Does GnRH agonist enhance the final adult height in girls with precocious puberty?

Background: Girls with sign of secondary sexual characteristic before the age of 8 years are defined as precocious puberty (PP). Early activation of hypothalamo-pituitary-gonadal axis causes central PP. Without treatment, some become short adult height and early menstruation may develop. Objective: Report the final adult height in precocious puberty girls who have been treated with GnRH agonist. Methods: Seventy girls with PP and early puberty (EP) who were treated with GnRH agonist have been followed up until they reach final height (FH). FH was compared with predicted adult height (PAH) before treatment and mid-parental height (MPH). Results: All subjects were treated with GnRH agonist for a mean duration of 1.9 0.6 years. FH was significantly higher than PAH before treatment (156.6±5.1 vs. 151.6±6 cm, p <0.001). FH is positively correlated with MPH. However, treatment with GnRH agonist in EP girls and in PP girls with bone age of more than 12.5 years or those who already had menstruation may have less benefit. Conclusion: GnRH agonist can enhance FH in girls with PP. Early treatment in those with bone age of less than 12.5 years or before menstruation may result in good outcome.

[1]  S. Wacharasindhu,et al.  Pubertal growth in normal Thai children: a longitudinal study , 2010 .

[2]  S. Cesario,et al.  Precocious puberty: a comprehensive review of literature. , 2007, Journal of obstetric, gynecologic, and neonatal nursing : JOGNN.

[3]  M. Phillip,et al.  Gonadotropin-suppressive therapy in girls with early and fast puberty affects the pace of puberty but not total pubertal growth or final height. , 2002, The Journal of clinical endocrinology and metabolism.

[4]  K. Klein,et al.  Increased final height in precocious puberty after long-term treatment with LHRH agonists: the National Institutes of Health experience. , 2001, The Journal of clinical endocrinology and metabolism.

[5]  A. Rogol.  Early menarche and adult height: reprise of the hare and the tortoise? , 2001, The Journal of pediatrics.

[6]  E. Obarzanek,et al.  Impact of timing of pubertal maturation on growth in black and white female adolescents: The National Heart, Lung, and Blood Institute Growth and Health Study. , 2001, The Journal of pediatrics.

[7]  J. Coste,et al.  Lack of effect of GnRH agonists on final height in girls with advanced puberty: a randomized long-term pilot study. , 1999, The Journal of clinical endocrinology and metabolism.

[8]  A. Balsamo,et al.  Randomised trial of LHRH analogue treatment on final height in girls with onset of puberty aged 7.5–8.5 years , 1999, Archives of disease in childhood.

[9]  A. Pasquino,et al.  Analysis of the factors affecting auxological response to GnRH agonist treatment and final height outcome in girls with idiopathic central precocious puberty. , 1999, European journal of endocrinology.

[10]  J. Carel,et al.  Final height after long-term treatment with triptorelin slow release for central precocious puberty: importance of statural growth after interruption of treatment. French study group of Decapeptyl in Precocious Puberty. , 1999, The Journal of clinical endocrinology and metabolism.

[11]  Z. Laron,et al.  Final height of girls with central precocious puberty, untreated versus treated with cyproterone acetate or GnRH analogue. A comparative study with re-evaluation of predictions by the Bayley-Pinneau method. , 1997, Hormone research.

[12]  P. Saenger,et al.  Bayley-Pinneau method of height prediction in girls with central precocious puberty: correlation with adult height. , 1995, The Journal of pediatrics.

[13]  S. Bernasconi,et al.  Final height in girls with central precocious puberty: comparison of two different luteinizing hormone‐releasing hormone agonist treatments , 1994, Acta paediatrica.

[14]  G. Kletter,et al.  Clinical review 60: Effects of gonadotropin-releasing hormone analog therapy on adult stature in precocious puberty. , 1994, The Journal of clinical endocrinology and metabolism.

[15]  P. Hindmarsh,et al.  Sexual precocity: sex incidence and aetiology. , 1994, Archives of Disease in Childhood.

[16]  J M Tanner,et al.  Standards for Children's Height at Ages 2-9 Years Allowing for Height of Parents , 1970, Archives of disease in childhood.

[17]  N. Bayley,et al.  Tables for predicting adult height from skeletal age: revised for use with the Greulich-Pyle hand standards. , 1952, The Journal of pediatrics.

[18]  H. Vignes.  [Precocious puberty]. , 1950, Journal des praticiens; revue generale de clinique et de therapeutique.