The contribution of cholinergic detrusor excitation in a pig model of bladder hypocompliance

Objective To investigate the role of cholinergic excitation in mediating changes in detrusor compliance (manifested on conventional cystometry as an incremental rise in detrusor pressure as bladder volume increases) under conditions of propofol‐sedation in the pig.

[1]  A. Brading.  A myogenic basis for the overactive bladder. , 1997, Urology.

[2]  J Sellgren,et al.  Sympathetic Muscle Nerve Activity, Peripheral Blood Flows, and Baroreceptor Reflexes in Humans during Propofol Anesthesia and Surgery , 1994, Anesthesiology.

[3]  K. Anderson.  Pharmacology of lower urinary tract smooth muscles and penile erectile tissues. , 1993, Pharmacological reviews.

[4]  M. Cohen,et al.  Propofol: an alternative general anesthetic for outpatient oral surgery. , 1996, Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons.

[5]  J. Duckett,et al.  Is lamina propria matrix responsible for normal bladder compliance? , 1992, The Journal of urology.

[6]  A. F. Brading,et al.  Cause of low compliance in a guinea‐pig model of instability and low compliance , 1992 .

[7]  A. Wein,et al.  Relevance of spontaneous activity to urinary bladder function: an in vitro and in vivo study. , 1986, The Journal of urology.

[8]  W. C. Groat.  A neurologic basis for the overactive bladder , 1997 .

[9]  F. Barrington.  THE NERVOUS MECHANISM OF MICTURITION , 1914 .

[10]  R. Barnard,et al.  Morphological and morphometric studies of the human obstructed, trabeculated urinary bladder. , 1985, British journal of urology.

[11]  B. Coolsaet,et al.  New concepts in relation to urge and detrusor activity , 1993, Neurourology and urodynamics.

[12]  G N Sibley,et al.  A comparison of spontaneous and nerve‐mediated activity in bladder muscle from man, pig and rabbit. , 1984, The Journal of physiology.

[13]  R. Levin,et al.  Effects of hypoxia, calcium, carbachol, atropine and tetrodotoxin on the filling of the in-vitro rabbit whole bladder. , 1998, The Journal of urology.

[14]  S. Tsuchida.  [Nervous control of micturition]. , 1989, Nihon Hinyokika Gakkai zasshi. The japanese journal of urology.

[15]  W. D. de Groat,et al.  A neurologic basis for the overactive bladder. , 1997, Urology.

[16]  D. Coplen,et al.  Developmental changes in normal fetal bovine whole bladder physiology. , 1994, The Journal of urology.

[17]  A. Brading,et al.  Urinary bladder blood flow changes during the micturition cycle in a conscious pig model. , 1996, The Journal of urology.

[18]  P. Doyle,et al.  The effects of drugs and anaesthetic agents on the urinary bladder and sphincters. , 1976, British journal of urology.

[19]  T. M. Ramsay,et al.  An In‐vitro Study of the Interactions Between Intravenous Induction Agents and the Calcium Antagonists Verapamil and Nifedipine , 1989, The Journal of pharmacy and pharmacology.

[20]  T. B. Kuo,et al.  Spectral Analysis of Arterial Pressure Variability During Induction of Propofol Anesthesia , 1996, Anesthesia and analgesia.

[21]  L. Fleisher,et al.  Changes in Heart Rate Variability Under Propofol Anesthesia: A Possible Explanation for Propofol‐Induced Bradycardia , 1994, Anesthesia and analgesia.