论文信息 - DETERMINATION OF HUMAN AGE BASED ON THE ANALYSIS OF THE STATUS OF CpG SITES METHYLATION IN SPERM DNA

DETERMINATION OF HUMAN AGE BASED ON THE ANALYSIS OF THE STATUS OF CpG SITES METHYLATION IN SPERM DNA

Based on bioinformatics and statistical analysis of GEO-projects on the determination of the genome-wide profile of human DNA methylation, a list of CpG dinucleotides with high predictive potential was formed to design models allowing to predict human age by sperm samples. The methylation level was determined for 467 males from the Republic of Belarus. The correlation coefficients R were calculated, and mathematical models for determining the age of an individual were constructed. The average value of the accuracy of age prediction by sperm samples using 5 CpG-dinucleotides was 3 years. The results obtained will be used as a basis for the development of calculators for predicting the age of an individual based on the traces of biological character for forensic experts.

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