Factors predicting atracurium reversal time

Background: To identify individual factors and combination of factors predictive of reversal time (defined as time from neostigmine administration to train‐of‐four (TOF) ratio 0.70) from atracurium‐induced neuromuscular block, the present study tested the following variables as possible predictors of reversal time: 1) degree of block at the time of antagonism as quantified by first response to TOF or double‐burst stimulation (DBS); 2) time from last supplemental dose of atracurium to administration of neostigmine (pre‐reversal time); and 3) time from administration of initial atracurium dose to T1 (the magnitude of the first twitch in TOF) recovered to 10% (duration of action of the initial dose of atracurium).

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