A fingerprint of the epileptogenic zone in human epilepsies

Identifying an electrical biomarker of epileptogenicity would facilitate epilepsy surgery. Using time-frequency analysis during the pre-ictal-to-ictal transition, Grinenko et al. identify a fingerprint of the epileptogenic zone, which they validate through machine learning. The time-frequency pattern is consistent with a pathophysiological role of fast inhibitory interneurons in seizure onset.

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