Anti‐thyroid drugs decrease mucosal damage in a rat model of experimental colitis

Background: Methimazole, an anti‐thyroid drug, was recently found to be useful in the treatment of systemic lupus erythematosus and other autoimmune diseases. Moreover, decreased thyroid hormone production is associated with a variety of immunological manifestations, such as reduced activation of CD4+ cells, increased CD8+ cell activity and reduced soluble IL‐2 receptors. In the present study we examined the effects of methimazole and propylthiouracil on a rat model of experimental colitis.

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