PH oscillations in cell suspensions of Dictyostelium discoideum: their relation to cyclic-amp signals.

Cells of Dictyostelium discoideum known to release cyclic AMP (cAMP) rhythmically in the form of pulses, change with the same period of about 8 min the pH of their medium. The pH is used here as an indicator to investigate the effect of externally added cAMP pulses on the oscillations. Both a temporary increase in amplitude and a permanent phase shift can be induced. The phase-response curve indicates that the period can be increased and decreased by rhythmic stimulation with cAMP pulses.

[1]  G. Gerisch,et al.  Cyclic AMP-induced pH changes in Dictyostelium discoideum and their control by calcium. , 1978, Biochimica et biophysica acta.

[2]  A. Winfree.  Phase control of neural pacemakers. , 1977, Science.

[3]  G. Gerisch,et al.  Adenylate cyclase activity oscillations as signals for cell aggregation in Dictyostelium discoideum , 1977, Nature.

[4]  J. Gross,et al.  Signal emission and signal propagation during early aggregation in Dictyostelium discoideum. , 1976, Journal of cell science.

[5]  V. Nanjundiah,et al.  Effect of temperature on morphogenetic oscillations in Dictyostelium discoideum , 1976, Nature.

[6]  B. Wurster.  Temperature dependence of biochemical oscillations in cell suspensions of Dictyostelium discoideum , 1976, Nature.

[7]  G. Gerisch,et al.  Cell communication by periodic cyclic-AMP pulses. , 1975, Philosophical transactions of the Royal Society of London. Series B, Biological sciences.

[8]  G. Gerisch,et al.  Intracellular oscillations and release of cyclic AMP from Dictyostelium cells. , 1975, Biochemical and biophysical research communications.

[9]  B. M. SHAFFER,et al.  Secretion of cyclic AMP induced by cyclic AMP in the cellular slime mould Dictyostelium discoideum , 1975, Nature.

[10]  G. Gerisch,et al.  Amplification of cyclic‐AMP signals in aggregating cells of Dictyostelium discoideum , 1975, FEBS letters.

[11]  F. Alcântara,et al.  Signal propagation during aggregation in the slime mould Dictyostelium discoideum. , 1974, Journal of general microbiology.

[12]  B. Hess,et al.  Cyclic-AMP-controlled oscillations in suspended Dictyostelium cells: their relation to morphogenetic cell interactions. , 1974, Proceedings of the National Academy of Sciences of the United States of America.

[13]  A. Durston.  Pacemaker activity during aggregation in Dictyostelium discoideum. , 1974, Developmental biology.

[14]  A J Durston,et al.  Dictyostelium discoideum aggregation fields as excitable media. , 1973, Journal of theoretical biology.

[15]  M. Cohen,et al.  Control of Aggregation in Dictyostelium discoideum by an External Periodic Pulse of Cyclic Adenosine Monophosphate , 1972, Science.

[16]  J. Ashworth,et al.  Growth of myxameobae of the cellular slime mould Dictyostelium discoideum in axenic culture. , 1970, The Biochemical journal.

[17]  J. Bonner,et al.  The acrasin activity of adenosine-3',5'-cyclic phosphate. , 1967, Proceedings of the National Academy of Sciences of the United States of America.

[18]  J. Bonner,et al.  Evidence for the formation of cell aggregates by chemotaxis in the development of the slime mold Dictyostelium discoideum. , 1947, The Journal of experimental zoology.

[19]  G. Gerisch,et al.  CYCLIC AMP SIGNALS AND THE CONTROL OF CELL AGGREGATION IN DICTYOSTELIUM DISCOIDEUM , 1977 .

[20]  R. Kay,et al.  CELL CONTACT, SIGNALLING AND GENE EXPRESSION IN DICTYOSTELIUM DISCOIDEUM , 1977 .

[21]  G. Gerisch,et al.  Cyclic AMP receptors and the control of cell aggregation in Dictyostelium. , 1976, Advances in cyclic nucleotide research.

[22]  Theodosios Pavlidis,et al.  Biological Oscillators: Their Mathematical Analysis , 1973 .

[23]  T. M. Konijn.  Cyclic AMP as a first messenger. , 1972, Advances in cyclic nucleotide research.

[24]  Konijn Tm.  Cyclic AMP as a first messenger. , 1972 .

[25]  G Gerisch,et al.  Cell aggregation and differentiation in Dictyostelium. , 1968, Current topics in developmental biology.

[26]  Güunther Gerisch,et al.  Chapter 6 Cell Aggregation and Differentiation in Dictyostelium , 1968 .

[27]  G. P. Moore,et al.  PACEMAKER NEURONS: EFFECTS OF REGULARLY SPACED SYNAPTIC INPUT. , 1964, Science.