The Relationship between Exploratory Eye Movement Dysfunction and Psychiatric Symptoms in Schizophrenia

要旨 統合失調症では,視覚認知に関わる探索眼球運 動 (exploratory eye movement: EEM)の異常が見られ,特 に再認過程に見られる眼球運動パターンは疾患特異的で あることが報告されている.今回,76名の統合失調症 患者に関し,陽性・陰性症状評価尺度を用いた詳細な精 神症状評価を行い,EEMでみられる視覚認知機能異常 がどのような精神症状と関連するか検討した.EEMの 指標としては対象注視時の注視点の総移動距離,再認過 程における EEMの広がりを表す反応的探索スコアを用 い,この成績で対象を 2群に分け精神症状との関連を検 討した.その結果,EEMでの視覚性認知過程の障害は 陽性・陰性症状評価尺度における陰性症状と関連してい ることが明らかになった.EEMは前頭葉において制御 されていることが考えられることから,統合失調症の陰 性症状と前頭葉の機能低下との関連を生理学的側面から 実証したものと考えられた. 原 著

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