P4-009: Transitioning forward to CDR 0.5 and 1+ versus backward from CDR 0.5 to 0: Are the risk factors the same? The Kame Project

Conclusions: Our results suggest that FHx of AD has a stronger association with microstructural brain differences, than 4. Presence of 4 alone was not associated with measurable difference, though presence of FHx and 4 resulted in the greatest difference in FA. These results support the conclusion that a greater emphasis be placed on elucidating the contribution of FHx to early brain changes in people at risk for AD. Additionally, our results provide evidence that DTI may be useful for detecting or tracking AD related brain changes, prior to disease onset.