LRP5 sequence and polymorphisms in the baboon

Background  LRP5 is known to have an important relationship with bone density and a variety of other biological processes. Mapping to human chromosome 11q13.2, LRP5 shows considerable evolutionary conservation. Orthologs of this gene exist in many species, although comparison of human LRP5 with other non‐human primates has not been performed until now.

[1]  J. Rogers,et al.  A second-generation genetic linkage map of the baboon (Papio hamadryas) genome. , 2006, Genomics.

[2]  Zhenlin Zhang,et al.  Association of polymorphisms in low-density lipoprotein receptor-related protein 5 gene with bone mineral density in postmenopausal Chinese women , 2005, Acta Pharmacologica Sinica.

[3]  T. Tahira,et al.  Complexity of the genotype–phenotype correlation in familial exudative vitreoretinopathy with mutations in the LRP5 and/or FZD4 genes , 2005, Human mutation.

[4]  J. Rogers,et al.  A quantitative trait locus for normal variation in forearm bone mineral density in pedigreed baboons maps to the ortholog of human chromosome 11q. , 2005, The Journal of clinical endocrinology and metabolism.

[5]  R. Baron,et al.  Interaction between LRP5 and Frat1 Mediates the Activation of the Wnt Canonical Pathway* , 2005, Journal of Biological Chemistry.

[6]  M. Trese,et al.  Autosomal recessive familial exudative vitreoretinopathy is associated with mutations in LRP5. , 2004, American journal of human genetics.

[7]  Daniel L. Koller,et al.  Contribution of the LRP5 Gene to Normal Variation in Peak BMD in Women , 2004, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[8]  A. Uitterlinden,et al.  Influence of LRP5 Polymorphisms on Normal Variation in BMD , 2004, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[9]  E. Dermitzakis,et al.  Polymorphisms in the low-density lipoprotein receptor-related protein 5 (LRP5) gene are associated with variation in vertebral bone mass, vertebral bone size, and stature in whites. , 2004, American journal of human genetics.

[10]  Michael J Parker,et al.  Mutations in LRP5 or FZD4 underlie the common familial exudative vitreoretinopathy locus on chromosome 11q. , 2004, American journal of human genetics.

[11]  A. Huvos,et al.  Expression of LDL receptor‐related protein 5 (LRP5) as a novel marker for disease progression in high‐grade osteosarcoma , 2004, International journal of cancer.

[12]  N. Niikawa,et al.  LRP5, low-density-lipoprotein-receptor-related protein 5, is a determinant for bone mineral density , 2004, Journal of Human Genetics.

[13]  H. Varmus,et al.  Wnt/Wingless signaling through β-catenin requires the function of both LRP/Arrow and frizzled classes of receptors , 2003, BMC Cell Biology.

[14]  M. Metzker,et al.  Linkage and association mapping of the LRP5 locus on chromosome 11q13 in type 1 diabetes , 2003, Human Genetics.

[15]  F. Shanahan,et al.  Suggestive Linkage of 2p22-25 and 11q12-13 with Low Bone Mineral Density at the Lumbar Spine in the Irish Population , 2003, Calcified Tissue International.

[16]  M. Ono,et al.  Severe Hypercholesterolemia, Impaired Fat Tolerance, and Advanced Atherosclerosis in Mice Lacking Both Low Density Lipoprotein Receptor-related Protein 5 and Apolipoprotein E* , 2003, The Journal of Biological Chemistry.

[17]  Leonid Kalichman,et al.  Cortical index and size of hand bones: segregation analysis and linkage with the 11q12-13 segment. , 2003, Medical science monitor : international medical journal of experimental and clinical research.

[18]  Jens Bollerslev,et al.  Six novel missense mutations in the LDL receptor-related protein 5 (LRP5) gene in different conditions with an increased bone density. , 2003, American journal of human genetics.

[19]  Masato Nose,et al.  Low-density lipoprotein receptor-related protein 5 (LRP5) is essential for normal cholesterol metabolism and glucose-induced insulin secretion , 2002, Proceedings of the National Academy of Sciences of the United States of America.

[20]  Joseph L. Goldstein,et al.  Structure of the LDL Receptor Extracellular Domain at Endosomal pH , 2002, Science.

[21]  Daniel L. Koller,et al.  Sibling pair linkage and association studies between peak bone mineral density and the gene locus for the osteoclast-specific subunit (OC116) of the vacuolar proton pump on chromosome 11p12-13. , 2002, The Journal of clinical endocrinology and metabolism.

[22]  J. Bollerslev,et al.  Localization of the Gene Causing Autosomal Dominant Osteopetrosis Type I to Chromosome 11q12‐13 , 2002, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[23]  Richard P Lifton,et al.  High bone density due to a mutation in LDL-receptor-related protein 5. , 2002, The New England journal of medicine.

[24]  Miikka Vikkula,et al.  LDL Receptor-Related Protein 5 (LRP5) Affects Bone Accrual and Eye Development , 2001, Cell.

[25]  C. Jerome,et al.  Nonhuman primate models in skeletal research. , 2001, Bone.

[26]  R. Brommage Perspectives on using nonhuman primates to understand the etiology and treatment of postmenopausal osteoporosis. , 2001, Journal of musculoskeletal & neuronal interactions.

[27]  G A Tomlinson,et al.  Bone mineral density, osteopenia, and osteoporosis in the rhesus macaques of Cayo Santiago. , 2000, American journal of physical anthropology.

[28]  J. Todd,et al.  Expression of the Type I Diabetes-associated Gene LRP5 in Macrophages, Vitamin A System Cells, and the Islets of Langerhans Suggests Multiple Potential Roles in Diabetes , 2000, The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society.

[29]  Daniel L. Koller,et al.  Genome screen for QTLs contributing to normal variation in bone mineral density and osteoporosis. , 2000, The Journal of clinical endocrinology and metabolism.

[30]  J. Rogers,et al.  A genetic linkage map of the baboon (Papio hamadryas) genome based on human microsatellite polymorphisms. , 2000, Genomics.

[31]  Daniel L. Koller,et al.  Linkage of a QTL Contributing to Normal Variation in Bone Mineral Density to Chromosome 11q12–13 , 1998, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[32]  T. Springer,et al.  An extracellular beta-propeller module predicted in lipoprotein and scavenger receptors, tyrosine kinases, epidermal growth factor precursor, and extracellular matrix components. , 1998, Journal of molecular biology.

[33]  E. Orwoll,et al.  Quantitative Trait Loci Affecting Peak Bone Mineral Density in Mice , 1998, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[34]  Michele D'Urso,et al.  Autosomal recessive familial exudative vitreoretinopathy: evidence for genetic heterogeneity , 1998, Clinical genetics.

[35]  V. Sheffield,et al.  Human autosomal recessive osteopetrosis maps to 11q13, a position predicted by comparative mapping of the murine osteosclerosis (oc) mutation. , 1998, Human molecular genetics.

[36]  M. Metzker,et al.  Cloning of a novel member of the low-density lipoprotein receptor family. , 1998, Gene.

[37]  Mark L. Johnson,et al.  Linkage of a gene causing high bone mass to human chromosome 11 (11q12-13) , 1997, American journal of human genetics.

[38]  C. Kammerer,et al.  Effects of age, sex, and heredity on measures of bone mass in baboons (Papio hamadryas) , 1995, Journal of medical primatology.

[39]  G. Holt,et al.  A non-human primate model for the study of osteoporosis and oral bone loss. , 1993, Bone.

[40]  C. J. Derousseau Aging in the musculoskeletal system of rhesus monkeys: III. Bone loss. , 1985, American journal of physical anthropology.

[41]  T. Pullaiah Reproductive biology , 2008, Nature Medicine.

[42]  Mark L. Johnson,et al.  Parameters of LRP5 from a structural and molecular perspective. , 2005, Critical reviews in eukaryotic gene expression.

[43]  V. Chan,et al.  A family with osteoporosis-pseudoglioma syndrome (OPG) due to compound heterozygous mutation of the LRO5 gene , 2004 .

[44]  Mark L. Johnson,et al.  A mutation in the LDL receptor-related protein 5 gene results in the autosomal dominant high-bone-mass trait. , 2002, American journal of human genetics.

[45]  H. Mcgill,et al.  Effect of naturally reduced ovarian function on plasma lipoprotein and 27-hydroxycholesterol levels in baboons (Papio sp.). , 1998, Atherosclerosis.

[46]  A. Hendrickx Chapter 9 – Reproductive Biology , 1995 .