The insulin-like growth factor system as a treatment target in breast cancer.
暂无分享,去创建一个
[1] L. Hennighausen,et al. Circulating insulin-like growth factor-I levels regulate colon cancer growth and metastasis. , 2002, Cancer research.
[2] D. Yee,et al. Regulation of breast cancer cell motility by insulin receptor substrate-2 (IRS-2) in metastatic variants of human breast cancer cell lines , 2001, Oncogene.
[3] C. Boni,et al. Superior efficacy of letrozole versus tamoxifen as first-line therapy for postmenopausal women with advanced breast cancer: results of a phase III study of the International Letrozole Breast Cancer Group. , 2001, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
[4] D. Andrews,et al. Results of a pilot study involving the use of an antisense oligodeoxynucleotide directed against the insulin-like growth factor type I receptor in malignant astrocytomas. , 2001, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
[5] Adrian V. Lee,et al. Inability of Overexpressed des(1-3)Human Insulin-Like Growth Factor I (IGF-I) to Inhibit Forced Mammary Gland Involution Is Associated with Decreased Expression of IGF Signaling Molecules. , 2001, Endocrinology.
[6] Hans J. Berkel,et al. Free insulin‐like growth factor‐I and breast cancer risk , 2001 .
[7] R. Shore,et al. Serum insulin‐like growth factor‐I and breast cancer , 2000, International journal of cancer.
[8] A. Levitzki,et al. Substrate competitive inhibitors of IGF-1 receptor kinase. , 2000, Biochemistry.
[9] M. Karas,et al. The Potentiation of Estrogen on Insulin-like Growth Factor I Action in MCF-7 Human Breast Cancer Cells Includes Cell Cycle Components* , 2000, The Journal of Biological Chemistry.
[10] A. Buzdar,et al. Anastrozole is superior to tamoxifen as first-line therapy for advanced breast cancer in postmenopausal women: results of a North American multicenter randomized trial. Arimidex Study Group. , 2000, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
[11] J. Robertson,et al. Anastrozole versus tamoxifen as first-line therapy for advanced breast cancer in 668 postmenopausal women: results of the Tamoxifen or Arimidex Randomized Group Efficacy and Tolerability study. , 2000, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
[12] G. Spencer-Green. Etanercept (Enbrel): update on therapeutic use , 2000, Annals of the rheumatic diseases.
[13] P. Mease,et al. Etanercept in the treatment of psoriatic arthritis and psoriasis: a randomised trial , 2000, The Lancet.
[14] W. Willett,et al. Plasma insulin-like growth factor (IGF) I, IGF-binding protein 3, and mammographic density. , 2000, Cancer research.
[15] M. van Eickels,et al. Estrogen Receptor α Rapidly Activates the IGF-1 Receptor Pathway* , 2000, The Journal of Biological Chemistry.
[16] F. May,et al. Insulin Receptor Substrate-1 Expression Is Regulated by Estrogen in the MCF-7 Human Breast Cancer Cell Line* , 2000, The Journal of Biological Chemistry.
[17] Kristen L Murphy,et al. Cooperative interaction between mutant p53 and des(1-3)IGF-I accelerates mammary tumorigenesis , 2000, Oncogene.
[18] E. Solary,et al. Effects of cyclosporin at various concentrations on dexamethasone intracellular uptake in multidrug resistant cells , 2000, Annals of the rheumatic diseases.
[19] W. Lowe,et al. Insulin-Like Growth Factor I Activates c-Jun N-Terminal Kinase in MCF-7 Breast Cancer Cells1. , 2000, Endocrinology.
[20] V. Hwa,et al. The insulin-like growth factor-binding protein (IGFBP) superfamily. , 1999, Endocrine reviews.
[21] D. Yee,et al. Insulin‐like growth factor (IGF)‐I rescues breast cancer cells from chemotherapy‐induced cell death – proliferative and anti‐apoptotic effects , 1999, Breast Cancer Research and Treatment.
[22] R. Jirtle,et al. Altered ligand binding by insulin-like growth factor II/mannose 6-phosphate receptors bearing missense mutations in human cancers. , 1999, Cancer research.
[23] K. Siddle,et al. Insulin and insulin-like growth factor-I (IGF-I) receptor overexpression in breast cancers leads to insulin/IGF-I hybrid receptor overexpression: evidence for a second mechanism of IGF-I signaling. , 1999, Clinical cancer research : an official journal of the American Association for Cancer Research.
[24] B. Bozkurt,et al. Safety and efficacy of a soluble P75 tumor necrosis factor receptor (Enbrel, etanercept) in patients with advanced heart failure. , 1999, Circulation.
[25] S. Hilsenbeck,et al. Enhancement of insulin-like growth factor signaling in human breast cancer: estrogen regulation of insulin receptor substrate-1 expression in vitro and in vivo. , 1999, Molecular endocrinology.
[26] S. Hanauer,et al. Antitumor necrosis factor therapy for inflammatory bowel disease: a review of agents, pharmacology, clinical results, and safety. , 1999, Inflammatory bowel diseases.
[27] A. Costantino,et al. Insulin Receptor Isoform A, a Newly Recognized, High-Affinity Insulin-Like Growth Factor II Receptor in Fetal and Cancer Cells , 1999, Molecular and Cellular Biology.
[28] A. Costantino,et al. Insulin receptor activation by IGF-II in breast cancers: evidence for a new autocrine/paracrine mechanism , 1999, Oncogene.
[29] D. Furst,et al. Etanercept Therapy in Rheumatoid Arthritis , 1999, Annals of Internal Medicine.
[30] P. Cohen,et al. Insulin-Like Growth Factor Binding Proteins: New Proteins, New Functions , 1999, Hormone Research in Paediatrics.
[31] Osborne Ck,et al. Tamoxifen in the Treatment of Breast Cancer , 1998 .
[32] C. Mantzoros,et al. Insulin-like growth factor-I in relation to premenopausal ductal carcinoma in situ of the breast. , 1998, Epidemiology.
[33] Sandra,et al. A dominant negative mutant of the insulin-like growth factor-I receptor inhibits the adhesion, invasion, and metastasis of breast cancer. , 1998, Cancer research.
[34] J. Holly. Insulin-like growth factor-I and new opportunities for cancer prevention , 1998, The Lancet.
[35] David J Hunter,et al. Circulating concentrations of insulin-like growth factor I and risk of breast cancer , 1998, The Lancet.
[36] D. Yee,et al. Insulin Receptor Substrate-1 is the Predominant Signaling Molecule Activated by Insulin-like Growth Factor-I, Insulin, and Interleukin-4 in Estrogen Receptor-positive Human Breast Cancer Cells* , 1998, The Journal of Biological Chemistry.
[37] N. Webster,et al. Elevated insulin-like growth factor I receptor autophosphorylation and kinase activity in human breast cancer. , 1998, Cancer research.
[38] Adrian V. Lee,et al. Igf system components as prognostic markers in breast cancer , 1998, Breast Cancer Research and Treatment.
[39] A. Leaf,et al. Mannose-6-phosphate/insulin-like growth factor-II receptor is a receptor for retinoic acid. , 1997, Proceedings of the National Academy of Sciences of the United States of America.
[40] B. van der Burg,et al. Mitogenic Signaling of Insulin-like Growth Factor I in MCF-7 Human Breast Cancer Cells Requires Phosphatidylinositol 3-Kinase and Is Independent of Mitogen-activated Protein Kinase* , 1997, The Journal of Biological Chemistry.
[41] P. Delafontaine,et al. Estrogen effects on insulin-like growth factor-I (IGF-I)-induced cell proliferation and IGF-I expression in native and allograft vessels. , 1997, Circulation.
[42] P. Glazer,et al. Insulin-like growth factor-I receptor overexpression mediates cellular radioresistance and local breast cancer recurrence after lumpectomy and radiation. , 1997, Cancer research.
[43] S. J. Taylor,et al. Insulin-like growth factor I receptor signaling in transformation by src oncogenes , 1997, Molecular and cellular biology.
[44] M. Rubini,et al. The IGF-I receptor in cell growth, transformation and apoptosis. , 1997, Biochimica et biophysica acta.
[45] S. Hilsenbeck,et al. Polyethylene glycol conjugated insulin-like growth factor binding protein-1 (IGFBP-1) inhibits growth of breast cancer in athymic mice. , 1997, European journal of cancer.
[46] A. Louvi,et al. Insulin-like growth factor II stimulates cell proliferation through the insulin receptor. , 1997, Proceedings of the National Academy of Sciences of the United States of America.
[47] D. Leroith,et al. Insulin-Like Growth Factor-1 Inhibition of Apoptosis Is Associated with Increased Expression of the bcl-xL Gene Product. , 1997, Endocrinology.
[48] L. Hennighausen,et al. Involution of the lactating mammary gland is inhibited by the IGF system in a transgenic mouse model. , 1996, The Journal of clinical investigation.
[49] R. Bentley,et al. M6P/IGF2 receptor: a candidate breast tumor suppressor gene. , 1996, Oncogene.
[50] Z. Gucev,et al. Insulin-like Growth Factor Binding Protein 3 Mediates Retinoic Acid- and Transforming Growth Factor β2-induced Growth Inhibition in Human Breast Cancer Cells , 1996 .
[51] D Tripathy,et al. Phase II study of weekly intravenous recombinant humanized anti-p185HER2 monoclonal antibody in patients with HER2/neu-overexpressing metastatic breast cancer. , 1996, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
[52] M E Doerr,et al. The Roles of Integrins and Extracellular Matrix Proteins in the Insulin-like Growth Factor I-stimulated Chemotaxis of Human Breast Cancer Cells (*) , 1996, The Journal of Biological Chemistry.
[53] P. Delafontaine. Insulin-like growth factor I and its binding proteins in the cardiovascular system. , 1995, Cardiovascular research.
[54] R. Baserga,et al. Insulin-like growth factor-I receptor. Its role in cell proliferation, apoptosis, and tumorigenicity. , 1995, Laboratory investigation; a journal of technical methods and pathology.
[55] C T Roberts,et al. Molecular and cellular aspects of the insulin-like growth factor I receptor. , 1995, Endocrine reviews.
[56] R. Wieczorek,et al. Estradiol enhances the stimulatory effect of insulin-like growth factor-I (IGF-I) on mammary development and growth hormone-induced IGF-I messenger ribonucleic acid. , 1995, Endocrinology.
[57] S. McLeskey,et al. Emergence of MCF-7 cells overexpressing a transfected epidermal growth factor receptor (EGFR) under estrogen-depleted conditions: evidence for a role of EGFR in breast cancer growth and progression. , 1994, Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research.
[58] D. Coppola,et al. A functional insulin-like growth factor I receptor is required for the mitogenic and transforming activities of the epidermal growth factor receptor , 1994, Molecular and cellular biology.
[59] P. Porcu,et al. The role of the insulin-like growth factor I receptor in the transformation by simian virus 40 T antigen. , 1994, Oncogene.
[60] M. Rubini,et al. Simian virus 40 large tumor antigen is unable to transform mouse embryonic fibroblasts lacking type 1 insulin-like growth factor receptor. , 1993, Proceedings of the National Academy of Sciences of the United States of America.
[61] S. Hilsenbeck,et al. Recombinant insulin‐like growth factor binding protein‐1 inhibits IGF‐I, serum, and estrogen‐dependent growth of MCF‐7 human breast cancer cells , 1993, Journal of cellular physiology.
[62] V. Schirrmacher,et al. EGF receptor in neoplasia and metastasis , 1993, Cancer and Metastasis Reviews.
[63] G M Clark,et al. Insulin-like growth factor-I receptors are overexpressed and predict a low risk in human breast cancer. , 1993, Cancer research.
[64] R. Rosenfeld,et al. Insulin-like growth factor (IGF)-independent action of IGF-binding protein-3 in Hs578T human breast cancer cells. Cell surface binding and growth inhibition. , 1993, The Journal of biological chemistry.
[65] B. Katzenellenbogen,et al. Stimulation of estrogen receptor-mediated transcription and alteration in the phosphorylation state of the rat uterine estrogen receptor by estrogen, cyclic adenosine monophosphate, and insulin-like growth factor-I. , 1993, Molecular endocrinology.
[66] C. Roberts,et al. Role of tyrosine kinase activity in signal transduction by the insulin-like growth factor-I (IGF-I) receptor. Characterization of kinase-deficient IGF-I receptors and the action of an IGF-I-mimetic antibody (alpha IR-3). , 1993, The Journal of biological chemistry.
[67] D. Yee,et al. Regulation of insulin-like growth factor-binding protein (IGFBP) expression by breast cancer cells: use of IGFBP-1 as an inhibitor of insulin-like growth factor action. , 1992, Journal of the National Cancer Institute.
[68] D. Clemmons,et al. Phosphorylation of insulin-like growth factor (IGF)-binding protein 1 in cell culture and in vivo: effects on affinity for IGF-I. , 1991, Proceedings of the National Academy of Sciences of the United States of America.
[69] M. Johnson,et al. Role of insulin-like growth factors and the type I insulin-like growth factor receptor in the estrogen-stimulated proliferation of human breast cancer cells. , 1990, The Journal of biological chemistry.
[70] R. Humbel,et al. Insulin-like growth factors I and II. , 1990, European journal of biochemistry.
[71] W. Rutter,et al. Overexpression of the human insulinlike growth factor I receptor promotes ligand-dependent neoplastic transformation , 1990, Molecular and cellular biology.
[72] C. Osborne,et al. Growth inhibition of human breast cancer cells in vitro with an antibody against the type I somatomedin receptor. , 1989, Cancer research.
[73] C. Osborne,et al. Blockade of the type I somatomedin receptor inhibits growth of human breast cancer cells in athymic mice. , 1989, The Journal of clinical investigation.
[74] P. Rotwein,et al. Insulin-like growth factors I and II. Peptide, messenger ribonucleic acid and gene structures, serum, and tissue concentrations. , 1989, Endocrine reviews.
[75] D. Yee,et al. Insulin-like growth factor II mRNA expression in human breast cancer. , 1988, Cancer research.
[76] W. Rutter,et al. Expression and characterization of a functional human insulin-like growth factor I receptor. , 1988, The Journal of biological chemistry.
[77] R. Roth. Structure of the receptor for insulin-like growth factor II: the puzzle amplified. , 1988, Science.
[78] A. Ullrich,et al. A single receptor binds both insulin-like growth factor II and mannose-6-phosphate. , 1988, Science.
[79] W. Rutter,et al. Insulin-like growth factor II receptor as a multifunctional binding protein , 1987, Nature.
[80] C Collins,et al. Insulin‐like growth factor I receptor primary structure: comparison with insulin receptor suggests structural determinants that define functional specificity. , 1986, The EMBO journal.
[81] S. Plymate,et al. The insulin-like growth factor-binding protein superfamily. , 2000, Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society.
[82] G. Romano,et al. Insulin and IGF-I Receptors Signaling in Protection from Apoptosis , 1999, Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme.
[83] W. Ruan,et al. Insulin-like growth factor I is essential for terminal end bud formation and ductal morphogenesis during mammary development. , 1999, Endocrinology.
[84] S. Hilsenbeck,et al. Insulin-like growth factor binding protein-3 and insulin receptor substrate-1 in breast cancer: correlation with clinical parameters and disease-free survival. , 1997, Clinical cancer research : an official journal of the American Association for Cancer Research.
[85] D. Yee,et al. Activation of estrogen receptor-mediated gene transcription by IGF-I in human breast cancer cells. , 1997, The Journal of endocrinology.
[86] J. Rosen,et al. Targeted expression of des(1-3) human insulin-like growth factor I in transgenic mice influences mammary gland development and IGF-binding protein expression. , 1996, Endocrinology.
[87] D. Yee,et al. Pharmacokinetic profile of recombination human insulin-like growth factor binding protein-1 in athymic mice. , 1996, Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
[88] M. Hershfield,et al. Enzyme Replacement Therapy with Polyethylene Glycol-Adenosine Deaminase in Adenosine Deaminase Deficiency: Overview and Case Reports of Three Patients, Including Two Now Receiving Gene Therapy , 1993, Pediatric Research.
[89] S. Kornfeld. Structure and function of the mannose 6-phosphate/insulinlike growth factor II receptors. , 1992, Annual review of biochemistry.
[90] S. Jacobs,et al. Interaction of the Monoclonal Antibodies αlR-1 and αIR-3 with Insulin and Somatomedin-C Receptors , 1986 .
[91] A. Levitzki,et al. Printed in U.S.A. Copyright © 1997 by The Endocrine Society Specific Inhibition of Insulin-Like Growth Factor-1 and Insulin Receptor Tyrosine Kinase Activity and Biological Function by Tyrphostins , 2022 .