Exome sequencing of serous endometrial tumors identifies recurrent somatic mutations in chromatin-remodeling and ubiquitin ligase complex genes

[1]  Tian-Li Wang,et al.  Identification of molecular pathway aberrations in uterine serous carcinoma by genome-wide analyses. , 2012, Journal of the National Cancer Institute.

[2]  Thomas Zeng,et al.  Use of mutation profiles to refine the classification of endometrial carcinomas , 2012, The Journal of pathology.

[3]  Keith A. Boroevich,et al.  Whole-genome sequencing of liver cancers identifies etiological influences on mutation patterns and recurrent mutations in chromatin regulators , 2012, Nature Genetics.

[4]  Bin Tean Teh,et al.  Exome sequencing of liver fluke–associated cholangiocarcinoma , 2012, Nature Genetics.

[5]  S. Imbeaud,et al.  Integrated analysis of somatic mutations and focal copy-number changes identifies key genes and pathways in hepatocellular carcinoma , 2012, Nature Genetics.

[6]  A. Sivachenko,et al.  Exome sequencing identifies recurrent SPOP, FOXA1 and MED12 mutations in prostate cancer , 2012, Nature Genetics.

[7]  Benjamin J. Raphael,et al.  The Mutational Landscape of Lethal Castrate Resistant Prostate Cancer , 2016 .

[8]  Tadashi Kaname,et al.  New from NPG , 2012, Nature Medicine.

[9]  S. Ramaswamy,et al.  Systematic identification of genomic markers of drug sensitivity in cancer cells , 2012, Nature.

[10]  Yves Moreau,et al.  Heterozygous missense mutations in SMARCA2 cause Nicolaides-Baraitser syndrome , 2012, Nature Genetics.

[11]  Eric D. Green,et al.  VarSifter: Visualizing and analyzing exome-scale sequence variation data on a desktop computer , 2012, Bioinform..

[12]  David T. W. Jones,et al.  Driver mutations in histone H3.3 and chromatin remodelling genes in paediatric glioblastoma , 2012, Nature.

[13]  Zhengyan Kan,et al.  Exome sequencing identifies frequent mutation of ARID1A in molecular subtypes of gastric cancer , 2011, Nature Genetics.

[14]  Tian-Li Wang,et al.  ARID1A, a factor that promotes formation of SWI/SNF-mediated chromatin remodeling, is a tumor suppressor in gynecologic cancers. , 2011, Cancer research.

[15]  Huanming Yang,et al.  Frequent mutations of chromatin remodeling genes in transitional cell carcinoma of the bladder , 2011, Nature Genetics.

[16]  P. Wade,et al.  Cancer biology and NuRD: a multifaceted chromatin remodelling complex , 2011, Nature Reviews Cancer.

[17]  C. Sander,et al.  Predicting the functional impact of protein mutations: application to cancer genomics , 2011, Nucleic acids research.

[18]  S. Wiseman,et al.  Loss of BAF250a (ARID1A) is frequent in high‐grade endometrial carcinomas , 2011, The Journal of pathology.

[19]  D. Sgroi,et al.  PIK3R1 (p85α) is somatically mutated at high frequency in primary endometrial cancer. , 2011, Cancer research.

[20]  I. Shih,et al.  Mutation and Loss of Expression of ARID1A in Uterine Low-grade Endometrioid Carcinoma , 2011, The American journal of surgical pathology.

[21]  B. O’Malley,et al.  Tumor Suppressor Role for the SPOP Ubiquitin Ligase in Signal-Dependent Proteolysis of the Oncogenic Coactivator SRC-3/AIB1 , 2011, Oncogene.

[22]  A. Mes-Masson,et al.  Subtype‐specific mutation of PPP2R1A in endometrial and ovarian carcinomas , 2011, The Journal of pathology.

[23]  V. Velculescu,et al.  Somatic mutations of PPP2R1A in ovarian and uterine carcinomas. , 2011, The American journal of pathology.

[24]  Michael A. Choti,et al.  DAXX/ATRX, MEN1, and mTOR Pathway Genes Are Frequently Altered in Pancreatic Neuroendocrine Tumors , 2011, Science.

[25]  Adam R. Johnson,et al.  Sensitivity to antitubulin chemotherapeutics is regulated by MCL1 and FBW7 , 2011, Nature.

[26]  G. Crabtree,et al.  ATP-dependent chromatin remodeling: genetics, genomics and mechanisms , 2011, Cell Research.

[27]  Zev A. Binder,et al.  The Genetic Landscape of the Childhood Cancer Medulloblastoma , 2011, Science.

[28]  D. Sgroi,et al.  A Unique Spectrum of Somatic PIK3CA (p110α) Mutations Within Primary Endometrial Carcinomas , 2011, Clinical Cancer Research.

[29]  Manuel Hidalgo,et al.  Convergent structural alterations define SWItch/Sucrose NonFermentable (SWI/SNF) chromatin remodeler as a central tumor suppressive complex in pancreatic cancer , 2011, Proceedings of the National Academy of Sciences.

[30]  C. Mathers,et al.  Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008 , 2010, International journal of cancer.

[31]  P. A. Futreal,et al.  Exome sequencing identifies frequent mutation of the SWI/SNF complex gene PBRM1 in renal carcinoma , 2010, Nature.

[32]  Richard A. Moore,et al.  ARID1A mutations in endometriosis-associated ovarian carcinomas. , 2010, The New England journal of medicine.

[33]  S. Elledge,et al.  A chromatin localization screen reveals poly (ADP ribose)-regulated recruitment of the repressive polycomb and NuRD complexes to sites of DNA damage , 2010, Proceedings of the National Academy of Sciences.

[34]  Tian-Li Wang,et al.  Frequent Mutations of Chromatin Remodeling Gene ARID1A in Ovarian Clear Cell Carcinoma , 2010, Science.

[35]  Jamie K Teer,et al.  Systematic comparison of three genomic enrichment methods for massively parallel DNA sequencing. , 2010, Genome research.

[36]  D. H. Larsen,et al.  The chromatin-remodeling factor CHD4 coordinates signaling and repair after DNA damage , 2010, The Journal of cell biology.

[37]  H. Vrolijk,et al.  The NuRD chromatin–remodeling complex regulates signaling and repair of DNA damage , 2010, The Journal of cell biology.

[38]  S. Jackson,et al.  Regulation of DNA-damage responses and cell-cycle progression by the chromatin remodelling factor CHD4 , 2010, The EMBO journal.

[39]  Gurpreet W. Tang,et al.  Systematic sequencing of renal carcinoma reveals inactivation of histone modifying genes , 2009, Nature.

[40]  L. Ellenson,et al.  Molecular alterations of EGFR and PIK3CA in uterine serous carcinoma. , 2009, Gynecologic oncology.

[41]  Brad T. Sherman,et al.  Bioinformatics enrichment tools: paths toward the comprehensive functional analysis of large gene lists , 2008, Nucleic acids research.

[42]  Kristian Cibulskis,et al.  Drug-sensitive FGFR2 mutations in endometrial carcinoma , 2008, Proceedings of the National Academy of Sciences.

[43]  Koji Ueno,et al.  Aneuploidy Predicts Outcome in Patients with Endometrial Carcinoma and Is Related to Lack of CDH13 Hypermethylation , 2008, Clinical Cancer Research.

[44]  S A Forbes,et al.  The Catalogue of Somatic Mutations in Cancer (COSMIC) , 2008, Current protocols in human genetics.

[45]  B. Clurman,et al.  FBW7 ubiquitin ligase: a tumour suppressor at the crossroads of cell division, growth and differentiation , 2008, Nature Reviews Cancer.

[46]  Guy Cavet,et al.  Comment on "The Consensus Coding Sequences of Human Breast and Colorectal Cancers" , 2007, Science.

[47]  Yu Li,et al.  Genomic and functional evidence for an ARID1A tumor suppressor role , 2007, Genes, chromosomes & cancer.

[48]  P. Georgel,et al.  CHD proteins: a diverse family with strong ties. , 2007, Biochemistry and cell biology = Biochimie et biologie cellulaire.

[49]  G. Parmigiani,et al.  The Consensus Coding Sequences of Human Breast and Colorectal Cancers , 2006, Science.

[50]  M. Hendrickson,et al.  Uterine papillary serous and clear cell carcinomas predict for poorer survival compared to grade 3 endometrioid corpus cancers , 2006, British Journal of Cancer.

[51]  J. Cigudosa,et al.  Cyclin E gene (CCNE) amplification and hCDC4 mutations in endometrial carcinoma , 2003, The Journal of pathology.

[52]  S. Reed,et al.  hCDC4 gene mutations in endometrial cancer. , 2002, Cancer research.

[53]  Weidong Wang,et al.  Specific targeting and constitutive association of histone deacetylase complexes during transcriptional repression. , 2002, Genes & development.

[54]  Rosanna Weksberg,et al.  Mutant chromatin remodeling protein SMARCAL1 causes Schimke immuno-osseous dysplasia , 2002, Nature Genetics.

[55]  M. Beckmann,et al.  Gene Amplification and Expression of the Steroid Receptor Coactivator SRC3 (AIB1) in Sporadic Breast and Endometrial Carcinomas , 2001, Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme.

[56]  M. Sherman Theories of Endometrial Carcinogenesis: A Multidisciplinary Approach , 2000, Modern Pathology.

[57]  Weidong Wang,et al.  NURD, a novel complex with both ATP-dependent chromatin-remodeling and histone deacetylase activities. , 1998, Molecular cell.

[58]  S. Schreiber,et al.  Chromatin deacetylation by an ATP-dependent nucleosome remodelling complex , 1998, Nature.

[59]  D. Reinberg,et al.  The Dermatomyositis-Specific Autoantigen Mi2 Is a Component of a Complex Containing Histone Deacetylase and Nucleosome Remodeling Activities , 1998, Cell.

[60]  B. Howard,et al.  The Transcriptional Coactivators p300 and CBP Are Histone Acetyltransferases , 1996, Cell.

[61]  R. Kempson,et al.  Uterine papillary serous carcinoma: A highly malignant form of endometrial adenocarcinoma , 1982, The American journal of surgical pathology.

[62]  Brad T. Sherman,et al.  Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources , 2008, Nature Protocols.

[63]  Y. Benjamini,et al.  Controlling the false discovery rate: a practical and powerful approach to multiple testing , 1995 .