DIFFERENTIAL PULSE POLAROGRAPHIC DETERMINATION OF NIFEDIPINE IN PHARMACEUTICAL FORMULATIONS

A simple and rapid differential pulse polarographic method has been developed for the trace determination of Nifedipine. A well-defined single peak with Ep value of -0.51 V is obtained in 0.1M acetate buffer (pH 5.0). The linearity is valid up to 5×10 -5 M (r =0.9995) with minimum detection limit of 3.5×10 -8 M. Precision of the method developed is implied from the values of relative mean deviation, standard deviation and coefficient of variation, which are 2.05%, 1.1 and 3.2% respectively. Marketed formulations of Nifedipine have been analyzed by calibration and standard addition methods. Recovery experiments have been found to be quantitative and analysis to determine the mass per tablet is obtained within ± 0.2% of the expected value. The studies have shown that the method is simple, reproducible and accurate and can be used in the analysis of marketed formulations.