Comparing different electrode configurations using the 10-10 international system in tDCS: A finite element model analysis

For the past few years, the potential of transcranial direct current stimulation (tDCS) for the treatment of several pathologies has been investigated. Knowledge of the current density distribution is an important factor in optimizing such applications of tDCS. We use the finite element method to compare three different models in tDCS, where the stimulation electrodes (EEG electrodes) are placed in the 10-10 international system coordinates. We studied the focality and the distribution of the current density in depth and at the surface of the brain for three different electrode configurations. We show that the use of EEG electrodes increases the focality of tDCS, especially when one cathode and several anodes are used. Additionally, these electrodes need less injected current, can be placed at scalp positions whose relationship with the underlying cerebral cortex are known and allow the use of tDCS and EEG recording concomitantly.

[1]  D. A. Driscoll,et al.  Current Distribution in the Brain From Surface Electrodes , 1968, Anesthesia and analgesia.

[2]  Jan Geelen,et al.  Modelling motor cortex stimulation for chronic pain control: Electrical potential field, activating functions and responses of simple nerve fibre models , 2005, Medical and Biological Engineering and Computing.

[3]  Sergio P. Rigonatti,et al.  Transcranial direct current stimulation of the unaffected hemisphere in stroke patients , 2005, Neuroreport.

[4]  Cees J. Stok,et al.  The influence of model parameters on EEG/MEG single dipole source estimation , 1987, IEEE Transactions on Biomedical Engineering.

[5]  Frank Padberg,et al.  Skin lesions after treatment with transcranial direct current stimulation (tDCS) , 2008, Brain Stimulation.

[6]  M. Hallett,et al.  What does the ratio of injected current to electrode area tell us about current density in the brain during tDCS? , 2009, Clinical Neurophysiology.

[7]  M. Nitsche,et al.  Anticonvulsant Effects of Transcranial Direct‐current Stimulation (tDCS) in the Rat Cortical Ramp Model of Focal Epilepsy , 2006, Epilepsia.

[8]  M P Lomarev [Effect of transcranial polarization on the state of supraspinal mechanisms of regulation of muscle tonus in patients with Parkinson's disease]. , 1996, Fiziologiia cheloveka.

[9]  A. Antal,et al.  Safety aspects of transcranial direct current stimulation concerning healthy subjects and patients , 2007, Brain Research Bulletin.

[10]  J. Fermaglich Electric Fields of the Brain: The Neurophysics of EEG , 1982 .

[11]  David R. Wozny,et al.  The electrical conductivity of human cerebrospinal fluid at body temperature , 1997, IEEE Transactions on Biomedical Engineering.

[12]  S. Sato,et al.  Safety and cognitive effect of frontal DC brain polarization in healthy individuals , 2005, Neurology.

[13]  J. Born,et al.  Transcranial Direct Current Stimulation during Sleep Improves Declarative Memory , 2004, The Journal of Neuroscience.

[14]  M. Nitsche,et al.  Excitability changes induced in the human motor cortex by weak transcranial direct current stimulation , 2000, The Journal of physiology.

[15]  Á. Pascual-Leone,et al.  A Controlled Clinical Trial of Cathodal DC Polarization in Patients with Refractory Epilepsy , 2006, Epilepsia.

[16]  P. Nunez,et al.  Electric fields of the brain , 1981 .

[17]  Sergio P. Rigonatti,et al.  Treatment of major depression with transcranial direct current stimulation. , 2006, Bipolar disorders.

[18]  Dominique M. Durand,et al.  Toroidal coil models for transcutaneous magnetic simulation of nerves , 2001, IEEE Transactions on Biomedical Engineering.

[19]  Gottfried Schlaug,et al.  Contralateral and ipsilateral motor effects after transcranial direct current stimulation , 2006, Neuroreport.

[20]  Lomarev Mp,et al.  [Effect of transcranial polarization on the state of supraspinal mechanisms of regulation of muscle tonus in patients with Parkinson's disease]. , 1996 .

[21]  M. Nitsche,et al.  Shaping the effects of transcranial direct current stimulation of the human motor cortex. , 2007, Journal of neurophysiology.

[22]  F. H. Lopes da Silva,et al.  In vivo measurement of the brain and skull resistivities using an EIT-based method and the combined analysis of SEF/SEP data , 2003, IEEE Transactions on Biomedical Engineering.