Evaluation of drugs of abuse use and trends in a prison through wastewater analysis.

Illicit drugs and metabolites have been recognized recently as a group of emerging contaminants of concern, as a consequence of their high volumes of use and production. Drug residue levels in the aquatic environment have also been pointed out as good indicators of illicit drug abuse. The present work assesses for the first time drug abuse in a penal complex from the levels of different drug residues measured in the prison sewage waters and evaluates the suitability of this approach to track and control illicit drug usage in such facilities. The presence of various drugs of abuse and metabolites in sewage waters from a penal complex was determined by an analytical method based on on-line solid phase extraction-liquid chromatography-tandem mass spectrometry. Levels of consumption indicators measured in this water were used to back-calculate drugs usage in the penal complex. Daily use was observed for methadone (average of 156 doses/day/1000 inh), alprazolam (129 doses/day/1000 inh), ephedrine (46 doses/day/1000 inh), cannabis (33 doses/day/1000 inh.) and cocaine (3 doses/day/1000 inh). Sporadic consumption was observed for heroin, amphetamine, methamphetamine, and ecstasy. In spite of the fact that this and other sewage epidemiological approaches described may suffer from bias that still need to be investigated and refined, it provides near "real-time" information on collective drug use in an anonymous way and constitutes a very useful, economic and fast tool to evaluate the efficiency of measures adopted to control and track drug abuse in this type of facilities (or any other provided that has a STP associated or an accessible collector system).

[1]  J. Coid,et al.  Drug use and initiation in prison: results from a national prison survey in England and Wales. , 2002, Addiction.

[2]  Damià Barceló,et al.  Fully automated determination in the low nanogram per liter level of different classes of drugs of abuse in sewage water by on-line solid-phase extraction-liquid chromatography-electrospray-tandem mass spectrometry. , 2008, Analytical chemistry.

[3]  A. Cailleux,et al.  Determination of LSD and its metabolites in human biological fluids by high-performance liquid chromatography with electrospray tandem mass spectrometry. , 2001, Journal of chromatography. B, Biomedical sciences and applications.

[4]  Luc de Montigny,et al.  The spatial epidemiology of cocaine, methamphetamine and 3,4-methylenedioxymethamphetamine (MDMA) use: a demonstration using a population measure of community drug load derived from municipal wastewater. , 2009, Addiction.

[5]  R. Foltz,et al.  Chromatographic and mass spectrometric methods for determination of lysergic acid diethylamide (LSD) and metabolites in body fluids. , 1992, Journal of chromatography.

[6]  D. Barceló,et al.  Drugs of abuse and their metabolites in the Ebro River basin: occurrence in sewage and surface water, sewage treatment plants removal efficiency, and collective drug usage estimation. , 2010, Environment international.

[7]  Ronny Blust,et al.  Cocaine and metabolites in waste and surface water across Belgium. , 2009, Environmental pollution.

[8]  Peter R Mills.  The development of a new corporate specific health risk measurement instrument, and its use in investigating the relationship between health and well-being and employee productivity , 2005, Environmental health : a global access science source.

[9]  Lisieux E B Telles,et al.  [Alcohol, drugs and crime]. , 2006, Revista brasileira de psiquiatria.

[10]  T. Seddon.  Explaining the Drug–Crime Link: Theoretical, Policy and Research Issues , 2000, Journal of Social Policy.

[11]  M. Trace.  Tackling drug use in prison: a success story , 1998 .

[12]  Katrin Baumgartner,et al.  World Drug Report 2000 , 2000 .

[13]  Penelope Green.  Drugs in Prison , 1999 .

[14]  C. Mccoy,et al.  The Drugs-Crime Relationship: An Analytical Framework , 1993 .

[15]  F. Ventura,et al.  Monitoring of opiates, cannabinoids and their metabolites in wastewater, surface water and finished water in Catalonia, Spain. , 2009, Water research.

[16]  R. Dinsdale,et al.  Illicit drugs and pharmaceuticals in the environment--forensic applications of environmental data. Part 1: Estimation of the usage of drugs in local communities. , 2009, Environmental pollution.

[17]  K. McCullough,et al.  Drug treatment behind bars: Prison-based strategies for change , 1997 .

[18]  S. Gravett.  Drugs in Prison , 2000 .

[19]  Ettore Zuccato,et al.  Estimating Community Drug Abuse by Wastewater Analysis , 2008, Environmental health perspectives.

[20]  F. Ventura,et al.  Occurrence of psychoactive stimulatory drugs in wastewaters in north-eastern Spain. , 2008, The Science of the total environment.

[21]  B. Paull,et al.  Using environmental analytical data to estimate levels of community consumption of illicit drugs and abused pharmaceuticals. , 2007, Journal of environmental monitoring : JEM.

[22]  D. Barceló,et al.  Analysis of drugs of abuse and their human metabolites in water by LC-MS2: A non-intrusive tool for drug abuse estimation at the community level , 2008 .