Yoga for the sinoatrial node: sarcoplasmic reticulum calcium release confers flexibility.

[1]  E. Marder,et al.  Failure of averaging in the construction of a conductance-based neuron model. , 2002, Journal of neurophysiology.

[2]  E. Marder,et al.  Similar network activity from disparate circuit parameters , 2004, Nature Neuroscience.

[3]  I. Hisatome,et al.  Roles of sarcoplasmic reticulum Ca2+ cycling and Na+/Ca2+ exchanger in sinoatrial node pacemaking: insights from bifurcation analysis of mathematical models. , 2012, American journal of physiology. Heart and circulatory physiology.

[4]  E. Sobie Parameter sensitivity analysis in electrophysiological models using multivariable regression. , 2009, Biophysical journal.

[5]  Henggui Zhang,et al.  A mathematical model of action potentials of mouse sinoatrial node cells with molecular bases , 2011, American journal of physiology. Heart and circulatory physiology.

[6]  Blanca Rodríguez,et al.  Impact of ionic current variability on human ventricular cellular electrophysiology. , 2009, American journal of physiology. Heart and circulatory physiology.

[7]  Ulf G. Indahl,et al.  Multi-way metamodelling facilitates insight into the complex input-output maps of nonlinear dynamic models , 2012, BMC Systems Biology.

[8]  E. Lakatta,et al.  Numerical models based on a minimal set of sarcolemmal electrogenic proteins and an intracellular Ca(2+) clock generate robust, flexible, and energy-efficient cardiac pacemaking. , 2013, Journal of molecular and cellular cardiology.

[9]  E. Marder,et al.  Multiple models to capture the variability in biological neurons and networks , 2011, Nature Neuroscience.

[10]  Amrita X. Sarkar,et al.  Exploiting mathematical models to illuminate electrophysiological variability between individuals , 2012, The Journal of physiology.

[11]  Astrid A. Prinz,et al.  Conductance Ratios and Cellular Identity , 2010, PLoS Comput. Biol..

[12]  H. Mistry,et al.  An in silico canine cardiac midmyocardial action potential duration model as a tool for early drug safety assessment. , 2012, American journal of physiology. Heart and circulatory physiology.

[13]  H. Brown,et al.  How does adrenaline accelerate the heart? , 1979, Nature.

[14]  E. Lakatta A paradigm shift for the heart's pacemaker. , 2010, Heart rhythm.

[15]  H Zhang,et al.  Mathematical models of action potentials in the periphery and center of the rabbit sinoatrial node. , 2000, American journal of physiology. Heart and circulatory physiology.

[16]  D. DiFrancesco,et al.  The Pacemaker Current: From Basics to the Clinics , 2007, Journal of cardiovascular electrophysiology.

[17]  Prashanthan Sanders,et al.  Epistatic effects of potassium channel variation on cardiac repolarization and atrial fibrillation risk. , 2012, Journal of the American College of Cardiology.

[18]  Dario DiFrancesco,et al.  Cycling in the Mechanism of Pacemaking Cardiac Pacemaking : Historical Overview and Future Directions , 2010 .

[19]  Eric A. Sobie,et al.  Regression Analysis for Constraining Free Parameters in Electrophysiological Models of Cardiac Cells , 2009, PLoS Comput. Biol..

[20]  R. Bertram,et al.  Investigating Heterogeneity of Intracellular Calcium Dynamics in Anterior Pituitary Lactotrophs Using a Combined Modelling/Experimental Approach , 2010, Journal of neuroendocrinology.

[21]  Blanca Rodríguez,et al.  Systematic characterization of the ionic basis of rabbit cellular electrophysiology using two ventricular models. , 2011, Progress in biophysics and molecular biology.

[22]  E. Marder,et al.  How Multiple Conductances Determine Electrophysiological Properties in a Multicompartment Model , 2009, The Journal of Neuroscience.

[23]  Eric A Sobie,et al.  Excitation–contraction coupling gain in ventricular myocytes: insights from a parsimonious model , 2009, The Journal of physiology.

[24]  Annalisa Bucchi,et al.  The cardiac pacemaker current. , 2010, Journal of molecular and cellular cardiology.

[25]  Edward G Lakatta,et al.  Synergism of coupled subsarcolemmal Ca2+ clocks and sarcolemmal voltage clocks confers robust and flexible pacemaker function in a novel pacemaker cell model. , 2009, American journal of physiology. Heart and circulatory physiology.

[26]  Dario DiFrancesco,et al.  The funny current has a major pacemaking role in the sinus node. , 2012, Heart rhythm.

[27]  Yasutaka Kurata,et al.  Dynamical description of sinoatrial node pacemaking: improved mathematical model for primary pacemaker cell. , 2002, American journal of physiology. Heart and circulatory physiology.

[28]  Eleazar Eskin,et al.  "Good enough solutions" and the genetics of complex diseases. , 2012, Circulation research.

[29]  Gary R. Mirams,et al.  mRNA Expression Levels in Failing Human Hearts Predict Cellular Electrophysiological Remodeling: A Population-Based Simulation Study , 2013, PloS one.

[30]  Dario DiFrancesco,et al.  What keeps us ticking: a funny current, a calcium clock, or both? , 2009, Journal of molecular and cellular cardiology.

[31]  Colleen E. Clancy,et al.  Determinants of Heterogeneity, Excitation and Conduction in the Sinoatrial Node: A Model Study , 2010, PLoS Comput. Biol..

[32]  Stefano Severi,et al.  An updated computational model of rabbit sinoatrial action potential to investigate the mechanisms of heart rate modulation , 2012, The Journal of physiology.

[33]  Edward G Lakatta,et al.  The funny current in the context of the coupled-clock pacemaker cell system. , 2012, Heart rhythm.

[34]  D. Noble,et al.  A model of sino-atrial node electrical activity based on a modification of the DiFrancesco-Noble (1984) equations , 1984, Proceedings of the Royal Society of London. Series B. Biological Sciences.

[35]  Eric A Sobie,et al.  Quantification of repolarization reserve to understand interpatient variability in the response to proarrhythmic drugs: a computational analysis. , 2011, Heart rhythm.

[36]  Edward G Lakatta,et al.  A coupled SYSTEM of intracellular Ca2+ clocks and surface membrane voltage clocks controls the timekeeping mechanism of the heart's pacemaker. , 2010, Circulation research.

[37]  A. Noma,et al.  Reconstruction of sino-atrial node pacemaker potential based on the voltage clamp experiments. , 1980, The Japanese journal of physiology.