RGS12 represses oral squamous cell carcinoma by driving M1 polarization of tumor-associated macrophages via controlling ciliary MYCBP2/KIF2A signaling

[1]  D. Hanahan Hallmarks of Cancer: New Dimensions. , 2022, Cancer discovery.

[2]  G. Yuan,et al.  Macrophage RGS12 contributes to osteoarthritis pathogenesis through enhancing the ubiquitination , 2021, Genes & diseases.

[3]  G. Hajishengallis,et al.  RGS12 Drives Macrophage Activation and Osteoclastogenesis in Periodontitis , 2021, Journal of dental research.

[4]  S. Batra,et al.  Correction: Tumor microenvironment: an evil nexus promoting aggressive head and neck squamous cell carcinoma and avenue for targeted therapy , 2021, Signal Transduction and Targeted Therapy.

[5]  Jianguo Wang,et al.  Targeting tumor-associated macrophages to synergize tumor immunotherapy , 2021, Signal Transduction and Targeted Therapy.

[6]  K. Ishii,et al.  Primary Cilia in the Skin: Functions in Immunity and Therapeutic Potential , 2021, Frontiers in Cell and Developmental Biology.

[7]  S. Batra,et al.  Tumor microenvironment: an evil nexus promoting aggressive head and neck squamous cell carcinoma and avenue for targeted therapy , 2021, Signal Transduction and Targeted Therapy.

[8]  C. R. Leemans,et al.  Head and neck squamous cell carcinoma , 2020, Nature Reviews Disease Primers.

[9]  G. Yuan,et al.  RGS12 Represses Oral Cancer via the Phosphorylation and SUMOylation of PTEN , 2020, Journal of dental research.

[10]  G. Yuan,et al.  RGS12 Is a Novel Critical NF-κB Activator in Inflammatory Arthritis , 2020, iScience.

[11]  Q. Wei,et al.  The role of tumor-associated macrophages (TAMs) in tumor progression and relevant advance in targeted therapy , 2020, Acta pharmaceutica Sinica. B.

[12]  Marimuthu Citartan,et al.  Evaluating the Polarization of Tumor-Associated Macrophages Into M1 and M2 Phenotypes in Human Cancer Tissue: Technicalities and Challenges in Routine Clinical Practice , 2020, Frontiers in Oncology.

[13]  L. Galluzzi,et al.  Macrophages and Metabolism in the Tumor Microenvironment. , 2019, Cell metabolism.

[14]  J. Varner,et al.  Targeting Tumor-Associated Macrophages in Cancer. , 2019, Trends in immunology.

[15]  M. Masařík,et al.  Effect of tumor microenvironment on pathogenesis of the head and neck squamous cell carcinoma: a systematic review , 2019, Molecular Cancer.

[16]  E. Golemis,et al.  Ciliary signalling in cancer , 2018, Nature Reviews Cancer.

[17]  Megan Cully Cancer: Re-educating tumour-associated macrophages with nanoparticles , 2018, Nature Reviews Drug Discovery.

[18]  Dai Fukumura,et al.  Enhancing cancer immunotherapy using antiangiogenics: opportunities and challenges , 2018, Nature Reviews Clinical Oncology.

[19]  Ruud H. Brakenhoff,et al.  The molecular landscape of head and neck cancer , 2018, Nature Reviews Cancer.

[20]  K. Scholich,et al.  Myc binding protein 2 suppresses M2‐like phenotypes in macrophages during zymosan‐induced inflammation in mice , 2018, European journal of immunology.

[21]  Dong Woon Kim,et al.  Primary cilia modulate TLR4-mediated inflammatory responses in hippocampal neurons , 2017, Journal of Neuroinflammation.

[22]  Alberto Mantovani,et al.  Tumour-associated macrophages as treatment targets in oncology , 2017, Nature Reviews Clinical Oncology.

[23]  A. Merchant,et al.  Primary cilia are present on human blood and bone marrow cells and mediate Hedgehog signaling. , 2016, Experimental hematology.

[24]  D. Saunders,et al.  Regulation of primary cilia formation by the ubiquitin-proteasome system. , 2016, Biochemical Society transactions.

[25]  Florian Klemm,et al.  Microenvironmental regulation of therapeutic response in cancer. , 2015, Trends in cell biology.

[26]  P. Codogno,et al.  Autophagy and regulation of cilia function and assembly , 2014, Cell Death and Differentiation.

[27]  D. Quail,et al.  Microenvironmental regulation of tumor progression and metastasis , 2014 .

[28]  M. Majesky,et al.  Regulator of G-Protein Signaling – 5 (RGS5) Is a Novel Repressor of Hedgehog Signaling , 2013, PloS one.

[29]  C. Lewis,et al.  Macrophage regulation of tumor responses to anticancer therapies. , 2013, Cancer cell.

[30]  Shuying Yang,et al.  Mx1‐Cre mediated Rgs12 conditional knockout mice exhibit increased bone mass phenotype , 2013, Genesis.

[31]  M. Sudol,et al.  Modularity and functional plasticity of scaffold proteins as p(l)acemakers in cell signaling. , 2012, Cellular signalling.

[32]  M. Knight,et al.  Primary cilia elongation in response to interleukin-1 mediates the inflammatory response , 2012, Cellular and Molecular Life Sciences.

[33]  R. Gijsbers,et al.  Regulator of G‐protein signaling 18 controls megakaryopoiesis and the cilia‐mediated vertebrate mechanosensory system , 2012, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[34]  E. Mohammadi,et al.  Barriers and facilitators related to the implementation of a physiological track and trigger system: A systematic review of the qualitative evidence , 2017, International journal for quality in health care : journal of the International Society for Quality in Health Care.

[35]  Y. Ohmori,et al.  Infiltration of M2 Tumor-Associated Macrophages in Oral Squamous Cell Carcinoma Correlates with Tumor Malignancy , 2011, Cancers.

[36]  Gypsyamber D'Souza,et al.  HPV-associated head and neck cancer: a virus-related cancer epidemic. , 2010, The Lancet. Oncology.

[37]  J. Paul,et al.  New Dimensions , 2011 .

[38]  H. Omran,et al.  When cilia go bad: cilia defects and ciliopathies , 2008, Nature Reviews Molecular Cell Biology.

[39]  H. Omran,et al.  When cilia go bad: cilia defects and ciliopathies , 2007, Nature Reviews Molecular Cell Biology.

[40]  A. Alavi,et al.  Opportunities and Challenges , 1998, In Vitro Diagnostic Industry in China.

[41]  A. Sica,et al.  Macrophage polarization comes of age. , 2005, Immunity.

[42]  D. Siderovski,et al.  Return of the GDI: the GoLoco motif in cell division. , 2004, Annual review of biochemistry.

[43]  S. Tickoo,et al.  Oral Cavity and Esophageal Carcinogenesis Modeled in Carcinogen-Treated Mice , 2004, Clinical Cancer Research.

[44]  G. Conner,et al.  Regulator of G-protein signaling protein 2 modulates purinergic calcium and ciliary beat frequency responses in airway epithelia. , 2002, American journal of respiratory cell and molecular biology.

[45]  J. Jordan,et al.  Tyrosine-kinase-dependent recruitment of RGS12 to the N-type calcium channel , 2000, Nature.

[46]  J. Hepler Emerging roles for RGS proteins in cell signalling. , 1999, Trends in pharmacological sciences.

[47]  R. Lefkowitz,et al.  GTPase Activating Specificity of RGS12 and Binding Specificity of an Alternatively Spliced PDZ (PSD-95/Dlg/ZO-1) Domain* , 1998, The Journal of Biological Chemistry.

[48]  S. Taylor Head and neck cancer. , 1991, Cancer chemotherapy and biological response modifiers.