论文信息 - The magnetization transfer effect in cerebral infarction.

The magnetization transfer effect in cerebral infarction.

PURPOSE To estimate the age of cerebral infarcts using magnetization transfer. METHODS Twelve patients with radiographically and clinically documented cortical and subcortical cerebral infarctions underwent MR imaging on a 0.1T magnet. Magnetization transfer contrast images were generated by application of off-resonance pulses to every other repetition time on intermediate-weighted images. The magnetization transfer effect was calculated by obtaining an intensity value in the region of interest within the infarcted area. RESULTS The data show a pattern in which the magnetization transfer effect decreases as the chronicity of the infarct increases. Infarcts less than 1 week old had an average magnetization transfer effect of 0.35. Those more than 1 week and less than 1 month old average 0.30. Infarcts more than 1 month and specifically those more than 1 year old averaged 0.16 or less. CONCLUSION Magnetization transfer offers the potential to estimate the age of cerebral infarcts.

[1] H. Adams,et al. Use of antithrombotic drugs in the treatment of acute ischemic stroke , 1989, Neurology.

[2] J. Broderick,et al. Urgent Therapy for Stroke: Part I. Pilot Study of Tissue Plasminogen Activator Administered Within 90 Minutes , 1992, Stroke.

[3] Detection of Early Axonal Degeneration in the Mammalian Central Nervous System by Magnetization Transfer Techniques in Magnetic Resonance Imaging a , 1993, Annals of the New York Academy of Sciences.

[4] R S Balaban,et al. Magnetization transfer contrast in magnetic resonance imaging. , 1992, Magnetic resonance quarterly.

[5] J. Hajnal,et al. Design and implementation of magnetization transfer pulse sequences for clinical use. , 1992, Journal of computer assisted tomography.

[6] K. Kochanek,et al. Advance report of final mortality statistics, 1991 , 1995 .

[7] C. Anderson,et al. Determining the incidence of different subtypes of stroke: results from the Perth Community Stroke Study, 1989–1990 , 1993, The Medical journal of Australia.

[8] David Lee Gordon,et al. Classification of Subtype of Acute Ischemic Stroke: Definitions for Use in a Multicenter Clinical Trial , 1993, Stroke.

[9] R S Balaban,et al. Magnetization transfer contrast: method for improving contrast in gradient-recalled-echo images. , 1991, Radiology.

[10] D. M. Rosen. New directions for acute stroke therapy , 1993, The Medical journal of Australia.