Development of SH2 probes and pull‐down assays to detect pathogen‐induced, site‐specific tyrosine phosphorylation of the TLR adaptor SCIMP

[1]  M. Sweet,et al.  SCIMP is a transmembrane non-TIR TLR adaptor that promotes proinflammatory cytokine production from macrophages , 2017, Nature Communications.

[2]  B. Malissen,et al.  The Transmembrane Adaptor Protein SCIMP Facilitates Sustained Dectin-1 Signaling in Dendritic Cells* , 2016, The Journal of Biological Chemistry.

[3]  J. Králová,et al.  PSTPIP2, a Protein Associated with Autoinflammatory Disease, Interacts with Inhibitory Enzymes SHIP1 and Csk , 2015, The Journal of Immunology.

[4]  J. Stow,et al.  Single‐step protease cleavage elution for identification of protein–protein interactions from GST pull‐down and mass spectrometry , 2014, Proteomics.

[5]  A. Weiss,et al.  SCIMP, a Transmembrane Adaptor Protein Involved in Major Histocompatibility Complex Class II Signaling , 2011, Molecular and Cellular Biology.

[6]  L. Nitschke,et al.  Grb2 regulates B‐cell maturation, B‐cell memory responses and inhibits B‐cell Ca2+ signalling , 2011, The EMBO journal.

[7]  E. Komives,et al.  Interactions of the NPXY microdomains of the low density lipoprotein receptor‐related protein 1 , 2009, Proteomics.

[8]  Adam Byron,et al.  Proteomic Analysis of Integrin-Associated Complexes Identifies RCC2 as a Dual Regulator of Rac1 and Arf6 , 2009, Science Signaling.

[9]  T. Hunter.  Tyrosine phosphorylation: thirty years and counting. , 2009, Current opinion in cell biology.

[10]  T. Pawson,et al.  The human and mouse complement of SH2 domain proteins-establishing the boundaries of phosphotyrosine signaling. , 2006, Molecular cell.

[11]  S. Hubbard,et al.  Structural Characterization of a Novel Cbl Phosphotyrosine Recognition Motif in the APS Family of Adapter Proteins* , 2005, Journal of Biological Chemistry.

[12]  A. Yoshimura,et al.  Modulation of TLR signalling by the C‐terminal Src kinase (Csk) in macrophages , 2005, Genes to cells : devoted to molecular & cellular mechanisms.

[13]  Tony Pawson,et al.  Specificity in Signal Transduction From Phosphotyrosine-SH2 Domain Interactions to Complex Cellular Systems , 2004, Cell.

[14]  J. Mandell,et al.  Phosphorylation state-specific antibodies: applications in investigative and diagnostic pathology. , 2003, The American journal of pathology.

[15]  C. Sawyers.  Rational therapeutic intervention in cancer: kinases as drug targets. , 2002, Current opinion in genetics & development.

[16]  S. Tomita,et al.  BLNK is associated with the CD72 / SHP‐1 / Grb2 complex in the WEHI231 cell line after membrane IgM cross‐linking , 2000, European journal of immunology.

[17]  J. M. Bradshaw,et al.  Investigation of phosphotyrosine recognition by the SH2 domain of the Src kinase. , 1999, Journal of molecular biology.

[18]  J. M. Bradshaw,et al.  Calorimetric examination of high-affinity Src SH2 domain-tyrosyl phosphopeptide binding: dissection of the phosphopeptide sequence specificity and coupling energetics. , 1999, Biochemistry.

[19]  Alexander Levitzki,et al.  Activation of the Ras/Mitogen-Activated Protein Kinase Pathway by Kinase-Defective Epidermal Growth Factor Receptors Results in Cell Survival but Not Proliferation , 1998, Molecular and Cellular Biology.

[20]  H. Lester,et al.  Asymmetrical contributions of subunit pore regions to ion selectivity in an inward rectifier K+ channel. , 1998, Biophysical journal.

[21]  Bernd Wollscheid,et al.  SLP-65: A New Signaling Component in B Lymphocytes which Requires Expression of the Antigen Receptor for Phosphorylation , 1998, The Journal of experimental medicine.

[22]  C. Turck,et al.  BLNK: a central linker protein in B cell activation. , 1998, Immunity.

[23]  S. Arkinstall,et al.  Activation of phospholipase C gamma in Schizosaccharomyces pombe by coexpression of receptor or nonreceptor tyrosine kinases , 1995, Molecular and cellular biology.

[24]  T. Pawson,et al.  SH2 domains recognize specific phosphopeptide sequences , 1993, Cell.

[25]  D. Baltimore,et al.  The noncatalytic src homology region 2 segment of abl tyrosine kinase binds to tyrosine-phosphorylated cellular proteins with high affinity. , 1991, Proceedings of the National Academy of Sciences of the United States of America.

[26]  Prof. Dr. Pavol Quittner,et al.  Systems , 2019, Superlinear Parabolic Problems.

[27]  T. Winkler,et al.  Grb 2 regulates B-cell maturation , B-cell memory responses and inhibits B-cell Ca 2 þ signalling , 2011 .

[28]  Nunzio Bottini,et al.  Protein tyrosine phosphatases and the immune response , 2005, Nature Reviews Immunology.

[29]  L. Johnson,et al.  The effects of phosphorylation on the structure and function of proteins. , 1993, Annual review of biophysics and biomolecular structure.