Ability of cytokine responses to discriminate between LTBI and uninfected controls

Howe, R.; Mihret, A.; Loxton, A.G.; Sheehama, J.; Kassa, D.; Crampin, A.C.; Dockrell, H.M.; Kidd, M.; Rosenkrands, I.; Geluk, A.; Ottenhoff, T.H.; Corstjens, P.L.; Chegou, N.N.; Walzl, G.; AE-TBC Consortium, .; , COLLABORATORS; Walzl, G.; Chegou, N.N.; Kriel, M.; van der Spuy, G.; Loxton, A.G.; Stanley, K.; Malherbe, S.; Mcanda, S.; Kriel, B.; Phalane, K.G.; Essone, P.; Sutherland, J.S.; Owolabi, O.; Sillah, A.; Mendy, J.; Gindeh, A.; Donkor, S.; Togun, T.; Ota, M.; Crampin, A.C.; Simukonda, F.; Amberbir, A.; Chilongo, F.; Houben, R.; Kassa, D.; Gebrezgeabher, A.; Mesfin, G.; Belay, Y.; Gebremichael, G.; Alemayehu, Y.; van der Vyver, M.; Amutenya, F.N.; Nelongo, J.N.; Monye, L.; Sheehama, J.A.; Iipinge, S.; Mayanja-Kizza, H.; Namuganga, A.R.; Muzanye, G.; Nsereko, M.; Peters, P.; Howe, R.; Mihret, A.; Bekele, Y.; Tessema, B.; Yamuah, L.; Ottenhoff, T.H.; Geluk, A.; Franken, K.; Corstjens, P.L.; Tjon Kon Fat, E.M.; de Dood, C.J.; van der Ploeg-van Schip, J.J.; Rosenkrands, I.; Aagaard, C.; Kaufmann, S.H.; Esterhuyse, M.M.; Cliff, J.M.; Dockrell, H.M. (2016) [Accepted Manuscript] Evaluation of cytokine responses against novel Mtb antigens as diagnostic markers for TB disease. The Journal of infection. ISSN 0163-4453 DOI: https://doi.org/10.1016/j.jinf.2016.04.036 (In Press)

[1]  S. Kaufmann,et al.  Diagnostic performance of a seven-marker serum protein biosignature for the diagnosis of active TB disease in African primary healthcare clinic attendees with signs and symptoms suggestive of TB , 2016, Thorax.

[2]  K. Stanley,et al.  Host biomarkers detected in saliva show promise as markers for the diagnosis of pulmonary tuberculosis disease and monitoring of the response to tuberculosis treatment. , 2016, Cytokine.

[3]  Elisa M. Tjon Kon Fat,et al.  Multi-center evaluation of a user-friendly lateral flow assay to determine IP-10 and CCL4 levels in blood of TB and non-TB cases in Africa. , 2016, Clinical biochemistry.

[4]  Gerhard Walzl,et al.  Serologic diagnosis of tuberculosis by combining Ig classes against selected mycobacterial targets. , 2014, The Journal of infection.

[5]  T. Ottenhoff,et al.  The in vivo expressed Mycobacterium tuberculosis (IVE-TB) antigen Rv2034 induces CD4⁺ T-cells that protect against pulmonary infection in HLA-DR transgenic mice and guinea pigs. , 2014, Vaccine.

[6]  Elisa M. Tjon Kon Fat,et al.  Field-Evaluation of a New Lateral Flow Assay for Detection of Cellular and Humoral Immunity against Mycobacterium leprae , 2014, PLoS neglected tropical diseases.

[7]  Andrea De Maria,et al.  Immunology of Tuberculosis , 2014, Mediterranean journal of hematology and infectious diseases.

[8]  K. Stanley,et al.  Differential Expression of Host Biomarkers in Saliva and Serum Samples from Individuals with Suspected Pulmonary Tuberculosis , 2013, Mediators of inflammation.

[9]  Sang-Nae Cho,et al.  Efficacy of inducible protein 10 as a biomarker for the diagnosis of tuberculosis. , 2012, International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases.

[10]  T. Ottenhoff.  New pathways of protective and pathological host defense to mycobacteria. , 2012, Trends in microbiology.

[11]  S. Kaufmann,et al.  Potential of Host Markers Produced by Infection Phase-Dependent Antigen-Stimulated Cells for the Diagnosis of Tuberculosis in a Highly Endemic Area , 2012, PloS one.

[12]  A. Raja,et al.  Interferon gamma and interferon gamma inducible protein-10 in detecting tuberculosis infection. , 2012, The Journal of infection.

[13]  S. Kaufmann,et al.  Potential of novel Mycobacterium tuberculosis infection phase-dependent antigens in the diagnosis of TB disease in a high burden setting , 2012, BMC Infectious Diseases.

[14]  J. Drijfhout,et al.  Double‐ and monofunctional CD4+ and CD8+ T‐cell responses to Mycobacterium tuberculosis DosR antigens and peptides in long‐term latently infected individuals , 2011, European journal of immunology.

[15]  N. Dendukuri,et al.  Systematic Review and Meta-Analysis of Antigen Detection Tests for the Diagnosis of Tuberculosis , 2011, Clinical and Vaccine Immunology.

[16]  D. van Soolingen,et al.  Application of modern microbiological diagnostic methods for tuberculosis in Macha, Zambia. , 2010, The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease.

[17]  B. L. dos Anjos,et al.  Evaluation of C-reactive protein and serum amyloid A in the detection of inflammatory and infectious diseases in children , 2010, Clinical chemistry and laboratory medicine.

[18]  Venkatesan Perumal,et al.  Role of QuantiFERON-TB Gold, Interferon Gamma Inducible Protein-10 and Tuberculin Skin Test in Active Tuberculosis Diagnosis , 2010, PloS one.

[19]  G. Schoolnik,et al.  Immunogenicity of Novel DosR Regulon-Encoded Candidate Antigens of Mycobacterium tuberculosis in Three High-Burden Populations in Africa , 2009, Clinical and Vaccine Immunology.

[20]  Gerhard Walzl,et al.  Host markers in Quantiferon supernatants differentiate active TB from latent TB infection: preliminary report , 2009, BMC pulmonary medicine.

[21]  T. Bodmer,et al.  Evaluating the potential of IP-10 and MCP-2 as biomarkers for the diagnosis of tuberculosis , 2008, European Respiratory Journal.

[22]  T. Ottenhoff,et al.  Not to wake a sleeping giant: new insights into host-pathogen interactions identify new targets for vaccination against latent Mycobacterium tuberculosis infection , 2008, Biological chemistry.

[23]  N. Ariel,et al.  Whole genome identification of Mycobacterium tuberculosis vaccine candidates by comprehensive data mining and bioinformatic analyses , 2008, BMC Medical Genomics.

[24]  M. Pai,et al.  The new IGRA and the old TST: making good use of disagreement. , 2007, American journal of respiratory and critical care medicine.

[25]  T. Ottenhoff,et al.  Immunogenicity of Eight Dormancy Regulon-Encoded Proteins of Mycobacterium tuberculosis in DNA-Vaccinated and Tuberculosis-Infected Mice , 2006, Infection and Immunity.

[26]  M. Wolzt,et al.  C‐reactive protein is expressed and secreted by peripheral blood mononuclear cells , 2006, Clinical and experimental immunology.

[27]  G. Schoolnik,et al.  Human T-cell responses to 25 novel antigens encoded by genes of the dormancy regulon of Mycobacterium tuberculosis. , 2006, Microbes and infection.

[28]  P. Maasilta,et al.  Serum levels of C-reactive protein in patients with pulmonary tuberculosis and malignant tumors of the chest , 2005, Infection.

[29]  H. Dockrell,et al.  Cytokine profiles using whole-blood assays can discriminate between tuberculosis patients and healthy endemic controls in a BCG-vaccinated population. , 2002, Journal of immunological methods.

[30]  John Chan,et al.  Tuberculosis: Latency and Reactivation , 2001, Infection and Immunity.

[31]  S. Kaufmann,et al.  The many faces of host responses to tuberculosis , 2001, Immunology.

[32]  C. Sohaskey,et al.  Nonreplicating persistence of mycobacterium tuberculosis. , 2001, Annual review of microbiology.

[33]  S. Urieli-Shoval,et al.  Expression of apolipoprotein serum amyloid A mRNA in human atherosclerotic lesions and cultured vascular cells: implications for serum amyloid A function. , 1994, Proceedings of the National Academy of Sciences of the United States of America.