A method and system to simulate human electrophysiological activity.

Accurate electrophysiological diagnosis relies on high precision and well calibrated instruments. A method to simulate the human electrophysiological activity is proposed and a simulation system is developed, as a calibration tool for electrophysiological inspectors. The system performance is tested by calibrating the amplitude and the latency of a commercial visual electrophysiological instrument. Several typical simulating signals are tested. The minimum amplitude of the simulating signal can be lower than 1 μV. Measurement errors and uncertainties are calculated. The traceability of the measurement results to metrological standards is also demonstrated. It is proved by experimental results that the system can generate simulating signals with different waveforms and variable parameters and it can be used to simulate the human visual electrophysiological activities. With simple modifications to the simulation system, it can also be used to calibrate other electrophysiological inspectors.

[1]  Michael Bach,et al.  ISCEV standard for clinical visual evoked potentials: (2016 update) , 2016, Documenta Ophthalmologica.

[2]  Rebecca L. Robinson,et al.  Reproducibility Of Visual Electrophysiology Recordings Between Laboratories: The Importance Of Regular Calibration , 2012 .

[3]  S. Graham,et al.  Electrophysiology: a review of signal origins and applications to investigating glaucoma. , 1998, Australian and New Zealand journal of ophthalmology.

[4]  J. Brecelj.  Visual electrophysiology in the clinical evaluation of optic neuritis, chiasmal tumours, achiasmia, and ocular albinism: an overview , 2014, Documenta Ophthalmologica.

[5]  H. Kudrimoti,et al.  Reproducibility of Intraoperative Visual Evoked Potentials: A Review of 141 Cases Undergoing Prone Spinal Procedures , 2010 .

[6]  Michael Bach,et al.  ISCEV standard for clinical visual evoked potentials (2009 update) , 2010, Documenta Ophthalmologica.

[7]  S L Graham,et al.  Electrophysiology: a review of signal origins and applications to investigating glaucoma. , 1998, Australian and New Zealand journal of ophthalmology.

[8]  Michael Bach,et al.  ISCEV standard for clinical pattern electroretinography—2007 update , 2007, Documenta Ophthalmologica.

[9]  Michael Bach,et al.  ISCEV Standard for full-field clinical electroretinography (2015 update) , 2014, Documenta Ophthalmologica.

[10]  Vaegan,et al.  ISCEV Standard for Clinical Electro-oculography (EOG) 2006 , 2006, Documenta Ophthalmologica.

[11]  Michael Bach,et al.  Guidelines for calibration of stimulus and recording parameters used in clinical electrophysiology of vision , 2004, Documenta Ophthalmologica.

[12]  I. Bodis-Wollner.  Visual Electrophysiology in Parkinson's Disease: PERG, VEP and Visual P300 , 1997, Clinical EEG.

[13]  Jagmeet P. Singh,et al.  Advances in Clinical Electrophysiology: 2015 in Review. , 2016, JACC. Clinical electrophysiology.

[14]  T. Hung,et al.  Pattern reversal visual evoked potentials in normal subjects and patients with multiple sclerosis. , 1982, Taiwan yi xue hui za zhi. Journal of the Formosan Medical Association.