Novel image analysis method for in situ monitoring the particle size distribution of batch crystallization processes

This article presents a new in situ method to monitor the particle size distribution (PSD) during batch solution crystallization processes. Using a new in situ imaging probe, the "EZProbe sensor," real time acquisition of 2-D images of particles during the batch process is now possible. To analyze these images, a novel image analysis method is carried out. First, segmentation and restoration algorithms are performed to identify the particles and thereafter geometrical particle measurements are achieved to obtained the PSD of the batch crystallization process over time. Satisfactory measurements are obtained provided that the overall solid concentration does not exceed a threshold above which too many overlapping crystals make discrimination between particles impossible.

[1]  Luc Vincent,et al.  Morphological grayscale reconstruction in image analysis: applications and efficient algorithms , 1993, IEEE Trans. Image Process..

[2]  D. A. Fish,et al.  Blind deconvolution by means of the Richardson-Lucy algorithm. , 1995 .

[3]  Ying Zhou,et al.  Critical evaluation of image processing approaches for real-time crystal size measurements , 2009, Comput. Chem. Eng..

[4]  Deepa Kundur,et al.  Blind image deconvolution revisited , 1996 .

[5]  Kevin J. Roberts,et al.  Sensitivity of particle sizing by ultrasonic attenuation spectroscopy to material properties , 2003 .

[6]  Dilum D. Dunuwila,et al.  An investigation of the applicability of attenuated total reflection infrared spectroscopy for measurement of solubility and supersaturation of aqueous citric acid solutions , 1994 .

[7]  Kevin J. Roberts,et al.  Multi-scale segmentation image analysis for the in-process monitoring of particle shape with batch crystallisers , 2005 .

[8]  Raveendran Paramesran,et al.  Measure of image sharpness using eigenvalues , 2007, Inf. Sci..

[9]  James B. Rawlings,et al.  An algorithm for analyzing noisy, in situ images of high-aspect-ratio crystals to monitor particle size distribution , 2006 .

[10]  F. Puel,et al.  On-line ATR FTIR measurement of supersaturation during solution crystallization processes. Calibration and applications on three solute/solvent systems , 2001 .

[11]  P. Yap,et al.  Image focus measure based on Chebyshev moments , 2004 .

[12]  Rainer H Müller,et al.  Size analysis of submicron particles by laser diffractometry--90% of the published measurements are false. , 2008, International journal of pharmaceutics.

[13]  Tae-Sun Choi,et al.  Focusing techniques , 1992, Other Conferences.

[14]  Serge Beucher,et al.  THE WATERSHED TRANSFORMATION APPLIED TO IMAGE SEGMENTATION , 2009 .

[15]  W. Marsden.  I and J , 2012 .

[16]  Pierre Soille,et al.  Morphological Image Analysis: Principles and Applications , 2003 .

[17]  Marco Mazzotti,et al.  Restoration of PSD from Chord Length Distribution Data using the Method of Projections onto Convex Sets , 2005 .

[18]  R. Braatz,et al.  Measurement of particle size distribution in suspension polymerization using in situ laser backscattering , 2003 .

[19]  Jan Flusser,et al.  A new wavelet-based measure of image focus , 2002, Pattern Recognit. Lett..