Activation-Induced Cytidine Deaminase Correlates with Decreased E 47 and Reduced Ig Class Switch in Aged Mice

[1]  B. Blomberg,et al.  Age-related differences in the E2A-encoded transcription factor E47 in bone marrow-derived B cell precursors and in splenic B cells , 2004, Experimental Gerontology.

[2]  U. Storb,et al.  The E box motif CAGGTG enhances somatic hypermutation without enhancing transcription. , 2003, Immunity.

[3]  A. Fischer,et al.  Hyper-IgM syndrome type 4 with a B lymphocyte-intrinsic selective deficiency in Ig class-switch recombination. , 2003, The Journal of clinical investigation.

[4]  C. Murre,et al.  E-proteins directly regulate expression of activation-induced deaminase in mature B cells , 2003, Nature Immunology.

[5]  T. Kodera,et al.  Expression of activation‐induced cytidine deaminase decreases throughout the life , 2003, Journal of cellular and molecular medicine.

[6]  B. Blomberg,et al.  Effects of aging on proliferation and E47 transcription factor activity induced by different stimuli in murine splenic B cells , 2003, Mechanisms of Ageing and Development.

[7]  G. Kelsoe,et al.  Enhanced Differentiation of Splenic Plasma Cells but Diminished Long-Lived High-Affinity Bone Marrow Plasma Cells in Aged Mice 1 , 2003, The Journal of Immunology.

[8]  B. Blomberg,et al.  Decreased E12 and/or E47 Transcription Factor Activity in the Bone Marrow As Well As in the Spleen of Aged Mice1 , 2003, The Journal of Immunology.

[9]  J. Katz,et al.  Cutting Edge: Impaired Toll-Like Receptor Expression and Function in Aging , 2002, The Journal of Immunology.

[10]  S. Tangye,et al.  Isotype Switching by Human B Cells Is Division-Associated and Regulated by Cytokines1 , 2002, The Journal of Immunology.

[11]  R. Geha,et al.  The binding site for TRAF2 and TRAF3 but not for TRAF6 is essential for CD40-mediated immunoglobulin class switching. , 2002, Immunity.

[12]  Walther Parson,et al.  Lack of Antibody Production Following Immunization in Old Age: Association with CD8+CD28− T Cell Clonal Expansions and an Imbalance in the Production of Th1 and Th2 Cytokines1 , 2002, The Journal of Immunology.

[13]  C. Murre,et al.  IL‐7Rα and E47: independent pathways required for development of multipotent lymphoid progenitors , 2002, The EMBO journal.

[14]  E. Gardner,et al.  Role of humoral and cell-mediated immunity in protection from influenza disease after immunization of healthy elderly , 2002, Experimental Gerontology.

[15]  C. Murre,et al.  The regulation and function of the Id proteins in lymphocyte development , 2001, Oncogene.

[16]  A. Durandy.  Hyper-IgM syndromes: a model for studying the regulation of class switch recombination and somatic hypermutation generation. , 2001, Biochemical Society transactions.

[17]  T. Sata,et al.  Immune responses and protection in different strains of aged mice immunized intranasally with an adjuvant-combined influenza vaccine. , 2001, Vaccine.

[18]  D. Frasca,et al.  Role of DNA-dependent protein kinase in recognition of radiation-induced DNA damage in human peripheral blood mononuclear cells. , 2001, International immunology.

[19]  C. Murre,et al.  Regulation of the helix-loop-helix proteins, E2A and Id3, by the Ras-ERK MAPK cascade , 2001, Nature Immunology.

[20]  T. Honjo,et al.  Class Switch Recombination and Hypermutation Require Activation-Induced Cytidine Deaminase (AID), a Potential RNA Editing Enzyme , 2000, Cell.

[21]  T. Kita,et al.  Altered Th1/Th2 commitment in human CD4+ T cells with ageing , 2000, Clinical and experimental immunology.

[22]  C. Murre,et al.  Helix-Loop-Helix Proteins: Regulators of Transcription in Eucaryotic Organisms , 2000, Molecular and Cellular Biology.

[23]  C. Murre,et al.  E2A activity is induced during B‐cell activation to promote immunoglobulin class switch recombination , 1999, The EMBO journal.

[24]  R. Grosschedl,et al.  Coordinate regulation of B cell differentiation by the transcription factors EBF and E2A. , 1999, Immunity.

[25]  K. Hörmann,et al.  Age‐dependent altered proportions in subpopulations of tonsillar lymphocytes , 1999, Clinical and experimental immunology.

[26]  G. Kelsoe,et al.  Immunosenescence and germinal center reaction , 1997, Immunological reviews.

[27]  Haifeng Song,et al.  Age‐related changes in antibody repertoire: contribution from T cells , 1997, Immunological reviews.

[28]  N. Klinman,et al.  The B‐cell biology of aging , 1997, Immunological reviews.

[29]  M. Lieber,et al.  Interaction of DNA‐dependent protein kinase with DNA and with Ku: biochemical and atomic‐force microscopy studies , 1997, The EMBO journal.

[30]  M. Sigvardsson,et al.  EBF and E47 collaborate to induce expression of the endogenous immunoglobulin surrogate light chain genes. , 1997, Immunity.

[31]  X. Yang,et al.  Repertoire diversity of antibody response to bacterial antigens in aged mice. IV. Study of VH and VL gene utilization in splenic antibody foci by in situ hybridization. , 1994, Journal of immunology.

[32]  C. Vierra,et al.  E2A expression, nuclear localization, and in vivo formation of DNA- and non-DNA-binding species during B-cell development , 1993, Molecular and cellular biology.

[33]  D. Ehleiter,et al.  Effect of age on the expressed B cell repertoire: role of B cell subsets. , 1993, International immunology.

[34]  X. Yang,et al.  Repertoire diversity of antibody response to bacterial antigens in aged mice. III. Phosphorylcholine antibody from young and aged mice differ in structure and protective activity against infection with Streptococcus pneumoniae. , 1993, Journal of immunology.

[35]  M. Groudine,et al.  Helix-loop-helix transcription factors E12 and E47 are not essential for skeletal or cardiac myogenesis, erythropoiesis, chondrogenesis, or neurogenesis. , 1992, Proceedings of the National Academy of Sciences of the United States of America.

[36]  James W. Williams,et al.  Human B cel proliferative responses during aging. Reduced RNA synthesis and DNA replication after signal transduction by surface immunoglobulins compared to B cell antigenic determinants CD20 and CD40 , 1991, Mechanisms of Ageing and Development.

[37]  D. Schulze,et al.  Repertoire diversity of antibody response to bacterial antigens in aged mice. II. Phosphorylcholine-antibody in young and aged mice differ in both VH/VL gene repertoire and in specificity. , 1991, Journal of immunology.

[38]  D. Baltimore,et al.  Helix-loop-helix transcription factor E47 activates germ-line immunoglobulin heavy-chain gene transcription and rearrangement in a pre-T-cell line. , 1991, Genes & development.

[39]  H. Sakano,et al.  Immunoglobulin switch circular DNA in the mouse infected with Nippostrongylus brasiliensis: evidence for successive class switching from mu to epsilon via gamma 1. , 1990, Proceedings of the National Academy of Sciences of the United States of America.

[40]  K. Marcu,et al.  Altered VH gene segment utilization in the response to phosphorylcholine by aged mice. , 1989, Journal of immunology.

[41]  W. Paul,et al.  IL-4 induces co-expression of intrinsic membrane IgG1 and IgE by murine B cells stimulated with lipopolysaccharide. , 1988, Journal of immunology.

[42]  H. Mitsuya,et al.  Age-related decline in the in vitro and in vivo syntheses of anti-tetanus toxoid antibody in humans. , 1980, Journal of immunology.

[43]  R. Callard,et al.  Immune function in aged mice. I. T-cell responsiveness using phytohaemagglutinin as a functional probe. , 1977, Cellular immunology.

[44]  J. Innes,et al.  Immunological studies of aging. II. Loss of IgG and high avidity plaque- forming cells and increased suppressor cell activity in aging mice , 1976, The Journal of experimental medicine.

[45]  Y. Yokota,et al.  Essential role of Id2 in negative regulation of IgE class switching , 2003, Nature Immunology.

[46]  T. Honjo,et al.  Molecular mechanism of class switch recombination: linkage with somatic hypermutation. , 2002, Annual review of immunology.

[47]  C. Murre,et al.  E protein function in lymphocyte development. , 2002, Annual review of immunology.