Enhancement of tolerance of abiotic stress by metabolic engineering of betaines and other compatible solutes.

[1]  K. Shinozaki,et al.  Antisense suppression of proline degradation improves tolerance to freezing and salinity in Arabidopsis thaliana , 1999, FEBS letters.

[2]  S. Imamura,et al.  Purification and characterization of choline oxidase from Arthrobacter globiformis. , 1977, Journal of biochemistry.

[3]  A. Sakamoto,et al.  The role of glycine betaine in the protection of plants from stress: clues from transgenic plants. , 2002, Plant, cell & environment.

[4]  H. Hayashi,et al.  Enhancement of the tolerance of Arabidopsis to high temperatures by genetic engineering of the synthesis of glycinebetaine. , 1998, The Plant journal : for cell and molecular biology.

[5]  A. Sakamoto,et al.  The use of bacterial choline oxidase, a glycinebetaine-synthesizing enzyme, to create stress-resistant transgenic plants. , 2001, Plant physiology.

[6]  O. Schabenberger,et al.  Arabidopsis CBF1 overexpression induces COR genes and enhances freezing tolerance. , 1998, Science.

[7]  H. Bohnert,et al.  Enhancement of seed germination in high salinity by engineering mannitol expression in Arabidopsis thaliana , 1995 .

[8]  E. Pilon-Smits,et al.  Enhanced drought resistance in fructan-producing sugar beet , 1999 .

[9]  H. Hayashi,et al.  Transformation of Arabidopsis thaliana with the codA gene for choline oxidase; accumulation of glycinebetaine and enhanced tolerance to salt and cold stress. , 1997, The Plant journal : for cell and molecular biology.

[10]  S. Allakhverdiev,et al.  Oxidative stress inhibits the repair of photodamage to the photosynthetic machinery , 2001, The EMBO journal.

[11]  A. Hanson,et al.  The endogenous choline supply limits glycine betaine synthesis in transgenic tobacco expressing choline monooxygenase. , 1998, The Plant journal : for cell and molecular biology.

[12]  G. Papageorgiou,et al.  The unusually strong stabilizing effects of glycine betaine on the structure and function of the oxygen-evolving Photosystem II complex , 1995, Photosynthesis Research.

[13]  A. Hanson,et al.  Quaternary Ammonium and Tertiary Sulfonium Compounds in Higher Plants , 1993 .

[14]  R. Valverde,et al.  Transformation of Arabidopsis with the codA gene for choline oxidase enhances freezing tolerance of plants. , 2000, The Plant journal : for cell and molecular biology.

[15]  P. Ozias‐Akins,et al.  Salinity and drought tolerance of mannitol‐accumulating transgenic tobacco , 1997 .

[16]  W. Keller,et al.  Genetic engineering of glycinebetaine production toward enhancing stress tolerance in plants: metabolic limitations. , 2000, Plant physiology.

[17]  D. Verma,et al.  Removal of feedback inhibition of delta(1)-pyrroline-5-carboxylate synthetase results in increased proline accumulation and protection of plants from osmotic stress. , 2000, Plant physiology.

[18]  A. Strøm,et al.  Choline-glycine betaine pathway confers a high level of osmotic tolerance in Escherichia coli , 1986, Journal of bacteriology.

[19]  P. Kumar,et al.  Transformation of Brassica juncea (L.) Czern with bacterial codA gene enhances its tolerance to salt stress , 2000, Molecular Breeding.

[20]  A. Hanson,et al.  Choline import into chloroplasts limits glycine betaine synthesis in tobacco: analysis of plants engineered with a chloroplastic or a cytosolic pathway. , 2000, Metabolic engineering.

[21]  A. Sakamoto,et al.  Metabolic engineering of rice leading to biosynthesis of glycinebetaine and tolerance to salt and cold , 1998, Plant Molecular Biology.

[22]  L. Bülow,et al.  Enhanced NaCl Stress Tolerance in Transgenic Tobacco Expressing Bacterial Choline Dehydrogenase , 1996, Bio/Technology.

[23]  A. Hanson,et al.  Enhanced synthesis of choline and glycine betaine in transgenic tobacco plants that overexpress phosphoethanolamine N-methyltransferase , 2001, Proceedings of the National Academy of Sciences of the United States of America.

[24]  N. Smirnoff,et al.  Hydroxyl radical scavenging activity of compatible solutes , 1989 .

[25]  H. Kwon,et al.  Genetic engineering of drought resistant potato plants by introduction of the trehalose-6-phosphate synthase (TPS1) gene from Saccharomyces cerevisiae. , 2000, Molecules and cells.

[26]  A. Hanson,et al.  Choline monooxygenase, an unusual iron-sulfur enzyme catalyzing the first step of glycine betaine synthesis in plants: prosthetic group characterization and cDNA cloning. , 1997, Proceedings of the National Academy of Sciences of the United States of America.

[27]  H. Bohnert,et al.  Increased Salt and Drought Tolerance by D-Ononitol Production in Transgenic Nicotiana tabacum L , 1997, Plant physiology.

[28]  Yeo Et,et al.  Genetic engineering of drought resistant potato plants by introduction of the trehalose-6-phosphate synthase (TPS1) gene from Saccharomyces cerevisiae. , 2000, Molecules and cells.

[29]  P. Weisbeek,et al.  Improved Performance of Transgenic Fructan-Accumulating Tobacco under Drought Stress , 1995, Plant physiology.

[30]  A. Mandal,et al.  Improved tolerance to salinity and low temperature in transgenic tobacco producing glycine betaine. , 2000, Journal of experimental botany.

[31]  E. T. Palva,et al.  Drought tolerance in tobacco , 1996, Nature.

[32]  T. Reinikainen,et al.  Extreme Halophiles Synthesize Betaine from Glycine by Methylation* , 2000, The Journal of Biological Chemistry.

[33]  A. Sakamoto,et al.  Genetic engineering of glycinebetaine synthesis in plants: current status and implications for enhancement of stress tolerance. , 2000, Journal of experimental botany.

[34]  H. Hayashi,et al.  Enhanced tolerance to light stress of transgenic Arabidopsis plants that express the codA gene for a bacterial choline oxidase , 1999, Plant Molecular Biology.

[35]  W. P. Chen,et al.  Glycinebetaine increases chilling tolerance and reduces chilling‐induced lipid peroxidation in Zea mays L. , 2000 .

[36]  Y. Shachar-Hill,et al.  Metabolic modeling identifies key constraints on an engineered glycine betaine synthesis pathway in tobacco. , 2000, Plant physiology.

[37]  Nicholas Smirnoff,et al.  The role of active oxygen in the response of plants to water deficit and desiccation. , 1993, The New phytologist.

[38]  R. Tao,et al.  Transformation of Japanese persimmon (Diospyros kaki Thunb.) with a bacterial gene for choline oxidase , 2000, Molecular Breeding.

[39]  M. Nuccio,et al.  Betaines and related osmoprotectants. Targets for metabolic engineering of stress resistance , 1999, Plant physiology.

[40]  Sheveleva,et al.  Sorbitol-6-phosphate dehydrogenase expression in transgenic tobacco. High amounts of sorbitol lead to necrotic lesions , 1998, Plant physiology.

[41]  R. Tao,et al.  Transformation of Japanese persimmon (Diospyros kaki Thunb.) with apple cDNA encoding NADP-dependent sorbitol-6-phosphate dehydrogenase. , 2001, Plant science : an international journal of experimental plant biology.

[42]  H. Hayashi,et al.  Transformation of Synechococcus with a gene for choline oxidase enhances tolerance to salt stress , 1995, Plant Molecular Biology.

[43]  A. Zayed,et al.  Trehalose-producing transgenic tobacco plants show improved growth performance under drought stress , 1998 .

[44]  Gao Yin,et al.  Construction of a Trehalose-6-phosphate Synthase Gene Driven by Drought-responsive Promoter and Expression of Drought-resistance in Transgenic Tobacco , 2000 .

[45]  H. Hayashi,et al.  Transformation with a gene for choline oxidase enhances the cold tolerance of Arabidopsis during germination and early growth , 1998 .

[46]  S. Heckathorn,et al.  Mitochondrial adaptations to NaCl. Complex I is protected by anti-oxidants and small heat shock proteins, whereas complex II is protected by proline and betaine. , 2001, Plant physiology.

[47]  H. Bohnert,et al.  Stress Protection of Transgenic Tobacco by Production of the Osmolyte Mannitol , 1993, Science.

[48]  Z. Hui Construction of a Trehalose-6-phosphate Synthase Gene Driven by Drought-responsive Promoter and Expression of Drought-resistance in Transgenic Tobacco , 2000 .

[49]  H. Bohnert,et al.  Increased Resistance to Oxidative Stress in Transgenic Plants by Targeting Mannitol Biosynthesis to Chloroplasts , 1997, Plant physiology.

[50]  H. Bohnert,et al.  Expression of a bacterial mtlD gene in transgenic tobacco leads to production and accumulation of mannitol. , 1992, Proceedings of the National Academy of Sciences of the United States of America.

[51]  G. Selvaraj,et al.  Choline oxidase, a catabolic enzyme in Arthrobacter pascens, facilitates adaptation to osmotic stress in Escherichia coli , 1991, Journal of bacteriology.