Cerebral normoxia in the rhesus monkey during isofluraneor propofol‐induced hypotension and hypocapnia, despite disparate blood‐flow patterns

Background: Due to a few reports of cerebral dysfunction in connection with isoflurane‐induced hypotension and concomitant hypocapnia, positron emission tomography (PET) was used to measure cerebral oxygenation and blood flow during similar conditions with isoflurane or propofol.

[1]  C. Bohm,et al.  Automated blood sampling systems for positron emission tomography , 1988 .

[2]  K Wienhard,et al.  Use of PET Methods for Measurement of Cerebral Energy Metabolism and Hemodynamics in Cerebrovascular Disease , 1989, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[3]  L. Gjessing,et al.  SOME MAIN TRENDS IN THE CLINICAL ASPECTS OF PERIODIC CATATONIA , 1961, Acta psychiatrica Scandinavica.

[4]  J. van Egmond,et al.  Propofol ('Diprivan') emulsion for total intravenous anaesthesia. , 1985, Postgraduate medical journal.

[5]  A. Vandesteene,et al.  Effect of propofol on cerebral blood flow and metabolism in man , 1988, Anaesthesia.

[6]  M. Raichle,et al.  Brain blood flow measured with intravenous H2(15)O. I. Theory and error analysis. , 1983, Journal of nuclear medicine : official publication, Society of Nuclear Medicine.

[7]  M. White,et al.  EVALUATION OF A COMPUTERISED PROPOFOL INFUSION SYSTEM , 1989 .

[8]  C. Cordiner,et al.  A COMPARISON OF MENTAL FUNCTION IN RELATION TO HYPOTENSIVE AND NORMOTENSIVE ANAESTHESIA IN THE ELDERLY , 1971 .

[9]  P. Talke,et al.  Desflurane and Isoflurane Increase Lumbar Cerebrospinal Fluid Pressure in Normocapnic Patients Undergoing Transsphenoidal Hypophysectomy , 1996, Anesthesiology.

[10]  H I Glass,et al.  Effect of alterations in the arterial carbon dioxide tension on the blood flow through the cerebral cortex at normal and low arterial blood pressures. , 1965 .

[11]  W. Huk,et al.  Cerebral complications following induced hypotension. , 1986, European journal of anaesthesiology.

[12]  B. Matta,et al.  Direct Cerebrovasodilatory Effects of Halothane, Isoflurane, and Desflurane during Propofol‐induced Isoelectric Electroencephalogram in Humans , 1995, Anesthesiology.

[13]  David I. Graham,et al.  Cardiovascular and Cerebrovascular Effects of Isoflurane‐Induced Hypotension in the Baboon , 1986, Anesthesia and analgesia.

[14]  C. Cordiner,et al.  A comparison of mental function in relation to hypotensive and normotensive anaesthesia in the elderly. , 1972, British journal of anaesthesia.

[15]  E. Ryding,et al.  Distribution of Cerebral Blood Flow during Anesthesia with Isoflurane or Halothane in Humans , 1995, Anesthesiology.

[16]  J. Compton,et al.  ASSESSMENT OF CEREBRAL EFFECTS OF DELIBERATE HYPOTENSION BY PSYCHOLOGICAL MEASUREMENTS. , 1964, Lancet.

[17]  M. Mintun,et al.  Brain oxygen utilization measured with O-15 radiotracers and positron emission tomography. , 1984, Journal of nuclear medicine : official publication, Society of Nuclear Medicine.

[18]  D. Pm,et al.  Propofol ('Diprivan') emulsion for total intravenous anaesthesia. , 1985 .

[19]  M Diksic,et al.  Measurement of cerebral blood flow and volume with positron emission tomography during isoflurane administration in the hypocapnic baboon. , 1990, Anesthesiology.

[20]  J. Sibert,et al.  Hypernatraemic dehydration and necrotizing enterocolitis. , 1985, Postgraduate medical journal.

[21]  M. Raichle,et al.  What is the Correct Value for the Brain-Blood Partition Coefficient for Water? , 1985, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[22]  P. Wouters,et al.  Vital Organ Blood Flow During Deliberate Hypotension in Dogs , 1993, Anesthesia and analgesia.

[23]  Karl J. Friston,et al.  A multivariate analysis of PET activation studies , 1996, Human brain mapping.

[24]  J. Adams,et al.  The effects of systemic hypotension upon the human brain. Clinical and neuropathological observations in 11 cases. , 1966, Brain : a journal of neurology.

[25]  R. Frackowiak,et al.  Quantitative Measurement of Regional Cerebral Blood Flow and Oxygen Metabolism in Man Using 15O and Positron Emission Tomography: Theory, Procedure, and Normal Values , 1980, Journal of computer assisted tomography.

[26]  M. Raichle,et al.  Cerebral Blood Volume Measured with Inhaled C15O and Positron Emission Tomography , 1987, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[27]  A. Artru,et al.  Electroencephalogram, cerebral metabolic, and vascular responses to propofol anesthesia in dogs. , 1992, Journal of neurosurgical anesthesiology.

[28]  L. Kebbon,et al.  Changes in mental functions after induced hypotension. , 1962, Acta Psychiatrica Scandinavica Supplementum.

[29]  G. Antoni,et al.  Brain kinetics of (R)- and (S)-[N-methyl-11C]ketamine in the rhesus monkey studied by positron emission tomography (PET). , 1994, Nuclear medicine and biology.

[30]  E. Rota Kops,et al.  Performance characteristics of an eight-ring whole body PET scanner. , 1990, Journal of computer assisted tomography.

[31]  G T Lewis,et al.  Induction and maintenance of propofol anaesthesia , 1988, Anaesthesia.

[32]  A A Lammertsma,et al.  Correction for the Presence of Intravascular Oxygen-15 in the Steady-State Technique for Measuring Regional Oxygen Extraction Ratio in the Brain: 1. Description of the Method , 1983, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[33]  G. Ronquist,et al.  Occurrence of adenylate kinase in cerebrospinal fluid after isoflurane anaesthesia and orthognathic surgery. , 1996, Upsala journal of medical sciences.

[34]  K. Bergström,et al.  MULTIPLANAR SPINAL ANATOMY: COMPARISON OF COMPUTED TOMOGRAPHY AND CRYOMICROTOMY IN POSTMORTEM SPECIMENS , 1983 .

[35]  C. Bohm,et al.  Correction for Scattered Radiation in a Ring Detector Positron Camera by Integral Transformation of the Projections , 1983, Journal of computer assisted tomography.

[36]  G. Ronquist,et al.  Adverse effects on the brain in connection with isoflurane‐induced hypotensive anaesthesia , 1989 .

[37]  R J Wise,et al.  Correction for the Presence of Intravascular Oxygen-15 in the Steady-State Technique for Measuring Regional Oxygen Extraction Ratio in the Brain: 2. Results in Normal Subjects and Brain Tumour and Stroke Patients , 1983, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[38]  W. Hoffman,et al.  Cerebral autoregulation in awake versus isoflurane-anesthetized rats. , 1991, Anesthesia and analgesia.

[39]  N. Morton,et al.  Pharmacokinetic model driven infusion of propofol in children. , 1991, British journal of anaesthesia.

[40]  P. Prior,et al.  The pathogenesis of ischaemic neuronal damage along the cerebral arterial boundary zones in Papio anubis. , 1980, Brain : a journal of neurology.

[41]  E. Meyer Simultaneous correction for tracer arrival delay and dispersion in CBF measurements by the H215O autoradiographic method and dynamic PET. , 1989, Journal of nuclear medicine : official publication, Society of Nuclear Medicine.