AN1284 attenuates steatosis, lipogenesis, and fibrosis in mice with pre-existing non-alcoholic steatohepatitis and directly affects aryl hydrocarbon receptor in a hepatic cell line
暂无分享,去创建一个
[1] J. Friedman,et al. Role of Hepatic Aryl Hydrocarbon Receptor in Non-Alcoholic Fatty Liver Disease , 2023, Receptors.
[2] W. Xie,et al. Atypical functions of xenobiotic receptors in lipid and glucose metabolism , 2022, Medical review.
[3] J. Friedman,et al. Cinnabarinic Acid Provides Hepatoprotection Against Nonalcoholic Fatty Liver Disease , 2022, The Journal of Pharmacology and Experimental Therapeutics.
[4] H. Tilg,et al. Current therapies and new developments in NASH , 2022, Gut.
[5] F. Tacke,et al. Nuclear Receptors Linking Metabolism, Inflammation, and Fibrosis in Nonalcoholic Fatty Liver Disease , 2022, International journal of molecular sciences.
[6] J Zhang,et al. Role of the Aryl Hydrocarbon Receptor and Gut Microbiota-Derived Metabolites Indole-3-Acetic Acid in Sulforaphane Alleviates Hepatic Steatosis in Mice , 2021, Frontiers in Nutrition.
[7] A. Carambia,et al. The aryl hydrocarbon receptor in liver inflammation , 2021, Seminars in Immunopathology.
[8] A. Nudelman,et al. Comparison of the tissue distribution and metabolism of AN1284, a potent anti-inflammatory agent, after subcutaneous and oral administration in mice , 2021, Naunyn-Schmiedeberg's Archives of Pharmacology.
[9] A. Moschetta,et al. Transcriptional Regulation of Metabolic Pathways via Lipid-Sensing Nuclear Receptors PPARs, FXR, and LXR in NASH , 2021, Cellular and molecular gastroenterology and hepatology.
[10] F. Tacke,et al. Hepatic macrophages in liver homeostasis and diseases-diversity, plasticity and therapeutic opportunities , 2020, Cellular & molecular immunology.
[11] S. Della Torre. Non-alcoholic Fatty Liver Disease as a Canonical Example of Metabolic Inflammatory-Based Liver Disease Showing a Sex-Specific Prevalence: Relevance of Estrogen Signaling , 2020, Frontiers in Endocrinology.
[12] P. Rada,et al. Understanding lipotoxicity in NAFLD pathogenesis: is CD36 a key driver? , 2020, Cell Death & Disease.
[13] M. Weitman,et al. A Novel Indoline Derivative Ameliorates Diabesity-Induced Chronic Kidney Disease by Reducing Metabolic Abnormalities , 2020, Frontiers in Endocrinology.
[14] S. Romero-Zerbo,et al. The Atypical Cannabinoid Abn-CBD Reduces Inflammation and Protects Liver, Pancreas, and Adipose Tissue in a Mouse Model of Prediabetes and Non-alcoholic Fatty Liver Disease , 2020, Frontiers in Endocrinology.
[15] Shuyu Li,et al. Myricetin Modulates Macrophage Polarization and Mitigates Liver Inflammation and Fibrosis in a Murine Model of Nonalcoholic Steatohepatitis , 2020, Frontiers in Medicine.
[16] R. DeFronzo,et al. GS-0976 (Firsocostat): an investigational liver-directed acetyl-CoA carboxylase (ACC) inhibitor for the treatment of non-alcoholic steatohepatitis (NASH) , 2020, Expert opinion on investigational drugs.
[17] T. Vanhaecke,et al. Anti-NASH Drug Development Hitches a Lift on PPAR Agonism , 2019, Cells.
[18] D. Calvisi,et al. Pathogenetic, Prognostic, and Therapeutic Role of Fatty Acid Synthase in Human Hepatocellular Carcinoma , 2019, Front. Oncol..
[19] G. Carpino,et al. Increased Liver Localization of Lipopolysaccharides in Human and Experimental NAFLD , 2019, Hepatology.
[20] F. Nigsch,et al. Farnesoid X Receptor Agonism, Acetyl‐Coenzyme A Carboxylase Inhibition, and Back Translation of Clinically Observed Endpoints of De Novo Lipogenesis in a Murine NASH Model , 2019, Hepatology communications.
[21] U. Kaul,et al. New dual peroxisome proliferator activated receptor agonist—Saroglitazar in diabetic dyslipidemia and non-alcoholic fatty liver disease: integrated analysis of the real world evidence , 2019, Cardiovascular Diabetology.
[22] R. Schwabe,et al. Aryl Hydrocarbon Receptor Signaling Prevents Activation of Hepatic Stellate Cells and Liver Fibrogenesis in Mice. , 2019, Gastroenterology.
[23] D. Schuppan,et al. Mouse Models of Nonalcoholic Steatohepatitis: Toward Optimization of Their Relevance to Human Nonalcoholic Steatohepatitis , 2019, Hepatology.
[24] V. Dirsch,et al. Natural products as modulators of the nuclear receptors and metabolic sensors LXR, FXR and RXR. , 2018, Biotechnology advances.
[25] Xiangdong Gao,et al. A long‐acting FGF21 alleviates hepatic steatosis and inflammation in a mouse model of non‐alcoholic steatohepatitis partly through an FGF21‐adiponectin‐IL17A pathway , 2018, British journal of pharmacology.
[26] A. Nudelman,et al. Synthesis and Biological Evaluation of Derivatives of Indoline as Highly Potent Antioxidant and Anti-inflammatory Agents. , 2018, Journal of medicinal chemistry.
[27] B. Aronow,et al. Peroxisomal β-oxidation regulates whole body metabolism, inflammatory vigor, and pathogenesis of nonalcoholic fatty liver disease. , 2018, JCI insight.
[28] Gianluca Svegliati-Baroni,et al. Lipotoxicity and the gut-liver axis in NASH pathogenesis. , 2018, Journal of hepatology.
[29] F. Quintana,et al. Regulation of the Immune Response by the Aryl Hydrocarbon Receptor. , 2018, Immunity.
[30] M. Delgado-Rodríguez,et al. Systematic review and meta-analysis. , 2017, Medicina intensiva.
[31] M. Weinstock,et al. Indoline derivatives mitigate liver damage in a mouse model of acute liver injury , 2017, Pharmacological reports : PR.
[32] V. Wong,et al. Increased risk of mortality by fibrosis stage in nonalcoholic fatty liver disease: Systematic review and meta‐analysis , 2017, Hepatology.
[33] E. Levy,et al. Oxidative Stress as a Critical Factor in Nonalcoholic Fatty Liver Disease Pathogenesis. , 2017, Antioxidants & redox signaling.
[34] E. Park,et al. (S)YS-51, a novel isoquinoline alkaloid, attenuates obesity-associated non-alcoholic fatty liver disease in mice by suppressing lipogenesis, inflammation and coagulation. , 2016, European journal of pharmacology.
[35] Hongliang Li,et al. Targeting hepatic TRAF1-ASK1 signaling to improve inflammation, insulin resistance, and hepatic steatosis. , 2016, Journal of hepatology.
[36] Krishnamurthy V. Nemani,et al. Inhibition of the aryl hydrocarbon receptor prevents Western diet-induced obesity. Model for AHR activation by kynurenine via oxidized-LDL, TLR2/4, TGFβ, and IDO1. , 2016, Toxicology and applied pharmacology.
[37] L. Desai,et al. Reciprocal regulation of TGF-β and reactive oxygen species: A perverse cycle for fibrosis , 2015, Redox biology.
[38] Patrice D. Cani,et al. Crosstalk between Gut Microbiota and Dietary Lipids Aggravates WAT Inflammation through TLR Signaling , 2015, Cell metabolism.
[39] Hideji Nakamura,et al. Liver fibrosis markers of nonalcoholic steatohepatitis. , 2015, World journal of gastroenterology.
[40] Xiaochao Ma,et al. Activation of aryl hydrocarbon receptor dissociates fatty liver from insulin resistance by inducing fibroblast growth factor 21 , 2015, Hepatology.
[41] A. Nudelman,et al. Synthesis and in vitro evaluation of anti-inflammatory activity of ester and amine derivatives of indoline in RAW 264.7 and peritoneal macrophages. , 2014, Bioorganic & medicinal chemistry letters.
[42] Fabian Kiessling,et al. CCL2-dependent infiltrating macrophages promote angiogenesis in progressive liver fibrosis , 2014, Gut.
[43] T. Kishimoto,et al. The roles of aryl hydrocarbon receptor in immune responses. , 2013, International immunology.
[44] K. Kang,et al. The inhibitory effect of genistein on hepatic steatosis is linked to visceral adipocyte metabolism in mice with diet-induced non-alcoholic fatty liver disease. , 2010, The British journal of nutrition.
[45] Hang Sun,et al. Effects of nuclear receptor FXR on the regulation of liver lipid metabolism in patients with non-alcoholic fatty liver disease , 2010, Hepatology international.
[46] G. Kristiansen,et al. Expression of fatty acid synthase in nonalcoholic fatty liver disease. , 2010, International journal of clinical and experimental pathology.
[47] J. Folch,et al. A simple method for the isolation and purification of total lipides from animal tissues. , 1957, The Journal of biological chemistry.