BIODEGRADABLE PLGA NANOPARTICLES CONJUGATED TO FOLIC ACID FOR TARGETED DELIVERY OF KAEMPFERITRIN

Kaempferitrin loaded biodegradable poly (D, L lactide-co-glycolide) acid (PLGA) nanoparticles were developed by solvent emulsion evaporation method. Folic acid with the % of PLGA successfully absorbed, and incorporation of drug content was performed for the formulated PLGA-Nps. The synthesized KM+FA+PLGA-Nps were characterized by XRD, FTIR, SEM, and TEM. In vitro cytotoxicity study on HT-29 cell lines using MTT assay, apoptotic study revealed that KM+FA+PLGA-Nps has high cytotoxic effect compared to kaempferitrin drug solution. These results evidenced that KM+FA+PLGA-Nps might be a promising anti-cancer pharmacotherapy for targeted drug delivery in HT-29 colon adenocarcinoma cells.

[1]  G. Alí,et al.  Chemotherapeutic and antiangiogenic drugs beyond tumor progression in colon cancer: Evaluation of the effects of switched schedules and related pharmacodynamics. , 2019, Biochemical pharmacology.

[2]  Dezhong Sun,et al.  Nasopharyngeal cancer combination chemoradiation therapy based on folic acid modified, gefitinib and yttrium 90 co-loaded, core-shell structured lipid-polymer hybrid nanoparticles. , 2019, Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.

[3]  K. Adibkia,et al.  Preparation and physicochemical characterization of prazosin conjugated PLGA nanoparticles for drug delivery of flutamide , 2018 .

[4]  Jin Yao,et al.  Effect of nanoencapsulation using poly (lactide-co-glycolide) (PLGA) on anti-angiogenic activity of bevacizumab for ocular angiogenesis therapy. , 2018, Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.

[5]  D. Ma,et al.  A targeted nanocarrier based on polyspermine for the effective delivery of methotrexate in nasopharyngeal carcinoma. , 2017, Materials science & engineering. C, Materials for biological applications.

[6]  Zhibiao Liu,et al.  Folic acid inhibits nasopharyngeal cancer cell proliferation and invasion via activation of FRα/ERK1/2/TSLC1 pathway , 2017, Bioscience reports.

[7]  Hamideh Afrooz,et al.  Design and characterization of paclitaxel-verapamil co-encapsulated PLGA nanoparticles: Potential system for overcoming P-glycoprotein mediated MDR , 2017 .

[8]  Zhipeng Gu,et al.  Polymeric nanoparticles for colon cancer therapy: overview and perspectives. , 2016, Journal of materials chemistry. B.

[9]  Karthi Natesan,et al.  Pelargonidin induces apoptosis and cell cycle arrest via a mitochondria mediated intrinsic apoptotic pathway in HT29 cells , 2016 .

[10]  Wancai Yang,et al.  Surface modification of PLGA nanoparticles with biotinylated chitosan for the sustained in vitro release and the enhanced cytotoxicity of epirubicin. , 2016, Colloids and surfaces. B, Biointerfaces.

[11]  M. Kanter,et al.  Effects of Urtica dioica on oxidative stress, proliferation and apoptosis after partial hepatectomy in rats , 2015, Toxicology and industrial health.

[12]  Sarah A Heerboth,et al.  Drug Resistance in Cancer: An Overview , 2014, Cancers.

[13]  Qingming Luo,et al.  Nasopharyngeal cancer-specific therapy based on fusion peptide-functionalized lipid nanoparticles. , 2014, ACS nano.

[14]  Antonello A Barresi,et al.  Strategies to control the particle size distribution of poly-epsilon-caprolactone nanoparticles for pharmaceutical applications. , 2008, Journal of colloid and interface science.

[15]  T. Mosmann.  Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. , 1983, Journal of immunological methods.