Regulation Effect of Insulin on Metabolic Dysfunction of Diabetic Rats

The objective of this research was to observe the regulatory effects of insulin on lipid,protein and radical metabolic dysfunction,and its Anti|oxidative effect on the liver and body in Diabetic rats.Rats were injected iv with alloxan 40?mg/kg to induce diabetes.Insulin 0^5?U/kg s.c administered daily for 8 weeks obviously increased the body weight of diabetic rats.Insulin 1?U/kg s.c daily for 6 weeks improved the amount of TC,TP,Alb,decreased the amount of TG.Insulin 1?U/kg s.c daily for 9 days improved the activity of T|SOD,GSH|Px,reduced the activity of XOD in the blood serum of diabetes rats,reduced the production of MDA and remarkably improved the activity of GSH|Px in liver mitochondria.So insulin can improve lipid,protein and radical metabolic function and prevent injury from oxidation of the liver and body in diabetes rats.