Circumcision and sexually transmitted diseases.

OBJECTIVES New evidence linking lack of circumcision with sexually transmitted human immunodeficiency virus revives concerns about circumcision and other sexually transmitted diseases. This study was undertaken to assess the relationship between circumcision and syphilis, gonorrhea, chlamydial infection, genital herpes, nongonococcal urethritis, and exophytic genital warts. METHODS A cross-sectional study of 2776 heterosexual men attending a sexually transmitted disease clinic in 1988 was used to investigate the relationship between circumcision and sexually transmitted diseases. Subjects with specific sexually transmitted diseases and those without such diseases were compared after adjustment for age, race, zip code of residence, other sexually transmitted diseases, and number of sexual partners. RESULTS A positive relationship was observed between uncircumcised status and both syphilis and gonorrhea. A negative relationship was found between warts and lack of circumcision. No apparent relationship was noted between uncircumcised status and genital herpes, chlamydial infection, or nongonococcal urethritis. CONCLUSIONS Uncircumcised men were more likely than circumcised men to have syphilis and gonorrhea and were less likely to have visible warts.

[1]  N. Jewell,et al.  Female-to-male transmission of human immunodeficiency virus. , 1992, JAMA.

[2]  W. Te.  Routine neonatal circumcision: a reappraisal. , 1990 .

[3]  P. Perine,et al.  Genital ulcers and male circumcision as risk factors for acquiring HIV-1 in Zambia. , 1990, The Journal of infectious diseases.

[4]  T. Wiswell.  Routine neonatal circumcision: a reappraisal. , 1990, American family physician.

[5]  P. Piot,et al.  Human immunodeficiency virus infection among men with sexually transmitted diseases. Experience from a center in Africa. , 1988, The New England journal of medicine.

[6]  R. Greenup,et al.  Circumcision as a risk factor for urethritis in racial groups. , 1987, American journal of public health.

[7]  A. Ling,et al.  The management of purulent penile ulcers in Singapore. , 1986, Singapore medical journal.

[8]  A. Ling,et al.  Purulent penile ulcers of patients in Singapore. , 1986, Genitourinary medicine.

[9]  M. H. Ross,et al.  Histology: A Text and Atlas , 1985 .

[10]  Stewart Aj,et al.  Circumcision and sexually transmissible disease. , 1983 .

[11]  J. Straton,et al.  Circumcision and sexually transmissible disease , 1983, The Medical journal of Australia.

[12]  N. Breslow,et al.  Statistical methods in cancer research: volume 1- The analysis of case-control studies , 1980 .

[13]  N. Breslow,et al.  The analysis of case-control studies , 1980 .

[14]  N Breslow,et al.  Are there two logistic regressions for retrospective studies? , 1978, Biometrics.

[15]  P K Taylor,et al.  Herpes genitalis and circumcision. , 1975, The British journal of venereal diseases.

[16]  R. Wilson.  Circumcision and venereal disease. , 1947, Canadian Medical Association journal.