VTK CISG Registration Toolkit: An Open Source Software Package for Affine and Nonrigid Registration of Single- and Multimodal 3D images

Voxel-based image registration using Normalised Mutual Information (NMI) has been shown to register single- and multi-modal 3D images accurately without any user interaction [1,5,4]. Our group has proposed both an affine and a non-rigid registration algorithm based on NMI, and has validated these algorithms on a range of medical applications like brain, breast, and cardiac data [7, 8, 6, 2, 3]. We present a publicly available software package that incorporates these algorithms in a user-friendly command-line and graphical interface including a visualisation tool for 3D image pairs in order to analyse registration results. Beside the pure usage of registration algorithms, the software can be easily adjusted to specific environments (e.g. including other image file formats) and can be modified for specific applications.