Cu2–xSe Nanocrystals with Localized Surface Plasmon Resonance as Sensitive Contrast Agents for In Vivo Photoacoustic Imaging: Demonstration of Sentinel Lymph Node Mapping

Abstract The promise of a new nanomaterial, Cu(2-x) Se nanocrystals, as a contrast agent for photoacoustic imaging is demonstrated. The Cu(2-x) Se nanocrystals exhibit strong optical absorption at near infrared wavelengths that can efficiently penetrate tissue. In vivo photoacoustic tomography using this nanomaterial as the contrast agent provides clear three-dimensional resolution of a sentinel lymph node in a rat model.

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