Biomedical applications of nanostructured porous silicon: a review

Current fabrication and characterization techniques allow the development of nanostructured systems with controlled size, shape and composition. Additionally, modifications can be made to these nanosystems to better suit their integration with biological systems, leading to such interesting properties as enhanced aqueous solubility, biocompatibility or bio-recognition. The particular morphology and overall properties of nanostructured porous silicon allow the use of this material in the fields of drug delivery, eye diseases, tumor imaging, and tissue engineering.

[1]  V. Litovchenko,et al.  Porous silicon microstructure and composition characterization depending on the formation conditions , 2006 .

[2]  Volker Lehmann,et al.  Electrochemistry of Silicon: Instrumentation, Science, Materials and Applications , 2002 .

[3]  R. P. Thompson,et al.  Silicic acid: its gastrointestinal uptake and urinary excretion in man and effects on aluminium excretion. , 1999, Journal of inorganic biochemistry.

[4]  L. Canham,et al.  Derivatized Mesoporous Silicon with Dramatically Improved Stability in Simulated Human Blood Plasma , 1999 .

[5]  J. Buriak,et al.  Chemical and Biological Applications of Porous Silicon Technology , 2000 .

[6]  Rui L Reis,et al.  Bone tissue engineering: state of the art and future trends. , 2004, Macromolecular bioscience.

[7]  W. Freeman,et al.  Intravitreal properties of porous silicon photonic crystals: a potential self-reporting intraocular drug-delivery vehicle , 2008, British Journal of Ophthalmology.

[8]  R. Muller,et al.  Chemical Surface Modification of Porous Silicon , 1993 .

[9]  Vicente Torres-Costa,et al.  Optical Biosensors Based on Semiconductor Nanostructures , 2009, Sensors.

[10]  David J. Wallis,et al.  Dissolution of different forms of partially porous silicon wafers under simulated physiological conditions , 2003 .

[11]  Rolf E. Hummel,et al.  Novel technique for preparing porous silicon , 1992 .

[12]  V. Lehto,et al.  Mesoporous silicon microparticles for oral drug delivery: loading and release of five model drugs. , 2005, Journal of controlled release : official journal of the Controlled Release Society.

[13]  L. Canham.  Bioactive silicon structure fabrication through nanoetching techniques , 1995 .

[14]  D. R. Turner.  Electropolishing Silicon in Hydrofluoric Acid Solutions , 1958 .

[15]  Trevor M. Benson,et al.  Porous silicon multilayer optical waveguides , 1996 .

[16]  R. Martín-Palma,et al.  Application of nanostructured porous silicon in the field of optics. A review , 2010 .

[17]  J. M. Martínez-Duart,et al.  Direct determination of grain sizes, lattice parameters, and mismatch of porous silicon , 2002 .

[18]  A. Uhlir.  Electrolytic shaping of germanium and silicon , 1956 .

[19]  Nicolas H Voelcker,et al.  Porous silicon biosensors on the advance. , 2009, Trends in biotechnology.

[20]  A. Vaseashta,et al.  Nanostructured and nanoscale devices, sensors and detectors , 2005 .

[21]  Mauro Ferrari,et al.  Mesoporous silicon particles as a multistage delivery system for imaging and therapeutic applications. , 2008, Nature nanotechnology.

[22]  A. Halimaoui,et al.  Electroluminescence in the visible range during anodic oxidation of porous silicon films , 1991 .

[23]  R. J. Archer.  Stain films on silicon , 1960 .

[24]  Jillian M Buriak,et al.  Organometallic chemistry on silicon and germanium surfaces. , 2002, Chemical reviews.

[25]  Mihrimah Ozkan,et al.  Quantum dots and other nanoparticles: what can they offer to drug discovery? , 2004, Drug discovery today.

[26]  W. R. Moore,et al.  Synthetic bone graft substitutes , 2001, ANZ journal of surgery.

[27]  Philippe M. Fauchet,et al.  Porous silicon as a cell interface for bone tissue engineering , 2007 .

[28]  J. Devoisselle,et al.  Inclusion of ibuprofen in mesoporous templated silica: drug loading and release property. , 2004, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

[29]  Michael J. Sailor,et al.  Chemical Modification of Crystalline Porous Silicon Surfaces , 1999 .

[30]  Nobuyoshi Koshida,et al.  Visible electroluminescence from porous silicon , 1992 .

[31]  Hans Lüth,et al.  Investigation and design of optical properties of porosity superlattices , 1995 .

[32]  Nicolas H Voelcker,et al.  The biocompatibility of porous silicon in tissues of the eye. , 2009, Biomaterials.

[33]  S. Ossicini,et al.  Porous silicon: a quantum sponge structure for silicon based optoelectronics , 2000 .

[34]  Leigh Trevor Canham,et al.  Will a chip every day keep the doctor away , 2001 .

[35]  P. Kohl,et al.  Mechanism of (111) Silicon Etching in HF ‐ Acetonitrile , 1995 .

[36]  J L West,et al.  Applications of nanotechnology to biotechnology commentary. , 2000, Current opinion in biotechnology.

[37]  Z. Tang,et al.  Bioapplication of nanosemiconductors , 2005 .

[38]  Stephan Frohnhoff,et al.  Porous silicon superlattices , 1994 .

[39]  A. G. Cullis,et al.  The structural and luminescence properties of porous silicon , 1997 .

[40]  Pellegrini,et al.  Enhanced optical properties in porous silicon microcavities. , 1995, Physical review. B, Condensed matter.

[41]  Robert Langer,et al.  Small-scale systems for in vivo drug delivery , 2003, Nature Biotechnology.

[42]  S. Lölkes,et al.  Large area etching for porous semiconductors , 2005 .

[43]  Raúl J. Martín-Palma,et al.  Surface biofunctionalization of materials by amine groups , 2004 .

[44]  H. Föll,et al.  Formation and application of porous silicon , 2002 .

[45]  J. Salonen,et al.  Studies of Thermally‐Carbonized Porous Silicon Surfaces , 2000 .

[46]  E. Fabrizio,et al.  Porous silicon as drug carrier for controlled delivery of doxorubicin anticancer agent , 2006 .

[47]  L. Canham.  Silicon quantum wire array fabrication by electrochemical and chemical dissolution of wafers , 1990 .

[48]  K. Burg,et al.  Biomaterial developments for bone tissue engineering. , 2000, Biomaterials.

[49]  Peter W. Swaan,et al.  Microfabricated Porous Silicon Particles Enhance Paracellular Delivery of Insulin Across Intestinal Caco-2 Cell Monolayers , 2004, Pharmaceutical Research.

[50]  Philippe M. Fauchet,et al.  Nano‐ to Microscale Porous Silicon as a Cell Interface for Bone‐Tissue Engineering , 2007 .

[51]  Michael J. Sailor,et al.  Compatibility of Primary Hepatocytes with Oxidized Nanoporous Silicon , 2001 .

[52]  J. Salonen,et al.  Mesoporous silicon in drug delivery applications. , 2008, Journal of pharmaceutical sciences.

[53]  Vesa-Pekka Lehto,et al.  Fabrication and chemical surface modification of mesoporous silicon for biomedical applications , 2008 .

[54]  S. D. Collins,et al.  Porous silicon formation mechanisms , 1992 .

[55]  H. Kaabi,et al.  Vapour-etching-based porous silicon: a new approach , 2002 .

[56]  Volker Lehmann,et al.  Electrochemistry of Silicon , 2002 .

[57]  W. Freeman,et al.  Porous silicon in drug delivery devices and materials. , 2008, Advanced drug delivery reviews.

[58]  Michael J. Sailor,et al.  Surface chemistry of Luminescent Silicon Nanocrystallites , 1997 .

[59]  Michael J Sailor,et al.  Biodegradable luminescent porous silicon nanoparticles for in vivo applications. , 2009, Nature materials.