Severe uterine bleeding and degenerative skeletal-muscle changes in unrecognized myxedema.

Two cases of severe uterine bleeding associated with unrecognized myxedema are reported. Degenerative changes in skeletal muscles were suggested by the results of electromyographic studies and demonstrated by biopsy of a muscle prior to treatment in one patient. The uterine bleeding stopped promptly and a normal menstrual cycle was re-established in both patients after treatment with desiccated thyroid.