The increased prevalence of allergy and the hygiene hypothesis: missing immune deviation, reduced immune suppression, or both?
暂无分享,去创建一个
[1] E. Gelfand,et al. Nebulized but not parenteral IFN-gamma decreases IgE production and normalizes airways function in a murine model of allergen sensitization. , 1994, Journal of immunology.
[2] S. Maleki,et al. Characterization of lymphocyte responses to peanuts in normal children, peanut-allergic children, and allergic children who acquired tolerance to peanuts. , 2003, The Journal of clinical investigation.
[3] E. Gelfand,et al. Nebulized IFN-gamma inhibits the development of secondary allergic responses in mice. , 1996, Journal of immunology.
[4] R. Pauwels,et al. Is Th1 the solution for Th2 in asthma? , 2002, Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology.
[5] B. Toelle,et al. The effect of neonatal BCG vaccination on atopy and asthma at age 7 to 14 years: an historical cohort study in a community with a very low prevalence of tuberculosis infection and a high prevalence of atopic disease. , 2003, The Journal of allergy and clinical immunology.
[6] F. Annunziato,et al. Polyinosinic acid: polycytidylic acid promotes T helper type 1‐specific immune responses by stimulating macrophage production of interferon‐α and interleukin‐12 , 1995, European journal of immunology.
[7] P. Barnes,et al. Increased interleukin-4 and decreased interferon-gamma in exhaled breath condensate of children with asthma. , 2002, American journal of respiratory and critical care medicine.
[8] T. Platts-Mills,et al. Sensitisation, asthma, and a modified Th2 response in children exposed to cat allergen: a population-based cross-sectional study , 2001, The Lancet.
[9] The Inverse Association Between Tuberculin Responses and Atopic Disorder , 1997, Science.
[10] M. Wills-Karp,et al. Mucosal IFN-gamma gene transfer inhibits pulmonary allergic responses in mice. , 1996, Journal of immunology.
[11] J. Fujimoto,et al. Interleukin 18 Acts on Memory T Helper Cells Type 1 to Induce Airway Inflammation and Hyperresponsiveness in a Naive Host Mouse , 2004, The Journal of experimental medicine.
[12] D. P. Strachan,et al. Hay fever, hygiene, and household size. , 1989, BMJ.
[13] S. Weiland,et al. T(H)1/T(H)2 immune response profiles differ between atopic children in eastern and western Germany. , 2002, The Journal of allergy and clinical immunology.
[14] Z. Jaffar,et al. CD4+CD25+ T Cells Regulate Airway Eosinophilic Inflammation by Modulating the Th2 Cell Phenotype1 , 2004, The Journal of Immunology.
[15] Sergio Romagnani,et al. Immunologic influences on allergy and the TH1/TH2 balance. , 2004, The Journal of allergy and clinical immunology.
[16] D. Weissman,et al. Cutting Edge: Innate Immune System Discriminates between RNA Containing Bacterial versus Eukaryotic Structural Features That Prime for High-Level IL-12 Secretion by Dendritic Cells1 , 2004, The Journal of Immunology.
[17] G. Berry,et al. CD4(+) T helper cells engineered to produce latent TGF-beta1 reverse allergen-induced airway hyperreactivity and inflammation. , 2000, The Journal of clinical investigation.
[18] P. Holt,et al. Neonatal interleukin‐12 capacity is associated with variations in allergen‐specific immune responses in the neonatal and postnatal periods , 2003, Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology.
[19] A. Rudensky,et al. Foxp3 programs the development and function of CD4+CD25+ regulatory T cells , 2003, Nature Immunology.
[20] U. Wahn,et al. Endotoxins prevent murine IgE production, T(H)2 immune responses, and development of airway eosinophilia but not airway hyperreactivity. , 2002, The Journal of allergy and clinical immunology.
[21] J. Holloway,et al. Infection of Mice with Mycobacterium bovis–Bacillus Calmette-Guérin (BCG) Suppresses Allergen-induced Airway Eosinophilia , 1998, The Journal of experimental medicine.
[22] R. Townley,et al. The effect of BCG vaccine at birth on the development of atopy or allergic disease in young children. , 2004, Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology.
[23] L. Cosmi,et al. The novel synthetic immune response modifier R-848 (Resiquimod) shifts human allergen-specific CD4+ TH2 lymphocytes into IFN-gamma-producing cells. , 2003, The Journal of allergy and clinical immunology.
[24] Richard J. Johnson,et al. Hypothesis: dysregulation of immunologic balance resulting from hygiene and socioeconomic factors may influence the epidemiology and cause of glomerulonephritis worldwide. , 2003, American journal of kidney diseases : the official journal of the National Kidney Foundation.
[25] S. Szabo,et al. Transcriptional regulation of Th1/Th2 polarization. , 2000, Immunology today.
[26] D. Liggitt,et al. Viral-induced T helper type 1 responses enhance allergic disease by effects on lung dendritic cells , 2004, Nature Immunology.
[27] Michael R. Green,et al. Gene Expression , 1993, Progress in Gene Expression.
[28] F. Annunziato,et al. Phosphorothioate oligodeoxynucleotides promote the in vitro development of human allergen-specific CD4+ T cells into Th1 effectors. , 1999, Journal of immunology.
[29] G. Berry,et al. CD4 T-helper cells engineered to produce IL-10 prevent allergen-induced airway hyperreactivity and inflammation. , 2002, The Journal of allergy and clinical immunology.
[30] S. Romagnani. The role of lymphocytes in allergic disease. , 2000, The Journal of allergy and clinical immunology.
[31] L. A. Rosenthal,et al. LIPOPOLYSACCHARIDE-ENHANCED, TOLL-LIKE RECEPTOR 4-DEPENDENT, T HELPER CELL TYPE 2 RESPONSES TO INHALED ANTIGEN , 2004, Pediatrics.
[32] H. Jansen,et al. Functional subsets of allergen-reactive human CD4+ T cells. , 1991, Immunology today.
[33] R. Martin,et al. The effects of inhaled interferon gamma in normal human airways. , 1993, The American review of respiratory disease.
[34] S. Szabo,et al. Development of Spontaneous Airway Changes Consistent with Human Asthma in Mice Lacking T-bet , 2002, Science.
[35] M. Roncarolo,et al. Type 1 T regulatory cells , 2001, Immunological reviews.
[36] S. Durham,et al. Increases in IL-12 messenger RNA+ cells accompany inhibition of allergen-induced late skin responses after successful grass pollen immunotherapy. , 1997, The Journal of allergy and clinical immunology.
[37] R. Coffman,et al. Experimental Leishmania major infection in mice: role of IL‐10 , 1999, Parasite immunology.
[38] P. Openshaw,et al. Age at First Viral Infection Determines the Pattern of T Cell–mediated Disease during Reinfection in Adulthood , 2002, The Journal of experimental medicine.
[39] G. Berry,et al. IL-18 Gene Transfer by Adenovirus Prevents the Development of and Reverses Established Allergen-Induced Airway Hyperreactivity1 , 2001, The Journal of Immunology.
[40] C. Karp,et al. The germless theory of allergic disease: revisiting the hygiene hypothesis , 2001, Nature Reviews Immunology.
[41] M. de Carli,et al. Reciprocal regulatory effects of IFN-gamma and IL-4 on the in vitro development of human Th1 and Th2 clones. , 1992, Journal of immunology.
[42] F. Farrokhyar,et al. A critical review of epidemiological studies in inflammatory bowel disease. , 2001 .
[43] B. Pulendran,et al. Cutting Edge: Different Toll-Like Receptor Agonists Instruct Dendritic Cells to Induce Distinct Th Responses via Differential Modulation of Extracellular Signal-Regulated Kinase-Mitogen-Activated Protein Kinase and c-Fos 1 , 2003, The Journal of Immunology.
[44] S. Romagnani. Lymphokine production by human T cells in disease states. , 1994, Annual review of immunology.
[45] Kotaro Suzuki,et al. Role of CD4(+) CD25(+) regulatory T cells in T helper 2 cell-mediated allergic inflammation in the airways. , 2001, American journal of respiratory and critical care medicine.
[46] J. Bijlsma,et al. Th2 mediated regulation in RA and the spondyloarthropathies , 2002, Annals of the rheumatic diseases.
[47] S. Szabo,et al. Modulation of airway inflammation by passive transfer of allergen-specific Th1 and Th2 cells in a mouse model of asthma. , 1999, Journal of immunology.
[48] Lorian,et al. ENVIRONMENTAL EXPOSURE TO ENDOTOXIN AND ITS RELATION TO ASTHMA IN SCHOOL-AGE CHILDREN , 2022 .
[49] F. Farrokhyar,et al. A critical review of epidemiological studies in inflammatory bowel disease. , 2001, Scandinavian journal of gastroenterology.
[50] G. Trinchieri,et al. Natural killer cell stimulatory factor (interleukin 12 [IL-12]) induces T helper type 1 (Th1)-specific immune responses and inhibits the development of IL-4-producing Th cells , 1993, The Journal of experimental medicine.
[51] E. Gelfand,et al. Systemic and local interferon gamma gene delivery to the lungs for treatment of allergen-induced airway hyperresponsiveness in mice. , 1999, Human gene therapy.
[52] G. Pershagen,et al. Atopy in children of families with an anthroposophic lifestyle , 1999, The Lancet.
[53] E. Schmitt,et al. Influenza A Virus Infection Inhibits the Efficient Recruitment of Th2 Cells into the Airways and the Development of Airway Eosinophilia1 , 2003, The Journal of Immunology.
[54] E. Reinke,et al. Immunoregulation of CNS autoimmunity by helminth and mycobacterial infections. , 2002, Immunology letters.
[55] N. Lynch,et al. Allergic reactivity and socio‐economic level in a tropical environment , 1987, Clinical allergy.
[56] P. Lipsky,et al. Generation and Regulation of Human Th1-Biased Immune Responses In Vivo: A Critical Role for IL-4 and IL-10 1 , 2004, The Journal of Immunology.
[57] H. van Loveren,et al. Mycobacterium vaccae administration during allergen sensitization or challenge suppresses asthmatic features , 2003, Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology.
[58] Richard J Martin,et al. The effects of nebulized recombinant interferon-γ in asthmatic airways , 1995 .
[59] E. Shevach,et al. CD4+CD25+ T cells inhibit both the induction and effector function of autoreactive T cells and represent a unique lineage of immunoregulatory cells. , 1998, Journal of immunology.
[60] M. Kaplan,et al. Impaired IL-12 responses and enhanced development of Th2 cells in Stat4-deficient mice , 1996, Nature.
[61] M. Byrne,et al. CD4(+)CD25(+) immunoregulatory T cells: gene expression analysis reveals a functional role for the glucocorticoid-induced TNF receptor. , 2002, Immunity.
[62] H. Wichmann,et al. House dust endotoxin and allergic sensitization in children. , 2002, American journal of respiratory and critical care medicine.
[63] M. Netea,et al. Toll-Like Receptor 2 Suppresses Immunity against Candida albicans through Induction of IL-10 and Regulatory T Cells , 2004, The Journal of Immunology.
[64] Laurie H Glimcher,et al. A Novel Transcription Factor, T-bet, Directs Th1 Lineage Commitment , 2000, Cell.
[65] J. Coste,et al. Reduced incidence and prevalence of atopy in rheumatoid arthritis. Results of a case-control study. , 2000, Rheumatology.
[66] D. Luscombe,et al. Asthma and multiple sclerosis: an inverse association in a case-control general practice population. , 2002, QJM : monthly journal of the Association of Physicians.
[67] P. Sly,et al. The role of allergy in the development of asthma , 1999, Nature.
[68] S. Romagnani,et al. Regulation of the development of type 2 T-helper cells in allergy. , 1994, Current opinion in immunology.
[69] L. Cosmi,et al. Reversal of human allergen-specific CRTH2+ T(H)2 cells by IL-12 or the PS-DSP30 oligodeoxynucleotide. , 2001, The Journal of allergy and clinical immunology.
[70] D. Umetsu,et al. Reduced prevalence of allergic disease in patients with multiple sclerosis is associated with enhanced IL-12 production. , 1998, The Journal of allergy and clinical immunology.
[71] F. Sennhauser,et al. Expression of CD14 and Toll-like receptor 2 in farmers' and nonfarmers' children , 2002, The Lancet.
[72] Kim Bottomly,et al. Lipopolysaccharide-enhanced, Toll-like Receptor 4–dependent T Helper Cell Type 2 Responses to Inhaled Antigen , 2002, The Journal of experimental medicine.
[73] A. Mercenier,et al. Lactic acid bacteria inhibit TH2 cytokine production by mononuclear cells from allergic patients. , 2002, The Journal of allergy and clinical immunology.
[74] R. Geha,et al. IL-10 is critical for Th2 responses in a murine model of allergic dermatitis. , 2003, The Journal of clinical investigation.
[75] H. Ochs,et al. Immune dysregulation, polyendocrinopathy, enteropathy, and X-linked inheritance (IPEX), a syndrome of systemic autoimmunity caused by mutations of FOXP3, a critical regulator of T-cell homeostasis , 2003, Current opinion in rheumatology.
[76] Maria Yazdanbakhsh,et al. Allergy, parasites, and the hygiene hypothesis. , 2002, Science.
[77] M. Dallman,et al. Relation of CD4+CD25+ regulatory T-cell suppression of allergen-driven T-cell activation to atopic status and expression of allergic disease , 2004, The Lancet.
[78] E. Raz,et al. Cutting Edge: Activation of Toll-Like Receptor 2 Induces a Th2 Immune Response and Promotes Experimental Asthma1 , 2004, The Journal of Immunology.
[79] G. Berry,et al. Allergen-specific Th1 cells fail to counterbalance Th2 cell-induced airway hyperreactivity but cause severe airway inflammation. , 1999, The Journal of clinical investigation.
[80] P. Matricardi,et al. Parasites and the hygiene hypothesis , 2004, Clinical reviews in allergy & immunology.
[81] R. Pauwels,et al. Interleukin-12 inhibits antigen-induced airway hyperresponsiveness in mice. , 1996, American journal of respiratory and critical care medicine.
[82] Inverse Association between Tuberculin Responses and Atopic Disorders , 1999 .
[83] S. Bonini,et al. Exposure to foodborne and orofecal microbes versus airborne viruses in relation to atopy and allergic asthma: epidemiological study , 2000, BMJ : British Medical Journal.
[84] L. Steinman,et al. Regulation of disease susceptibility: decreased prevalence of IgE-mediated allergic disease in patients with multiple sclerosis. , 1996, The Journal of allergy and clinical immunology.
[85] S. Durham,et al. Grass Pollen Immunotherapy Induces Mucosal and Peripheral IL-10 Responses and Blocking IgG Activity1 , 2004, The Journal of Immunology.
[86] Joanne M. Smart,et al. Polyclonal and allergen-induced cytokine responses in adults with asthma: resolution of asthma is associated with normalization of IFN-gamma responses. , 2002, The Journal of allergy and clinical immunology.
[87] G. Wohlleben,et al. Application of heat killed Mycobacterium bovis-BCG into the lung inhibits the development of allergen-induced Th2 responses. , 2002, Vaccine.
[88] G. Rook,et al. Suppression of airway eosinophilia by killed Mycobacterium vaccae-induced allergen-specific regulatory T-cells , 2002, Nature Medicine.
[89] Kenneth M. Murphy,et al. Functional diversity of helper T lymphocytes , 1996, Nature.
[90] Marek Jutel,et al. IL‐10 and TGF‐β cooperate in the regulatory T cell response to mucosal allergens in normal immunity and specific immunotherapy , 2003, European journal of immunology.
[91] C. Akdis,et al. Interleukin‐10, T regulatory cells and specific allergy treatment , 2004, Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology.
[92] D. H. Zhang,et al. Gene expression of the GATA-3 transcription factor is increased in atopic asthma. , 1999, The Journal of allergy and clinical immunology.
[93] H. Weiner,et al. Induction and mechanism of action of transforming growth factor‐β‐secreting Th3 regulatory cells , 2001, Immunological reviews.
[94] F. Martinez. The coming-of-age of the hygiene hypothesis , 2001, Respiratory research.
[95] Jonathan M. Austyn,et al. Dendritic cells , 1998, Current opinion in hematology.
[96] A. Kay,et al. The role of T lymphocytes in the pathogenesis of asthma. , 2003, The Journal of allergy and clinical immunology.
[97] J. Walker,et al. Declining incidence of multiple sclerosis in the Orkney Islands , 1985, Neurology.
[98] L. Cosmi,et al. Th2 cells are less susceptible than Th1 cells to the suppressive activity of CD25+ regulatory thymocytes because of their responsiveness to different cytokines. , 2004, Blood.
[99] G. Rosati,et al. Multiple sclerosis epidemiology in Sardinia: evidence for a true increasing risk , 2001, Acta neurologica Scandinavica.
[100] J. Bach,et al. The effect of infections on susceptibility to autoimmune and allergic diseases. , 2002, The New England journal of medicine.
[101] P. Lipsky,et al. GATA-3 in Human T Cell Helper Type 2 Development , 2004, The Journal of experimental medicine.
[102] D. Klinman. Immunotherapeutic uses of CpG oligodeoxynucleotides , 2004, Nature Reviews Immunology.
[103] E. Raz,et al. Conjugation of immunostimulatory DNA to the short ragweed allergen amb a 1 enhances its immunogenicity and reduces its allergenicity. , 2000, The Journal of allergy and clinical immunology.
[104] M. de Carli,et al. IL-4 and IFN (alpha and gamma) exert opposite regulatory effects on the development of cytolytic potential by Th1 or Th2 human T cell clones. , 1992, Journal of immunology.
[105] M. Jordana,et al. Interleukin-10 gene transfer to the airway regulates allergic mucosal sensitization in mice. , 1999, American journal of respiratory cell and molecular biology.
[106] R. Coffman,et al. T Regulatory Cells 1 Inhibit a Th2-Specific Response In Vivo1 , 2000, The Journal of Immunology.
[107] M. Herold,et al. Dendritic cells contribute to the development of atopy by an insufficiency in IL-12 production. , 2002, The Journal of allergy and clinical immunology.
[108] R. Lauener,et al. Expression of CD 14 and Toll-like receptor 2 In farmers ’ and non-farmers ’ childien , 2003 .
[109] M. Noris,et al. Natural versus adaptive regulatory T cells. , 2005, Contributions to nephrology.
[110] A. Knulst,et al. CD4 CD25 regulatory T cells are not functionally impaired in adult patients with IgE-mediated cow's milk allergy. , 2002, The Journal of allergy and clinical immunology.
[111] M. Kopf,et al. Bystander suppression of allergic airway inflammation by lung resident memory CD8+ T cells. , 2004, Proceedings of the National Academy of Sciences of the United States of America.
[112] V. Gangur,et al. Human Ip-10 Selectively Promotes Dominance of Polyclonally Activated and Environmental Antigen- Driven Ifn-g over Il-4 Responses Human Ip-10 Selectively Promotes Dominance of Polyclonally Activated and Environmental Antigen- Driven Ifn-g over Il-4 Responses. Faseb , 2022 .
[113] A. Paller,et al. Atopic dermatitis and the atopic march. , 2003, The Journal of allergy and clinical immunology.
[114] Sotgiu Stefano,et al. ReviewDoes the “Hygiene Hypothesis” Provide an Explanation for the High Prevalence of Multiple Sclerosis in Sardinia? , 2003 .