Approximately 600,000 routine immunohematological tests have been conducted with Groupamatic GC systems at the National Blood Transfusion Center in Paris. The system is used for determination of the ABO group including A1 and A2 subgrouping; the Rh factors including Du, C, c, E, e, Cw; K; Lea; P1; M and N. The detection and identification of irregular alloantibodies is carried out systematically together with detection of the anti‐A and anti‐B antibodies. Simultaneously, testing for syphilis is done with a cardiolipid antigen. Groupamatic equipment allows 340 samples to be tested per hour and 12 reactions can be carried out simultaneously on each sample. The system is fully automated.