A yeast platform for high-level synthesis of tetrahydroisoquinoline alkaloids

[1]  J. Pleiss,et al.  Acceptance and Kinetic Resolution of α-Methyl-Substituted Aldehydes by Norcoclaurine Synthases , 2019, ACS Catalysis.

[2]  S. Yeaman,et al.  Neopinone isomerase is involved in codeine and morphine biosynthesis in opium poppy , 2019, Nature Chemical Biology.

[3]  Antonios M. Makris,et al.  Synthesis of 11-carbon terpenoids in yeast using protein and metabolic engineering , 2018, Nature Chemical Biology.

[4]  P. Facchini,et al.  Benzylisoquinoline Alkaloids Biosynthesis in Sacred Lotus , 2018, Molecules.

[5]  V. Martin,et al.  A Highly Characterized Synthetic Landing Pad System for Precise Multicopy Gene Integration in Yeast. , 2018, ACS synthetic biology.

[6]  Xi Li,et al.  Functions of aldehyde reductases from Saccharomyces cerevisiae in detoxification of aldehyde inhibitors and their biotechnological applications , 2018, Applied Microbiology and Biotechnology.

[7]  V. Martin,et al.  An Engineered Aro1 Protein Degradation Approach for Increased cis,cis-Muconic Acid Biosynthesis in Saccharomyces cerevisiae , 2018, Applied and Environmental Microbiology.

[8]  Xue Chen,et al.  A pathogenesis-related 10 protein catalyzes the final step in thebaine biosynthesis , 2018, Nature Chemical Biology.

[9]  F. Sato,et al.  Microbial production of novel sulphated alkaloids for drug discovery , 2018, Scientific Reports.

[10]  Yanran Li,et al.  Complete biosynthesis of noscapine and halogenated alkaloids in yeast , 2018, Proceedings of the National Academy of Sciences.

[11]  J. L. Mateo,et al.  Refined sgRNA efficacy prediction improves large- and small-scale CRISPR–Cas9 applications , 2017, Nucleic acids research.

[12]  Neil K Garg,et al.  Engineering the biocatalytic selectivity of iridoid production in Saccharomyces cerevisiae. , 2017, Metabolic engineering.

[13]  Benjamin R. Lichman,et al.  Enzyme catalysed Pictet-Spengler formation of chiral 1,1'-disubstituted- and spiro-tetrahydroisoquinolines , 2017, Nature Communications.

[14]  Pamela Peralta-Yahya,et al.  Accelerating the semisynthesis of alkaloid-based drugs through metabolic engineering. , 2017, Nature chemical biology.

[15]  Jay D. Keasling,et al.  A Cas9-based toolkit to program gene expression in Saccharomyces cerevisiae , 2016, Nucleic acids research.

[16]  J. Willison,et al.  Mechanistic Details of Early Steps in Coenzyme Q Biosynthesis Pathway in Yeast. , 2016, Cell chemical biology.

[17]  Kate Campbell,et al.  Saccharomyces cerevisiae single-copy plasmids for auxotrophy compensation, multiple marker selection, and for designing metabolically cooperating communities , 2016, F1000Research.

[18]  Peter Jackson,et al.  Rewriting yeast central carbon metabolism for industrial isoprenoid production , 2016, Nature.

[19]  Yanran Li,et al.  Engineering biosynthesis of the anticancer alkaloid noscapine in yeast , 2016, Nature Communications.

[20]  Andrew Diamond,et al.  Metabolic engineering for the production of plant isoquinoline alkaloids. , 2016, Plant biotechnology journal.

[21]  A. Aharoni,et al.  Elucidation of the first committed step in betalain biosynthesis enables the heterologous engineering of betalain pigments in plants. , 2016, The New phytologist.

[22]  Ronald W. Davis,et al.  Quantitative CRISPR interference screens in yeast identify chemical-genetic interactions and new rules for guide RNA design , 2016, Genome Biology.

[23]  V. V. Symonds,et al.  Tyrosine Hydroxylation in Betalain Pigment Biosynthesis Is Performed by Cytochrome P450 Enzymes in Beets (Beta vulgaris) , 2016, PloS one.

[24]  F. Sato,et al.  Total biosynthesis of opiates by stepwise fermentation using engineered Escherichia coli , 2016, Nature Communications.

[25]  Christopher A. Voigt,et al.  Synthetic biology to access and expand nature's chemical diversity , 2016, Nature Reviews Microbiology.

[26]  Hee-Ju Nah,et al.  Precise cloning and tandem integration of large polyketide biosynthetic gene cluster using Streptomyces artificial chromosome system , 2015, Microbial Cell Factories.

[27]  C. Smolke,et al.  Complete biosynthesis of opioids in yeast , 2015, Science.

[28]  C. Smolke,et al.  De novo production of the key branch point benzylisoquinoline alkaloid reticuline in yeast. , 2015, Metabolic engineering.

[29]  Max G Schubert,et al.  Efficient Multiplexed Integration of Synergistic Alleles and Metabolic Pathways in Yeasts via CRISPR-Cas. , 2015, Cell systems.

[30]  Zachary N. Russ,et al.  An enzyme-coupled biosensor enables (S)-reticuline production in yeast from glucose. , 2015, Nature chemical biology.

[31]  Radhakrishnan Mahadevan,et al.  Metabolic engineering of a tyrosine-overproducing yeast platform using targeted metabolomics , 2015, Microbial Cell Factories.

[32]  G. Wong,et al.  Lineage-specific gene radiations underlie the evolution of novel betalain pigmentation in Caryophyllales , 2015, The New phytologist.

[33]  V. Martin,et al.  Synthesis of Morphinan Alkaloids in Saccharomyces cerevisiae , 2015, PloS one.

[34]  Benjamin R. Lichman,et al.  ‘Dopamine-first’ mechanism enables the rational engineering of the norcoclaurine synthase aldehyde activity profile , 2015, The FEBS journal.

[35]  Aditya M. Kunjapur,et al.  Microbial Engineering for Aldehyde Synthesis , 2015, Applied and Environmental Microbiology.

[36]  D. Maresch,et al.  Development of a fed-batch process for a recombinant Pichia pastoris Δoch1 strain expressing a plant peroxidase , 2015, Microbial Cell Factories.

[37]  迈克尔·谢里夫·西迪基,et al.  Benzylisoquinoline alkaloid (bia) precursor producing microbes, and methods of making and using the same , 2014 .

[38]  Jamie H. D. Cate,et al.  Selection of chromosomal DNA libraries using a multiplex CRISPR system , 2014, eLife.

[39]  Aditya M. Kunjapur,et al.  Synthesis and accumulation of aromatic aldehydes in an engineered strain of Escherichia coli. , 2014, Journal of the American Chemical Society.

[40]  David S. Wishart,et al.  CFM-ID: a web server for annotation, spectrum prediction and metabolite identification from tandem mass spectra , 2014, Nucleic Acids Res..

[41]  F. Sato,et al.  Asymmetric synthesis of tetrahydroisoquinolines by enzymatic Pictet–Spengler reaction , 2014, Bioscience, biotechnology, and biochemistry.

[42]  P. Facchini,et al.  Benzylisoquinoline alkaloid biosynthesis in opium poppy , 2014, Planta.

[43]  V. Martin,et al.  Reconstitution of a 10-gene pathway for synthesis of the plant alkaloid dihydrosanguinarine in Saccharomyces cerevisiae , 2014, Nature Communications.

[44]  J. Sanglier.  Faculty Opinions recommendation of Natural products: a continuing source of novel drug leads. , 2013 .

[45]  David J Newman,et al.  Natural products: a continuing source of novel drug leads. , 2013, Biochimica et biophysica acta.

[46]  P. Facchini,et al.  Benzylisoquinoline alkaloid metabolism: a century of discovery and a brave new world. , 2013, Plant & cell physiology.

[47]  J. Keasling,et al.  High-level semi-synthetic production of the potent antimalarial artemisinin , 2013, Nature.

[48]  H. Hailes,et al.  The Catalytic Potential of Coptis japonica NCS2 Revealed – Development and Utilisation of a Fluorescamine‐Based Assay , 2012 .

[49]  C. Veeresham.  Natural products derived from plants as a source of drugs , 2012, Journal of advanced pharmaceutical technology & research.

[50]  B. G. Hansen,et al.  Microbial production of indolylglucosinolate through engineering of a multi-gene pathway in a versatile yeast expression platform. , 2012, Metabolic engineering.

[51]  S. Bräse,et al.  Biocatalytic production of tetrahydroisoquinolines. , 2012, Tetrahedron letters.

[52]  Keith E. J. Tyo,et al.  Isoprenoid Pathway Optimization for Taxol Precursor Overproduction in Escherichia coli , 2010, Science.

[53]  Verena Siewers,et al.  Characterization of chromosomal integration sites for heterologous gene expression in Saccharomyces cerevisiae , 2009, Yeast.

[54]  Rachel B. Brem,et al.  Polymorphisms in Multiple Genes Contribute to the Spontaneous Mitochondrial Genome Instability of Saccharomyces cerevisiae S288C Strains , 2009, Genetics.

[55]  Zengyi Shao,et al.  DNA assembler, an in vivo genetic method for rapid construction of biochemical pathways , 2008, Nucleic acids research.

[56]  Kristy M. Hawkins,et al.  Production of benzylisoquinoline alkaloids in Saccharomyces cerevisiae. , 2008, Nature chemical biology.

[57]  J. Pronk,et al.  The Ehrlich Pathway for Fusel Alcohol Production: a Century of Research on Saccharomyces cerevisiae Metabolism , 2008, Applied and Environmental Microbiology.

[58]  J. Liao,et al.  Non-fermentative pathways for synthesis of branched-chain higher alcohols as biofuels , 2008, Nature.

[59]  F. Sato,et al.  Functional Analysis of Norcoclaurine Synthase in Coptis japonica* , 2007, Journal of Biological Chemistry.

[60]  Albert Sickmann,et al.  Proteomic analysis of the yeast mitochondrial outer membrane reveals accumulation of a subclass of preproteins. , 2005, Molecular biology of the cell.

[61]  E. Ellis,et al.  Characterization of Ypr1p from Saccharomyces cerevisiae as a 2‐methylbutyraldehyde reductase , 2002, Yeast.

[62]  K. L. Khanna,et al.  Biosynthesis of phenolic tetrahydroisoquinoline alkaloids of peyote , 1970 .

[63]  J. Pleiss,et al.  The Acceptance and Kinetic Resolution of alpha-Methyl Substituted Aldehydes by Norcoclaurine Synthases , 2019 .

[64]  Zachary N. Russ,et al.  Bioproduction of a betalain color palette in Saccharomyces cerevisiae. , 2018, Metabolic engineering.

[65]  J. Hoheisel,et al.  A transcriptome analysis of isoamyl alcohol-induced filamentation in yeast reveals a novel role for Gre2p as isovaleraldehyde reductase. , 2007, FEMS yeast research.

[66]  D. O'donovan,et al.  The biosynthesis of lophocerine. , 1968, Journal of The Chemical Society-perkin Transactions 1.