Injury-induced immune responses in Hydra.

[1]  S. Weng,et al.  Nucleic acid-induced antiviral immunity in invertebrates: an evolutionary perspective. , 2015, Developmental and comparative immunology.

[2]  P. Lőw,et al.  The Role of the Selective Adaptor p62 and Ubiquitin-Like Proteins in Autophagy , 2014, BioMed research international.

[3]  P. Greer,et al.  Calpains promote neutrophil recruitment and bacterial clearance in an acute bacterial peritonitis model , 2014, European journal of immunology.

[4]  M. Narasimha,et al.  Mitochondrial ROS regulates cytoskeletal and mitochondrial remodeling to tune cell and tissue dynamics in a model for wound healing. , 2014, Developmental cell.

[5]  K. Clark.  Protein kinase networks that limit TLR signalling. , 2014, Biochemical Society transactions.

[6]  P. Mandrekar,et al.  Cellular stress response and innate immune signaling: integrating pathways in host defense and inflammation , 2013, Journal of leukocyte biology.

[7]  D. Richter,et al.  The genomic and cellular foundations of animal origins. , 2013, Annual review of genetics.

[8]  J. Bayes,et al.  The Characterization of Sponge NLRs Provides Insight into the Origin and Evolution of This Innate Immune Gene Family in Animals , 2013, Molecular biology and evolution.

[9]  Y. Wenger,et al.  Punctuated Emergences of Genetic and Phenotypic Innovations in Eumetazoan, Bilaterian, Euteleostome, and Hominidae Ancestors , 2013, Genome biology and evolution.

[10]  David H Perlman,et al.  Calpain A modulates Toll responses by limited Cactus/IκB proteolysis , 2013, Molecular biology of the cell.

[11]  T. Bosch.  Cnidarian-microbe interactions and the origin of innate immunity in metazoans. , 2013, Annual review of microbiology.

[12]  Jun Wang,et al.  Distinct antimicrobial peptide expression determines host species-specific bacterial associations , 2013, Proceedings of the National Academy of Sciences.

[13]  Mohamed Bouzaffour,et al.  Sustained production of ROS triggers compensatory proliferation and is required for regeneration to proceed , 2013, Scientific Reports.

[14]  Shing-Jyh Chang,et al.  Treatment of Glucocorticoids Inhibited Early Immune Responses and Impaired Cardiac Repair in Adult Zebrafish , 2013, PloS one.

[15]  C. Colaco,et al.  Heat Shock Proteins: Stimulators of Innate and Acquired Immunity , 2013, BioMed research international.

[16]  N. Rosenthal,et al.  Macrophages are required for adult salamander limb regeneration , 2013, Proceedings of the National Academy of Sciences.

[17]  M. Newman,et al.  MAMP (microbe-associated molecular pattern) triggered immunity in plants , 2013, Front. Plant Sci..

[18]  Y. Wenger,et al.  RNAseq versus genome-predicted transcriptomes: a large population of novel transcripts identified in an Illumina-454 Hydra transcriptome , 2013, BMC Genomics.

[19]  J. Cordeiro,et al.  The role of transcription-independent damage signals in the initiation of epithelial wound healing , 2013, Nature Reviews Molecular Cell Biology.

[20]  E. Amaya,et al.  Amputation-induced reactive oxygen species (ROS) are required for successful Xenopus tadpole tail regeneration , 2013, Nature Cell Biology.

[21]  T. Natsume,et al.  The Kelch repeat protein KLHDC10 regulates oxidative stress-induced ASK1 activation by suppressing PP5. , 2012, Molecular cell.

[22]  S. V. Nyholm,et al.  Knowing your friends: invertebrate innate immunity fosters beneficial bacterial symbioses , 2012, Nature Reviews Microbiology.

[23]  S. Künzel,et al.  MyD88-deficient Hydra reveal an ancient function of TLR signaling in sensing bacterial colonizers , 2012, Proceedings of the National Academy of Sciences.

[24]  J. Clardy,et al.  A bacterial sulfonolipid triggers multicellular development in the closest living relatives of animals , 2012, eLife.

[25]  H. Sorg,et al.  Wound Repair and Regeneration , 2012, European Surgical Research.

[26]  B. Willis,et al.  Expression of Putative Immune Response Genes during Early Ontogeny in the Coral Acropora millepora , 2012, PloS one.

[27]  Patrick G. A. Pedrioli,et al.  The IkappaB Kinase Family Phosphorylates the Parkinson’s Disease Kinase LRRK2 at Ser935 and Ser910 during Toll-Like Receptor Signaling , 2012, PloS one.

[28]  Marco Crescenzi,et al.  Hydra, a versatile model to study the homeostatic and developmental functions of cell death. , 2012, The International journal of developmental biology.

[29]  M. Sarras.  Components, structure, biogenesis and function of the Hydra extracellular matrix in regeneration, pattern formation and cell differentiation. , 2012, The International journal of developmental biology.

[30]  Simon C Watkins,et al.  The apoptotic engulfment protein Ced-6 participates in clathrin-mediated yolk uptake in Drosophila egg chambers , 2012, Molecular biology of the cell.

[31]  P. Ray,et al.  Reactive oxygen species (ROS) homeostasis and redox regulation in cellular signaling. , 2012, Cellular signalling.

[32]  T. Kawasaki,et al.  Function of Arabidopsis SWAP70 GEF in immune response , 2012, Plant signaling & behavior.

[33]  V. Dixit,et al.  Signaling in innate immunity and inflammation. , 2012, Cold Spring Harbor perspectives in biology.

[34]  H. Cai,et al.  Loss of leucine-rich repeat kinase 2 causes age-dependent bi-phasic alterations of the autophagy pathway , 2012, Molecular Neurodegeneration.

[35]  Zhong-Ping Feng,et al.  Identification of the role of C/EBP in neurite regeneration following microarray analysis of a L. stagnalis CNS injury model , 2012, BMC Neuroscience.

[36]  N. Paricio,et al.  Drosophila as a model of wound healing and tissue regeneration in vertebrates , 2011, Developmental dynamics : an official publication of the American Association of Anatomists.

[37]  Pablo C. Echeverría,et al.  An Interaction Network Predicted from Public Data as a Discovery Tool: Application to the Hsp90 Molecular Chaperone Machine , 2011, PloS one.

[38]  Paul Martin,et al.  Swatting flies: modelling wound healing and inflammation in Drosophila , 2011, Disease Models & Mechanisms.

[39]  C. Wiessner,et al.  Regulation of LRRK2 Expression Points to a Functional Role in Human Monocyte Maturation , 2011, PloS one.

[40]  Ulrich C. Klostermeier,et al.  Defining the origins of the NOD-like receptor system at the base of animal evolution. , 2011, Molecular biology and evolution.

[41]  Junichi Tsukada,et al.  The CCAAT/enhancer (C/EBP) family of basic-leucine zipper (bZIP) transcription factors is a multifaceted highly-regulated system for gene regulation. , 2011, Cytokine.

[42]  B Franz Lang,et al.  Unexpected repertoire of metazoan transcription factors in the unicellular holozoan Capsaspora owczarzaki. , 2011, Molecular biology and evolution.

[43]  Y. Wenger,et al.  Injury‐induced activation of the MAPK/CREB pathway triggers apoptosis‐induced compensatory proliferation in hydra head regeneration , 2011, Development, growth & differentiation.

[44]  Rafael D. Rosengarten,et al.  Model Systems of Invertebrate Allorecognition , 2011, Current Biology.

[45]  S. Srinivasula,et al.  Nrf2-mediated induction of p62 controls Toll-like receptor-4–driven aggresome-like induced structure formation and autophagic degradation , 2011, Proceedings of the National Academy of Sciences.

[46]  Mark J Daly,et al.  LRRK2 Is Involved in the IFN-γ Response and Host Response to Pathogens , 2010, The Journal of Immunology.

[47]  Thomas C G Bosch,et al.  In an early branching metazoan, bacterial colonization of the embryo is controlled by maternal antimicrobial peptides , 2010, Proceedings of the National Academy of Sciences.

[48]  S. Kawabata,et al.  Proteolytic cascades and their involvement in invertebrate immunity. , 2010, Trends in biochemical sciences.

[49]  B. Degnan,et al.  The genome of the sponge Amphimedon queenslandica provides new perspectives into the origin of Toll‐like and interleukin 1 receptor pathways , 2010, Evolution & development.

[50]  Todd H. Oakley,et al.  The Amphimedon queenslandica genome and the evolution of animal complexity , 2010, Nature.

[51]  R. Xavier,et al.  Human leucine-rich repeat proteins: a genome-wide bioinformatic categorization and functional analysis in innate immunity , 2010, Proceedings of the National Academy of Sciences.

[52]  Rafael D. Rosengarten,et al.  Hydractinia Allodeterminant alr1 Resides in an Immunoglobulin Superfamily-like Gene Complex , 2010, Current Biology.

[53]  Jiahuai Han,et al.  Receptor-interacting protein (RIP) kinase family , 2010, Cellular and Molecular Immunology.

[54]  G. Sykiotis,et al.  Stress-Activated Cap'n'collar Transcription Factors in Aging and Human Disease , 2010, Science Signaling.

[55]  Paul Martin,et al.  Prioritization of Competing Damage and Developmental Signals by Migrating Macrophages in the Drosophila Embryo , 2010, Current Biology.

[56]  Katherine M. Buckley,et al.  Highly diversified innate receptor systems and new forms of animal immunity. , 2010, Seminars in immunology.

[57]  T. Bosch,et al.  How Hydra senses and destroys microbes. , 2010, Seminars in immunology.

[58]  R. Hrdličková,et al.  Dynamic evolution of immune system regulators: the history of the interferon regulatory factor family. , 2009, Molecular biology and evolution.

[59]  Nichole A. Broderick,et al.  Invasive and indigenous microbiota impact intestinal stem cell activity through multiple pathways in Drosophila. , 2009, Genes & development.

[60]  T. Bosch,et al.  Activity of the Novel Peptide Arminin against Multiresistant Human Pathogens Shows the Considerable Potential of Phylogenetically Ancient Organisms as Drug Sources , 2009, Antimicrobial Agents and Chemotherapy.

[61]  J. Martinou,et al.  Apoptotic cells provide an unexpected source of Wnt3 signaling to drive hydra head regeneration. , 2009, Developmental cell.

[62]  T. Kubo,et al.  Suppression of the immune response potentiates tadpole tail regeneration during the refractory period , 2009, Development.

[63]  T. Krieg,et al.  Interrelation of immunity and tissue repair or regeneration. , 2009, Seminars in cell & developmental biology.

[64]  Timothy J. Mitchison,et al.  A tissue-scale gradient of hydrogen peroxide mediates rapid wound detection in zebrafish , 2009, Nature.

[65]  Shizuo Akira,et al.  The roles of TLRs, RLRs and NLRs in pathogen recognition. , 2009, International immunology.

[66]  Philip Rosenstiel,et al.  Uncovering the evolutionary history of innate immunity: the simple metazoan Hydra uses epithelial cells for host defence. , 2009, Developmental and comparative immunology.

[67]  M. Komatsu,et al.  A role for NBR1 in autophagosomal degradation of ubiquitinated substrates. , 2009, Molecular cell.

[68]  G. Núñez,et al.  NOD-like receptors: role in innate immunity and inflammatory disease. , 2009, Annual review of pathology.

[69]  Osamu Nakamura,et al.  The function of rhamnose-binding lectin in innate immunity by restricted binding to Gb3. , 2009, Developmental and comparative immunology.

[70]  H. Aburatani,et al.  Nrf1 and Nrf2 Play Distinct Roles in Activation of Antioxidant Response Element-dependent Genes* , 2008, Journal of Biological Chemistry.

[71]  M. Leippe,et al.  Hydramacin-1, Structure and Antibacterial Activity of a Protein from the Basal Metazoan Hydra* , 2008, Journal of Biological Chemistry.

[72]  M. Kimura.  IRF2‐binding protein‐1 is a JDP2 ubiquitin ligase and an inhibitor of ATF2‐dependent transcription , 2008, FEBS letters.

[73]  Xinglong Wang,et al.  The Roc domain of leucine‐rich repeat kinase 2 is sufficient for interaction with microtubules , 2008, Journal of neuroscience research.

[74]  B. Altincicek,et al.  Comparative analysis of septic injury-inducible genes in phylogenetically distant model organisms of regeneration and stem cell research, the planarian Schmidtea mediterranea and the cnidarian Hydra vulgaris , 2008, Frontiers in Zoology.

[75]  B. Degnan,et al.  The transcription factor NF-κB in the demosponge Amphimedon queenslandica: insights on the evolutionary origin of the Rel homology domain , 2008, Development Genes and Evolution.

[76]  Robert L. Tanguay,et al.  Unraveling Tissue Regeneration Pathways Using Chemical Genetics* , 2007, Journal of Biological Chemistry.

[77]  J. Keefer,et al.  C/EBPα:AP-1 leucine zipper heterodimers bind novel DNA elements, activate the PU.1 promoter and direct monocyte lineage commitment more potently than C/EBPα homodimers or AP-1 , 2007, Oncogene.

[78]  T. Bosch,et al.  Transgenic Stem Cells in Hydra Reveal an Early Evolutionary Origin for Key Elements Controlling Self-renewal and Differentiation , 2007 .

[79]  N. Borregaard,et al.  Neutrophil granules: a library of innate immunity proteins. , 2007, Trends in immunology.

[80]  David J. Miller,et al.  The innate immune repertoire in Cnidaria - ancestral complexity and stochastic gene loss , 2007, Genome Biology.

[81]  W. Müller,et al.  Toll-like receptors are part of the innate immune defense system of sponges (demospongiae: Porifera). , 2006, Molecular biology and evolution.

[82]  Jonathan D. G. Jones,et al.  The plant immune system , 2006, Nature.

[83]  J. Brockes,et al.  Regeneration, tissue injury and the immune response , 2006, Journal of anatomy.

[84]  J. McCubrey,et al.  Reactive oxygen species-induced activation of the MAP kinase signaling pathways. , 2006, Antioxidants & redox signaling.

[85]  S. Pervaiz,et al.  TNF receptor superfamily‐induced cell death: redox‐dependent execution , 2006, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[86]  R. de Rosa,et al.  Hydra, a niche for cell and developmental plasticity. , 2006, Seminars in cell & developmental biology.

[87]  R. Jessberger,et al.  Signaling protein SWAP-70 is required for efficient B cell homing to lymphoid organs , 2006, Nature Immunology.

[88]  Patrice Koehl,et al.  Plant NBS-LRR proteins: adaptable guards , 2006, Genome Biology.

[89]  R. de Rosa,et al.  Silencing of the hydra serine protease inhibitor Kazal1 gene mimics the human SPINK1 pancreatic phenotype , 2006, Journal of Cell Science.

[90]  Y. Miyachi,et al.  Lymphangiogenesis promotes lens destruction and subsequent lens regeneration in the newt eyeball, and both processes can be accelerated by transplantation of dendritic cells. , 2006, Developmental biology.

[91]  Paul Martin,et al.  Inflammatory cells during wound repair: the good, the bad and the ugly. , 2005, Trends in cell biology.

[92]  Jacob A. Tennessen,et al.  Molecular evolution of animal antimicrobial peptides: widespread moderate positive selection , 2005, Journal of evolutionary biology.

[93]  H. Ushijima,et al.  Innate Immune Defense of the Sponge Suberites domuncula against Bacteria Involves a MyD88-dependent Signaling Pathway , 2005, Journal of Biological Chemistry.

[94]  B. Habermann,et al.  Modulation of Receptor Recycling and Degradation by the Endosomal Kinesin KIF16B , 2005, Cell.

[95]  J. C. Wilkinson,et al.  The Small Heat Shock Protein αB-crystallin Is a Novel Inhibitor of TRAIL-induced Apoptosis That Suppresses the Activation of Caspase-3* , 2005, Journal of Biological Chemistry.

[96]  Michael Karin,et al.  Reactive Oxygen Species Promote TNFα-Induced Death and Sustained JNK Activation by Inhibiting MAP Kinase Phosphatases , 2005, Cell.

[97]  A. Beck‐Sickinger,et al.  Neuropeptide Y and its receptor subtypes specifically modulate rat peritoneal macrophage functions in vitro: counter regulation through Y1 and Y2/5 receptors , 2005, Regulatory Peptides.

[98]  C. Cheng‐Mayer,et al.  Molecular Mechanism of hTid-1, the Human Homolog of Drosophila Tumor Suppressor l(2)Tid, in the Regulation of NF-κB Activity and Suppression of Tumor Growth , 2005, Molecular and Cellular Biology.

[99]  Hiroaki Kitano,et al.  The PANTHER database of protein families, subfamilies, functions and pathways , 2004, Nucleic Acids Res..

[100]  I. Adcock,et al.  Effects of glucocorticoids on gene transcription. , 2004, European journal of pharmacology.

[101]  J. Yates,et al.  The CREB Coactivator TORC2 Functions as a Calcium- and cAMP-Sensitive Coincidence Detector , 2004, Cell.

[102]  Shizuo Akira,et al.  Toll-like receptor signalling , 2004, Nature Reviews Immunology.

[103]  Brian Stramer,et al.  Wound healing and inflammation: embryos reveal the way to perfect repair. , 2004, Philosophical transactions of the Royal Society of London. Series B, Biological sciences.

[104]  B. Galliot,et al.  Reactivation of developmental programs: the cAMP-response element-binding protein pathway is involved in hydra head regeneration. , 2004, Proceedings of the National Academy of Sciences of the United States of America.

[105]  S. Mckercher,et al.  Wound Healing in the PU.1 Null Mouse—Tissue Repair Is Not Dependent on Inflammatory Cells , 2003, Current Biology.

[106]  S. Goodbourn,et al.  Identification of novel co-repressor molecules for Interferon Regulatory Factor-2. , 2003, Nucleic acids research.

[107]  A. Henschen-Edman,et al.  Structural Determinants of Procryptdin Recognition and Cleavage by Matrix Metalloproteinase-7* , 2003, The Journal of Biological Chemistry.

[108]  T. Stephenson,et al.  Expression of proteinases and inhibitors in human breast cancer progression and survival , 2002, Molecular pathology : MP.

[109]  U. Frank,et al.  The ontogeny of allorecognition in a colonial hydroid and the fate of early established chimeras. , 2002, The International journal of developmental biology.

[110]  James Douglas Engel,et al.  Integration and diversity of the regulatory network composed of Maf and CNC families of transcription factors. , 2002, Gene.

[111]  M. Milla,et al.  The tumor necrosis factor-alpha converting enzyme (TACE): a unique metalloproteinase with highly defined substrate selectivity. , 2002, Biochemistry.

[112]  T. Ganz,et al.  Paneth cell trypsin is the processing enzyme for human defensin-5 , 2002, Nature Immunology.

[113]  A. Leontovich,et al.  Epithelial morphogenesis in hydra requires de novo expression of extracellular matrix components and matrix metalloproteinases. , 2002, Development.

[114]  C. Funk,et al.  Prostaglandins and leukotrienes: advances in eicosanoid biology. , 2001, Science.

[115]  I. Adcock,et al.  Glucocorticoid-regulated transcription factors. , 2001, Pulmonary pharmacology & therapeutics.

[116]  M. Peters-Golden,et al.  Leukotriene B4 Augments Neutrophil Phagocytosis of Klebsiella pneumoniae , 2001, Infection and Immunity.

[117]  V. Chau,et al.  Nedd8 Modification of Cul-1 Activates SCFβTrCP-Dependent Ubiquitination of IκBα , 2000, Molecular and Cellular Biology.

[118]  A. Leontovich,et al.  A novel hydra matrix metalloproteinase (HMMP) functions in extracellular matrix degradation, morphogenesis and the maintenance of differentiated cells in the foot process. , 2000, Development.

[119]  W. Müller,et al.  Evolution of the innate and adaptive immune systems: relationships between potential immune molecules in the lowest metazoan phylum (Porifera) and those in vertebrates. , 1999, Transplantation.

[120]  J. Quigley,et al.  Alpha2-macroglobulin: an evolutionarily conserved arm of the innate immune system. , 1999, Developmental and comparative immunology.

[121]  Mister W. Dodds,et al.  The phylogeny and evolution of the thioester bond‐containing proteins C3, C4 and α2–macroglobulin , 1998 .

[122]  Valeria Poli,et al.  The Role of C/EBP Isoforms in the Control of Inflammatory and Native Immunity Functions* , 1998, The Journal of Biological Chemistry.

[123]  M. Hengartner,et al.  Candidate Adaptor Protein CED-6 Promotes the Engulfment of Apoptotic Cells in C. elegans , 1998, Cell.

[124]  Kohei Miyazono,et al.  Mammalian thioredoxin is a direct inhibitor of apoptosis signal‐regulating kinase (ASK) 1 , 1998, The EMBO journal.

[125]  D. Cohen,et al.  Transcriptional regulation in the immune system: all roads lead to AP‐1 , 1998, Journal of leukocyte biology.

[126]  J. Peschon,et al.  Initiation of liver growth by tumor necrosis factor: deficient liver regeneration in mice lacking type I tumor necrosis factor receptor. , 1997, Proceedings of the National Academy of Sciences of the United States of America.

[127]  M. Luster,et al.  Induction of early‐immediate genes by tumor necrosis factor α contribute to liver repair following chemical‐induced hepatotoxicity , 1997, Hepatology.

[128]  D. Brenner,et al.  Tumor necrosis factor-alpha induces c-jun during the regenerative response to liver injury. , 1994, The American journal of physiology.

[129]  L. Petrocellis,et al.  Arachidonic acid, protein kinase C activators and bud formation in Hydra vulgaris , 1993 .

[130]  W. Lehmann,et al.  Arachidonic acid and the control of body pattern inHydra , 1993, Roux's archives of developmental biology.

[131]  R. Grosberg.  The Evolution of Allorecognition Specificity in Clonal Invertebrates , 1988, The Quarterly Review of Biology.

[132]  H. Lenhoff,et al.  Trembley's Polyps , 1988 .

[133]  C. David,et al.  Immunocompetence in Hydra. Epithelial cells recognize self-nonself and react against it , 1986 .

[134]  L. Smith,et al.  Allogeneic cell interactions during graft rejection in Callyspongia diffusa (Porifera, Demospongia); a study with monoclonal antibodies , 1986, Proceedings of the Royal Society of London. Series B. Biological Sciences.

[135]  P. Jokiel,et al.  CYTOTOXIC TRANSPLANTATION IMMUNITY IN THE SPONGE TOXADOCIA VIOLACEA , 1983, Transplantation.

[136]  J. Kagan,et al.  The Dorsoventral Regulatory Gene Cassette spätzle / Toll / cactus Controls the Potent Antifungal Response in Drosophila Adults , 2015 .

[137]  N. Rosenthal,et al.  Scar-free wound healing and regeneration in amphibians: immunological influences on regenerative success. , 2014, Differentiation; research in biological diversity.

[138]  S. Vriz,et al.  Cell death: a program to regenerate. , 2014, Current topics in developmental biology.

[139]  N. Satoh,et al.  The complex NOD-like receptor repertoire of the coral Acropora digitifera includes novel domain combinations. , 2013, Molecular biology and evolution.

[140]  大辻 摩希子.  Nrf1 and Nrf2 play distinct roles in activation of antioxidant response element-dependent genes , 2009 .

[141]  B. Degnan,et al.  Partitioning of genetically distinct cell populations in chimeric juveniles of the sponge Amphimedon queenslandica. , 2008, Developmental and comparative immunology.

[142]  J. Keefer,et al.  C/EBP alpha:AP-1 leucine zipper heterodimers bind novel DNA elements, activate the PU.1 promoter and direct monocyte lineage commitment more potently than C/EBP alpha homodimers or AP-1. , 2008, Oncogene.

[143]  F. Gallyas,et al.  Inhibition of cell death by a novel 16.2 kD heat shock protein predominantly via Hsp90 mediated lipid rafts stabilization and Akt activation pathway , 2006, Apoptosis.

[144]  Raymond J. Deshaies,et al.  Function and regulation of cullin–RING ubiquitin ligases , 2005, Nature Reviews Molecular Cell Biology.

[145]  Soojin Lee,et al.  Mechanisms for regulation of Hsp70 function by Hsp40 , 2003, Cell stress & chaperones.

[146]  V. Chau,et al.  Nedd8 Modification of Cul-1 Activates SCF , 2000 .

[147]  J. Quigley,et al.  Alpha2-macroglobulin: an evolutionarily conserved arm of the innate immune system. , 1999, Developmental and comparative immunology.

[148]  S. Law,et al.  The phylogeny and evolution of the thioester bond-containing proteins C3, C4 and alpha 2-macroglobulin. , 1998, Immunological reviews.

[149]  Elias Metschnikoff.  Leçons sur la pathologie comparée de l'inflammation , 1893 .