Global stability of endemic equilibrium point of basic virus infection model with application to HBV infection

In this paper, the authors first show that if R0 ≤ 1, the infection free steady state is globally attractive by using approaches different from those given by Min, et al.(2008). Then the authors prove that if R0 > 1, the endemic steady state is also globally attractive. Finally, based on a patient’s clinical HBV DNA data of anti-HBV infection with drug lamivudine, the authors establish an ABVIM. The numerical simulations of the ABVIM are good in agreement with the clinical data.

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