TOWARDS FURTHER PENETRATION OF ESD TECHNIQUES – WHAT IS THE ROLE OF JAPANESE ESD EXPERTS ?

The early diagnosis of early gastrointestinal (GI) diseases is becoming easier than ever before, due to the rapid development of all kinds of endoscopic techniques, including chromoendoscopy, narrowband imaging, magnifying endoscopy, confocal microscopy and autofluorescence imaging. Endoscopic resection is gradually becoming the optimal choice, which is significantly less invasive than conventional surgical interventions. In China, endoscopic resection techniques have been developed very quickly after several pioneers learned from Japanese gastroenterologists. Endoscopic submucosal dissection (ESD) has achieved remarkable initial outcomes, however, large-scale, multicenter, retrospective studies of the long-term follow up of ESD outcomes in China are still lacking. New endoscopic interventions are also being developed from the ESD technique, namely, endoscopic full-thickness resection of gastric submucosal tumors, peroral endoscopic myotomy and submucosal tunneling endoscopic resection techniques. Here, we discuss the current status of endoscopic resection in China and several problems: (i) the lack of guideline or consensus from academic society; (ii) approximately half of the ESD are performed on benign submucosal tumors, so the diagnosis of mucosal cancers needs to be increased; (iii) the standard technique used, results, management of complications and follow-up should be standardized; and (iv) the minimum training requirements, the step-by-step approach should also need to be standardized.

[1]  Wei-feng Chen,et al.  Endoscopic full-thickness resection without laparoscopic assistance for gastric submucosal tumors originated from the muscularis propria , 2011, Surgical Endoscopy.

[2]  S. Kudo,et al.  Peroral endoscopic myotomy (POEM) for esophageal achalasia* , 2010, Endoscopy.

[3]  T. Gotoda,et al.  Remarkable progress in endoscopic resection of early gastric cancer , 2009, Journal of gastroenterology and hepatology.

[4]  L. Yao,et al.  Endoscopic submucosal dissection for colorectal epithelial neoplasm , 2009, Surgical Endoscopy.

[5]  Wei-feng Chen,et al.  Endoscopic submucosal dissection for rectal lesions , 2007 .

[6]  Ayako Tateishi,et al.  Successful outcomes of a novel endoscopic treatment for GI tumors: endoscopic submucosal dissection with a mixture of high-molecular-weight hyaluronic acid, glycerin, and sugar. , 2006, Gastrointestinal endoscopy.

[7]  T. Nakajima Gastric cancer treatment guidelines in Japan , 2002, Gastric Cancer.

[8]  S. Yoshida,et al.  Endoscopic mucosal resection for treatment of early gastric cancer , 2001, Gut.

[9]  Y. Nakanishi,et al.  Incidence of lymph node metastasis from early gastric cancer: estimation with a large number of cases at two large centers , 2000, Gastric Cancer.

[10]  A. Munakata,et al.  Endoscopic mucosal resection of gastric neoplasms using a ligating device. , 1997, Gastrointestinal endoscopy.

[11]  H. Inoue,et al.  A new simplified technique of endoscopic esophageal mucosal resection using a cap-fitted panendoscope (EMRC) , 1992, Surgical Endoscopy.

[12]  K. Okita,et al.  Endoscopic therapy for early colon cancer: the strip biopsy resection technique. , 1991, Gastrointestinal endoscopy.

[13]  M. Tada,et al.  [Endoscopic therapy of early gastric cancer by strip biopsy]. , 1988, Gan to kagaku ryoho. Cancer & chemotherapy.

[14]  Wei-feng Chen,et al.  Submucosal tunneling endoscopic resection: a new technique for treating upper GI submucosal tumors originating from the muscularis propria layer (with videos). , 2012, Gastrointestinal endoscopy.

[15]  Z. Ye Effectiveness analysis of endoscopic submucosal dissection on 56 cases of gastrointestinal lesions , 2011 .

[16]  Zhang Dao-quan Endoscopic submucosal dissection for upper gastrointestinal lesions , 2011 .

[17]  H. Inoue,et al.  Endoscopic mucosal resection with a cap-fitted panendoscope for esophagus, stomach, and colon mucosal lesions. , 1993, Gastrointestinal endoscopy.