Primary splenic angiosarcoma with fever and anemia: a case report and literature review.

Primary splenic angiosarcoma is an extremely rare and aggressive neoplasm. The prognosis of this disease is dismal, and the mean survival is less than 6 months after the diagnosis. This neoplasm typically presents with abdominal pain, splenomegaly, weight loss, and spontaneous splenic rupture. Fever is a very rare presentation of splenic angiosarcoma. Here we report the case of a 64-year-old man who presented with fever and anemia. A laparoscopic splenectomy was performed and revealed splenic angiosarcoma. The postoperative course was uneventful and the patient received 5 cycles of adjuvant chemotherapy with ifosfamide plus epirubicin. He remained disease free at 9 months after surgery. This is the first case of splenic angiosarcoma with fever as the initial presentation that was treated with laparoscopic splenectomy to be reported in the English literature.

[1]  V. Shukla,et al.  Fever, anemia, and splenomegaly: A rare presentation of splenic angiosarcoma , 2011, Indian journal of medical and paediatric oncology : official journal of Indian Society of Medical & Paediatric Oncology.

[2]  K. Hamid,et al.  Primary Splenic Angiosarcoma , 2010, JSLS : Journal of the Society of Laparoendoscopic Surgeons.

[3]  A. Plotnik,et al.  Splenic angiosarcoma metastasis to the brain , 2008, Journal of Clinical Neuroscience.

[4]  H. Markogiannakis,et al.  Splenic rupture as the presenting manifestation of primary splenic angiosarcoma in a teenage woman: a case report , 2008, Journal of medical case reports.

[5]  G. Silecchia,et al.  Laparoscopic Splenectomy in the Management of Benign and Malignant Hematologic Diseases , 2006, JSLS : Journal of the Society of Laparoendoscopic Surgeons.

[6]  Chin-Yew Lin,et al.  Primary angiosarcoma of the spleen , 2005, Journal of surgical oncology.

[7]  Jinsong Liu,et al.  Angiosarcoma of the spleen clinically presenting as metastatic ovarian cancer. A case report and review of the literature. , 2005, Annals of diagnostic pathology.

[8]  C. Gomez-Fernandez,et al.  Fine-needle aspiration diagnosis of angiosarcoma of the spleen: a case report and review of the literature. , 2005, Archives of pathology & laboratory medicine.

[9]  W. M. Thompson,et al.  Angiosarcoma of the spleen: imaging characteristics in 12 patients. , 2005, Radiology.

[10]  G. Luna,et al.  Laparoscopic splenectomy for treatment of splenomegaly. , 2004, American journal of surgery.

[11]  L. Křen,et al.  Primary angiosarcoma of the spleen in a child. , 2003, Medical and pediatric oncology.

[12]  V. Canzonieri,et al.  Metastatic Angiosarcoma of the Spleen. A Case Report and Treatment Approach , 2001, Tumori.

[13]  H. Karakas,et al.  Primary angiosarcoma of the spleen: in vivo and in vitro MRI findings. , 2001 .

[14]  L. Thompson,et al.  Splenic Angiosarcoma: A Clinicopathologic and Immunophenotypic Study of 28 Cases , 2000, Modern Pathology.

[15]  S. Hai,et al.  Primary splenic angiosarcoma: case report and literature review. , 2000, Journal of the National Medical Association.

[16]  G. Anania,et al.  Laparoscopic versus open splenectomy in the management of splenomegaly: our preliminary experience. , 1998, Surgery.

[17]  E. Targarona,et al.  Splenomegaly should not be considered a contraindication for laparoscopic splenectomy. , 1998, Annals of surgery.

[18]  B. Choi,et al.  Primary Angiosarcoma of the Spleen , 1994, Acta radiologica.

[19]  J. Krishnan,et al.  Primary Angiosarcoma of the Spleen A Clinicopathologic Study of 40 Cases , 1993, The American journal of surgical pathology.

[20]  B. Mazières,et al.  [Association of T lymphoma localized at the sacrum and pulmonary sarcoidosis]. , 1991, Presse medicale.

[21]  B. Delaitre,et al.  [Splenectomy by the laparoscopic approach. Report of a case]. , 1991, Presse medicale.

[22]  M. Trigg,et al.  Angiosarcoma of the liver and spleen in an infant. , 1985, Pediatric pathology.

[23]  P. Sordillo,et al.  Primary hemangiosarcoma of the spleen: report of four cases. , 1981, Medical and pediatric oncology.

[24]  V. Caggiano,et al.  Primary hemangiosarcoma of the spleen associated with leukocytosis and abnormal spleen scan. , 1980, International surgery.