma tumors.

[1]  Arkasubhra Ghosh,et al.  Selective Induction of Intrinsic Apoptosis in Retinoblastoma Cells by Novel Cationic Antimicrobial Dodecapeptides , 2022, Pharmaceutics.

[2]  R. Shetty,et al.  Lack of Retinoblastoma Protein Shifts Tumor Metabolism from Glycolysis to OXPHOS and Allows the Use of Alternate Fuels , 2022, Cells.

[3]  R. Shetty,et al.  Integrated Analysis of Cancer Tissue and Vitreous Humor from Retinoblastoma Eyes Reveals Unique Tumor-Specific Metabolic and Cellular Pathways in Advanced and Non-Advanced Tumors , 2022, Cells.

[4]  C. Lindsley,et al.  Evaluation of intravitreal topotecan dose levels, toxicity and efficacy for retinoblastoma vitreous seeds: a preclinical and clinical study , 2021, British Journal of Ophthalmology.

[5]  J. Pierce,et al.  Complete preclinical platform for intravitreal chemotherapy drug discovery for retinoblastoma: Assessment of pharmacokinetics, toxicity and efficacy using a rabbit model , 2021, MethodsX.

[6]  C. Besirli,et al.  Photoreceptor metabolic reprogramming: current understanding and therapeutic implications , 2021, Communications Biology.

[7]  Y. Ohe,et al.  RB1 loss induced small cell lung cancer transformation as acquired resistance to pembrolizumab in an advanced NSCLC patient. , 2020, Lung cancer.

[8]  J. Shim,et al.  Synthetic lethality of RB1 and aurora A is driven by stathmin-mediated disruption of microtubule dynamics , 2020, Nature Communications.

[9]  J. Hurley,et al.  Daily mitochondrial dynamics in cone photoreceptors , 2020, Proceedings of the National Academy of Sciences.

[10]  Nikos Koundouros,et al.  Reprogramming of fatty acid metabolism in cancer , 2019, British Journal of Cancer.

[11]  A. Balmain,et al.  KRAS4A Directly Regulates Hexokinase 1 , 2019, Nature.

[12]  C. Shields,et al.  Retinoblastoma vascular perfusion and intra‐arterial chemotherapy cycle requirements , 2019, Clinical & experimental ophthalmology.

[13]  E. Andrechek,et al.  E2F1 Drives Breast Cancer Metastasis by Regulating the Target Gene FGF13 and Altering Cell Migration , 2019, Scientific Reports.

[14]  J. Sage,et al.  RB1 Deletion in Retinoblastoma Protein Pathway-Disrupted Cells Results in DNA Damage and Cancer Progression , 2019, Molecular and Cellular Biology.

[15]  Karthik Raman,et al.  Metabolite systems profiling identifies exploitable weaknesses in retinoblastoma , 2018, FEBS letters.

[16]  S. Goel,et al.  CDK4/6 Inhibition in Cancer: Beyond Cell Cycle Arrest. , 2018, Trends in cell biology.

[17]  D. Stuart,et al.  Lentiviral transduction of mammalian cells for fast, scalable and high-level production of soluble and membrane proteins , 2018, Nature Protocols.

[18]  C. Craft,et al.  Developmental stage-specific proliferation and retinoblastoma genesis in RB-deficient human but not mouse cone precursors , 2018, Proceedings of the National Academy of Sciences of the United States of America.

[19]  E. Solary,et al.  Biallelic inactivation of the retinoblastoma gene results in transformation of chronic myelomonocytic leukemia to a blastic plasmacytoid dendritic cell neoplasm: shared clonal origins of two aggressive neoplasms , 2018, Blood Cancer Journal.

[20]  J. Sage,et al.  Non-canonical functions of the RB protein in cancer , 2018, Nature Reviews Cancer.

[21]  Jared E. Toettcher,et al.  Four Key Steps Control Glycolytic Flux in Mammalian Cells. , 2018, Cell systems.

[22]  C. Punzo,et al.  Aerobic Glycolysis Is Essential for Normal Rod Function and Controls Secondary Cone Death in Retinitis Pigmentosa , 2018, Cell reports.

[23]  A. Agrawal,et al.  Role of Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography in Various Orbital Malignancies , 2018, Indian journal of nuclear medicine : IJNM : the official journal of the Society of Nuclear Medicine, India.

[24]  Shenmin Zhang,et al.  Retinal de novo lipogenesis coordinates neurotrophic signaling to maintain vision , 2018, JCI insight.

[25]  L. Galluzzi,et al.  Mitochondrial metabolism and cancer , 2017, Cell Research.

[26]  U. Nir,et al.  Mitochondrial OXPHOS Induced by RB1 Deficiency in Breast Cancer: Implications for Anabolic Metabolism, Stemness, and Metastasis. , 2017, Trends in cancer.

[27]  Yingbin Xiao,et al.  AMPK activation serves a critical role in mitochondria quality control via modulating mitophagy in the heart under chronic hypoxia , 2017, International journal of molecular medicine.

[28]  Xianjie Sun,et al.  E2F1 silencing inhibits migration and invasion of osteosarcoma cells via regulating DDR1 expression , 2017, International journal of oncology.

[29]  M. Atkinson,et al.  The Rb1 tumour suppressor gene modifies telomeric chromatin architecture by regulating TERRA expression , 2017, Scientific Reports.

[30]  C. Cepko,et al.  Glycolytic reliance promotes anabolism in photoreceptors , 2017, bioRxiv.

[31]  N. Dyson RB1: a prototype tumor suppressor and an enigma , 2016, Genes & development.

[32]  Xiaojian Wu,et al.  Overexpression of Hexokinase 1 as a poor prognosticator in human colorectal cancer , 2016, Tumor Biology.

[33]  J. Hurley,et al.  Glucose, lactate, and shuttling of metabolites in vertebrate retinas , 2015, Journal of neuroscience research.

[34]  M. Villanueva Tumorigenesis: Establishing the origin of retinoblastoma , 2014, Nature Reviews. Cancer.

[35]  S. Jhanwar,et al.  Rb suppresses human cone precursor-derived retinoblastoma tumors , 2014, Nature.

[36]  J. Sage,et al.  Cancer: The origin of human retinoblastoma , 2014, Nature.

[37]  Daniel J. Mount,et al.  Abnormal partitioning of hexokinase 1 suggests disruption of a glutamate transport protein complex in schizophrenia , 2014, Schizophrenia Research.

[38]  Yoichi Taya,et al.  Cytoplasmic translocation of the retinoblastoma protein disrupts sarcomeric organization , 2013, eLife.

[39]  N. Dyson,et al.  The multiple connections between pRB and cell metabolism. , 2013, Current opinion in cell biology.

[40]  D. Vitkup,et al.  Heterogeneity of tumor-induced gene expression changes in the human metabolic network , 2013, Nature Biotechnology.

[41]  M. V. Vander Heiden,et al.  Allosteric Regulation of PKM2 Allows Cellular Adaptation to Different Physiological States , 2013, Science Signaling.

[42]  B. Morio,et al.  Importance of metabolic changes induced by chemotherapy on prognosis of early‐stage breast cancer patients: a review of potential mechanisms , 2012, Obesity reviews : an official journal of the International Association for the Study of Obesity.

[43]  Rakesh Kumar,et al.  Role of PET/CT in Staging and Evaluation of Treatment Response After 3 Cycles of Chemotherapy in Locally Advanced Retinoblastoma: A Prospective Study , 2012, The Journal of Nuclear Medicine.

[44]  J. Tovey,et al.  AAV serotype influences gene transfer in corneal stroma in vivo. , 2010, Experimental eye research.

[45]  W. Winder,et al.  AMP‐activated protein kinase control of fat metabolism in skeletal muscle , 2009, Acta physiologica.

[46]  V. Shoshan-Barmatz,et al.  Voltage-dependent Anion Channel 1-based Peptides Interact with Hexokinase to Prevent Its Anti-apoptotic Activity* , 2009, Journal of Biological Chemistry.

[47]  A. Giordano,et al.  RB and cell cycle progression , 2006, Oncogene.

[48]  F. Luo,et al.  Hypoxia-inducible transcription factor-1α promotes hypoxia-induced A549 apoptosis via a mechanism that involves the glycolysis pathway , 2006, BMC Cancer.

[49]  R. DePinho,et al.  The Kinase LKB1 Mediates Glucose Homeostasis in Liver and Therapeutic Effects of Metformin , 2005, Science.

[50]  K. Ichimura,et al.  Mutations in Rb1 pathway-related genes are associated with poor prognosis in Anaplastic Astrocytomas , 2005, British Journal of Cancer.

[51]  B. Brüne,et al.  Retinoblastoma susceptibility gene product pRB activates hypoxia-inducible factor-1 (HIF-1) , 2005, Oncogene.

[52]  B. Gallie,et al.  Chemotherapy for retinoblastoma. , 2005, Ophthalmology clinics of North America.

[53]  Jérôme Boudeau,et al.  LKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK/PAR‐1 , 2004, The EMBO journal.

[54]  John Eric Wilson Isozymes of mammalian hexokinase: structure, subcellular localization and metabolic function , 2003, Journal of Experimental Biology.

[55]  L. Witters,et al.  Acetyl-CoA carboxylase regulation of fatty acid oxidation in the heart. , 1993, The Journal of biological chemistry.

[56]  Stephen H. Friend,et al.  A human DNA segment with properties of the gene that predisposes to retinoblastoma and osteosarcoma , 1986, Nature.

[57]  Matthew W. Wilson,et al.  Ocular Salvage and Vision Preservation Using a Topotecan-Based Regimen for Advanced Intraocular Retinoblastoma. , 2017, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[58]  Cone precursor cells are the cell-of-origin in retinoblastoma. , 2014, Cancer discovery.

[59]  S. Wakil,et al.  Fatty acid metabolism: target for metabolic syndrome This work is supported by grants from the National Institute of Health (GM-63115), the Hefni Technical Training Foundation, and the Medallion Foundation. Published, JLR Papers in Press, December 1, 2008. , 2009, Journal of Lipid Research.