Low-Dose Gamma-Radiation Inhibits Benzo[a]pyrene-Induced Lung Adenoma Development in A/J Mice

Low-dose ionizing radiation (LDR) may lead to suppression of smoking-related lung cancer. We examined the effects of a known cigarette smoke carcinogen Benzo[a]pyrene (B[a]P) alone or in combination with fractionated low-dose gamma radiation (60 – 600 mGy total dose) on the induction of lung neoplasms in the A/J mouse. Our results show that 600 mGy of gamma radiation delivered in six biweekly fractions of 100 mGy starting 1 month after B[a]P injection significantly inhibits the development of lung adenomas per animal induced by B[a]P. Our data also indicated that the six biweekly doses suppressed the occurrence of spontaneous hyperplastic foci in the lung, although this suppression failed to reach statistical significance when analyzed as average foci per lung possibly related to the small sample sizes used for the control and test groups.

[1]  T. March,et al.  Small γ-Ray Doses Prevent Rather than Increase Lung Tumors in Mice , 2012, Dose-response : a publication of International Hormesis Society.

[2]  C. L. Sanders.  Potential Treatment of Inflammatory and Proliferative Diseases by Ultra-Low Doses of Ionizing Radiations , 2012, Dose-response : a publication of International Hormesis Society.

[3]  B. Scott.  Residential Radon Appears to Prevent Lung Cancer , 2011, Dose-response : a publication of International Hormesis Society.

[4]  S. Leng,et al.  EMT and stem cell-like properties associated with miR-205 and miR-200 epigenetic silencing are early manifestations during carcinogen-induced transformation of human lung epithelial cells. , 2011, Cancer research.

[5]  Ewa M Nowosielska,et al.  Anti-neoplastic and immunostimulatory effects of low-dose X-ray fractions in mice , 2011, International journal of radiation biology.

[6]  S. Belinsky,et al.  Rosiglitazone prevents the progression of preinvasive lung cancer in a murine model. , 2007, Carcinogenesis.

[7]  I. Rahman,et al.  Current concepts on the role of inflammation in COPD and lung cancer. , 2009, Current opinion in pharmacology.

[8]  S. Leng,et al.  Radiation-Stimulated Epigenetic Reprogramming of Adaptive-Response Genes in the Lung: An Evolutionary Gift for Mounting Adaptive Protection against Lung Cancer , 2009, Dose-response : a publication of International Hormesis Society.

[9]  Gina Lee,et al.  Smoking and lung cancer: the role of inflammation. , 2008, Proceedings of the American Thoracic Society.

[10]  A. Kozubík,et al.  Tumor necrosis factor-alpha potentiates genotoxic effects of benzo[a]pyrene in rat liver epithelial cells through upregulation of cytochrome P450 1B1 expression. , 2008, Mutation research.

[11]  J. Popkin,et al.  CASE-CONTROL STUDY OF LUNG CANCER RISK FROM RESIDENTIAL RADON EXPOSURE IN WORCESTER COUNTY, MASSACHUSETTS , 2008, Health physics.

[12]  C. L. Sanders,et al.  CT Scans May Reduce Rather than Increase the Risk of Cancer , 2008 .

[13]  B. Scott.  Low-Dose Radiation-Induced Protective Process and Implications for Risk Assessment, Cancer Prevention, and Cancer Therapy , 2007, Dose-response : a publication of International Hormesis Society.

[14]  C. L. Sanders,et al.  Smoking and Hormesis as Confounding Factors in Radiation Pulmonary Carcinogenesis , 2008, Dose-response : a publication of International Hormesis Society.

[15]  Shu-zheng Liu,et al.  Cancer Control Related to Stimulation of Immunity by Low-Dose Radiation , 2007, Dose-response : a publication of International Hormesis Society.

[16]  T. Nomura,et al.  Enhancement of Bio-Protective Functions by Low Dose/Dose-Rate Radiation , 2006, Dose-response : a publication of International Hormesis Society.

[17]  S. De Flora,et al.  Influence of FHIT on benzo[a]pyrene-induced tumors and alopecia in mice: Chemoprevention by budesonide and N-acetylcysteine , 2006, Proceedings of the National Academy of Sciences of the United States of America.

[18]  E. Lisiak,et al.  Single Low Doses of X Rays Inhibit the Development of Experimental Tumor Metastases and Trigger the Activities of NK Cells in Mice , 2004, Radiation research.

[19]  J. Herman,et al.  Inhibition of DNA methylation and histone deacetylation prevents murine lung cancer. , 2003, Cancer research.

[20]  Shu-zheng Liu.  Nonlinear Dose-Response Relationship in the Immune System following Exposure to Ionizing Radiation: Mechanisms and Implications , 2003, Nonlinearity in biology, toxicology, medicine.

[21]  T. Iwasaki,et al.  Suppression of carcinogenic processes in mice by chronic low dose rate gamma-irradiation , 2003 .

[22]  L. Cai.  Research of the adaptive response induced by low-dose radiation: where have we been and where should we go? , 1999, Human & experimental toxicology.

[23]  坂本 澄彦,et al.  FUNDAMENTAL AND CLINICAL STUDIES ON CANCER CONTROL WITH TOTAL OR UPPER HALF BODY IRRADIATION , 1997 .

[24]  B. Cohen,et al.  Lung cancer rate vs. mean radon level in U.S. counties of various characteristics. , 1997, Health physics.

[25]  M. Tang,et al.  Preferential Formation of Benzo[a]pyrene Adducts at Lung Cancer Mutational Hotspots in P53 , 1996, Science.

[26]  S. Hecht,et al.  Lung tumor induction in A/J mice by the tobacco smoke carcinogens 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone and benzo[a]pyrene: a potentially useful model for evaluation of chemopreventive agents. , 1994, Carcinogenesis.

[27]  Y. Hosoi,et al.  Suppressive effect of low dose total body irradiation on lung metastasis: dose dependency and effective period. , 1993, Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology.

[28]  A. Malkinson.  Primary lung tumors in mice: an experimentally manipulable model of human adenocarcinoma. , 1992, Cancer research.

[29]  L. Alfred,et al.  Immunocytotoxicity effects of polycyclic aromatic hydrocarbons on mouse lymphocytes. , 1984, Toxicology.

[30]  R. Ullrich,et al.  Influence of gamma irradiation on the development of neoplastic disease in mice. II. Solid tumors. , 1979, Radiation research.

[31]  R. Ullrich,et al.  Influence of y Irradiation on the Development of Neoplastic Disease in Mice , 1979 .