PRELIMINARY OPINION ORAL EXPOSURE OF HUMANS TO THE BSE AGENT: INFECTIVE DOSE AND SPECIES BARRIER

[1]  M. Genuardi,et al.  Polymorphisms of the prion protein gene in Italian patients with Creutzfeldt-Jakob disease , 1994, Human Genetics.

[2]  A. Iavarone,et al.  A retrospective study of Creutzfeldt-Jakob disease in Italy (1972–1986) , 1988, European Journal of Epidemiology.

[3]  S. Prusiner,et al.  Compelling transgenetic evidence for transmission of bovine spongiform encephalopathy prions to humans. , 1999, Proceedings of the National Academy of Sciences of the United States of America.

[4]  I. Mcconnell,et al.  A single amino acid alteration (101L) introduced into murine PrP dramatically alters incubation time of transmissible spongiform encephalopathy , 1999, The EMBO journal.

[5]  L. Defebvre,et al.  Prominent psychiatric features and early onset in an inherited prion disease with a new insertional mutation in the prion protein gene. , 1999, Brain : a journal of neurology.

[6]  D. Dormont,et al.  Pathogenesis of the oral route of infection of mice with scrapie and bovine spongiform encephalopathy agents. , 1999, The Journal of general virology.

[7]  T. Werner,et al.  Analysis of 27 mammalian and 9 avian PrPs reveals high conservation of flexible regions of the prion protein. , 1999, Journal of molecular biology.

[8]  A. Aguzzi,et al.  PrP‐dependent association of prions with splenic but not circulating lymphocytes of scrapie‐infected mice , 1999, The EMBO journal.

[9]  M. Beekes,et al.  Pathological PrP is abundant in sympathetic and sensory ganglia of hamsters fed with scrapie , 1999, Neuroscience Letters.

[10]  C. Farrington,et al.  Deaths from variant Creutzfeldt-Jakob disease , 1999, The Lancet.

[11]  G. Wells,et al.  Limited detection of sternal bone marrow infectivity in the clinical phase of experimental bovine spongiform encephalopathy (BSE) , 1999, Veterinary Record.

[12]  F. Simone,et al.  Simultaneous occurrence of spongiform encephalopathy in a man and his cat in Italy , 1998, The Lancet.

[13]  F. Cohen,et al.  Eight prion strains have PrPSc molecules with different conformations , 1998, Nature Medicine.

[14]  A. Osterhaus,et al.  Studies on the efficacy of hyperbaric rendering procedures in inactivating bovine spongiform encephalopathy (BSE) and scrapie agents , 1998, Veterinary Record.

[15]  Richard C. Moore,et al.  Mice with gene targetted prion protein alterations show that Prnp, Sine and Prni are congruent , 1998, Nature Genetics.

[16]  G. Wells,et al.  Preliminary observations on the pathogenesis of experimental bovine spongiform encephalopathy (BSE): an update. , 1998, The Veterinary record.

[17]  F. Cohen,et al.  Identification of a prion protein epitope modulating transmission of bovine spongiform encephalopathy prions to transgenic mice. , 1997, Proceedings of the National Academy of Sciences of the United States of America.

[18]  P. Lansbury,et al.  Molecular assessment of the potential transmissibilities of BSE and scrapie to humans , 1997, Nature.

[19]  J. Rossier,et al.  Transmission of the BSE Agent to Mice in the Absence of Detectable Abnormal Prion Protein , 1997, Science.

[20]  S. Prusiner,et al.  Evidence for the Conformation of the Pathologic Isoform of the Prion Protein Enciphering and Propagating Prion Diversity , 1996, Science.

[21]  C. Locht,et al.  Immune system-dependent and -independent replication of the scrapie agent , 1996, Journal of virology.

[22]  M. Bruce.  Strain Typing Studies of Scrapie and BSE , 1996 .

[23]  D. Taylor,et al.  Inactivation of the bovine spongiform encephalopathy agent by rendering procedures , 1995, Veterinary Record.

[24]  L. Mucke,et al.  Neuron-specific expression of a hamster prion protein minigene in transgenic mice induces susceptibility to hamster scrapie agent , 1995, Neuron.

[25]  F. Cohen,et al.  Prion propagation in mice expressing human and chimeric PrP transgenes implicates the interaction of cellular PrP with another protein , 1995, Cell.

[26]  S. Prusiner,et al.  Complete Penetrance of Creutzfeldt-Jakob Disease in Libyan Jews Carrying the E200K Mutation in the Prion Protein Gene , 1995, Molecular medicine.

[27]  J. Laplanche,et al.  Molecular genetics of prion diseases in France , 1994, Neurology.

[28]  M. Bruce,et al.  Scrapie strain variation and mutation. , 1993, British medical bulletin.

[29]  H. Fraser.  Diversity in the neuropathology of scrapie-like diseases in animals. , 1993, British medical bulletin.

[30]  D. J. Middleton,et al.  Failure to transmit bovine spongiform encephalopathy to mice by feeding them with extraneural tissues of affected cattle , 1993, Veterinary Record.

[31]  I. Mcconnell,et al.  Are Sinc and the PrP gene congruent? Evidence from PrP gene analysis in Sinc congenic mice. , 1992, The Journal of general virology.

[32]  J. Aiken,et al.  PRP gene variability in the us cattle population , 1992 .

[33]  R. Carp,et al.  Scrapie-infected spleens: analysis of infectivity, scrapie-associated fibrils, and protease-resistant proteins. , 1991, The Journal of infectious diseases.

[34]  J. Gorham,et al.  Organ-specific modification of the dose-response relationship of scrapie infectivity. , 1990, The Journal of infectious diseases.

[35]  Stephen J. DeArmond,et al.  Transgenic mice expressing hamster prion protein produce species-specific scrapie infectivity and amyloid plaques , 1989, Cell.

[36]  P. McBride,et al.  Precise targeting of the pathology of the sialoglycoprotein, PrP, and vacuolar degeneration in mouse scrapie , 1989, Neuroscience Letters.

[37]  J. Foster,et al.  The unusual properties of CH1641, a sheep-passaged isolate of scrapie , 1988, Veterinary Record.

[38]  S. Prusiner,et al.  Molecular cloning of a human prion protein cDNA. , 1986, DNA.

[39]  Ruedi Aebersold,et al.  A cellular gene encodes scrapie PrP 27-30 protein , 1985, Cell.

[40]  D. Gajdusek,et al.  Creutzfeldt-Jakob disease in mice: persistent viremia and preferential replication of virus in low-density lymphocytes , 1983, Infection and immunity.

[41]  H. Fraser,et al.  Developmental Maturation of Susceptibility to Scrapie in Mice , 1973, Nature.

[42]  H. Fraser,et al.  The sequential development of the brain lesion of scrapie in three strains of mice. , 1968, Journal of comparative pathology.