Microbiomics, Metabolomics, Predicted Metagenomics, and Hepatic Steatosis in a Population‐Based Study of 1,355 Adults

Previous small studies have appraised the gut microbiome (GM) in steatosis, but large‐scale studies are lacking. We studied the association of the GM diversity and composition, plasma metabolites, predicted functional metagenomics, and steatosis.

[1]  A. Uitterlinden,et al.  Diversity, compositional and functional differences between gut microbiota of children and adults , 2020, Scientific Reports.

[2]  J. Lazarus,et al.  Burden of liver disease in Europe: Epidemiology and analysis of risk factors to identify prevention policies. , 2018, Journal of hepatology.

[3]  O. Franco,et al.  Association of dietary macronutrient composition and non-alcoholic fatty liver disease in an ageing population: the Rotterdam Study , 2018, Gut.

[4]  B. Neuschwander‐Tetri,et al.  Mechanisms of NAFLD development and therapeutic strategies , 2018, Nature Medicine.

[5]  P. Gentileschi,et al.  Molecular Phenomics and Metagenomics of Hepatic Steatosis in Non-Diabetic Obese Women , 2018, Nature Medicine.

[6]  Patrice D Cani Human gut microbiome: hopes, threats and promises , 2018, Gut.

[7]  Alexander E. Lopez,et al.  A Protein‐Truncating HSD17B13 Variant and Protection from Chronic Liver Disease , 2018, The New England journal of medicine.

[8]  E. Comelli,et al.  Nonalcoholic fatty liver disease is associated with dysbiosis independent of body mass index and insulin resistance , 2018, Scientific Reports.

[9]  O. Franco,et al.  The Rotterdam Study: 2018 update on objectives, design and main results , 2017, European Journal of Epidemiology.

[10]  Xun Xu,et al.  The gut microbiome in atherosclerotic cardiovascular disease , 2017, Nature Communications.

[11]  Jonathan C. Cohen,et al.  The PNPLA3 variant associated with fatty liver disease (I148M) accumulates on lipid droplets by evading ubiquitylation , 2017, Hepatology.

[12]  Ramnik J. Xavier,et al.  Human genetic variation and the gut microbiome in disease , 2017, Nature Reviews Genetics.

[13]  Ruixin Zhu,et al.  Suppressed hepatic bile acid signalling despite elevated production of primary and secondary bile acids in NAFLD , 2017, Gut.

[14]  S. Milstein,et al.  Acetyl CoA Carboxylase Inhibition Reduces Hepatic Steatosis but Elevates Plasma Triglycerides in Mice and Humans: A Bedside to Bench Investigation. , 2017, Cell metabolism.

[15]  S. Rashid,et al.  Protective effect of Chlorogenic acid against methotrexate induced oxidative stress, inflammation and apoptosis in rat liver: An experimental approach. , 2017, Chemico-biological interactions.

[16]  Shibu Yooseph,et al.  Gut Microbiome-Based Metagenomic Signature for Non-invasive Detection of Advanced Fibrosis in Human Nonalcoholic Fatty Liver Disease. , 2017, Cell metabolism.

[17]  P. Paci,et al.  Gut microbiota profiling of pediatric nonalcoholic fatty liver disease and obese patients unveiled by an integrated meta‐omics‐based approach , 2017, Hepatology.

[18]  T. Lehtimäki,et al.  Metabolic profiling of fatty liver in young and middle‐aged adults: Cross‐sectional and prospective analyses of the Young Finns Study , 2016, Hepatology.

[19]  S. Lynch,et al.  The Human Intestinal Microbiome in Health and Disease. , 2016, The New England journal of medicine.

[20]  A. Barritt,et al.  NAFLD and liver transplantation: Current burden and expected challenges. , 2016, Journal of hepatology.

[21]  Lanjuan Li,et al.  Altered Fecal Microbiota Correlates with Liver Biochemistry in Nonobese Patients with Non-alcoholic Fatty Liver Disease , 2016, Scientific Reports.

[22]  T. Vatanen,et al.  Dysbiosis, inflammation, and response to treatment: a longitudinal study of pediatric subjects with newly diagnosed inflammatory bowel disease , 2016, Genome Medicine.

[23]  Lawrence A. David,et al.  The severity of nonalcoholic fatty liver disease is associated with gut dysbiosis and shift in the metabolic function of the gut microbiota , 2016, Hepatology.

[24]  T. Dinan,et al.  Gut microbiota, obesity and diabetes , 2016, Postgraduate Medical Journal.

[25]  A. Hofman,et al.  Presence of diabetes mellitus and steatosis is associated with liver stiffness in a general population: The Rotterdam study , 2016, Hepatology.

[26]  Marcello Maida,et al.  The severity of steatosis influences liver stiffness measurement in patients with nonalcoholic fatty liver disease , 2015, Hepatology.

[27]  Fabian J Theis,et al.  Gender-specific pathway differences in the human serum metabolome , 2015, Metabolomics.

[28]  Tom R. Gaunt,et al.  Metabolite Profiling and Cardiovascular Event RiskCLINICAL PERSPECTIVE , 2015 .

[29]  Jing Li,et al.  Dysbiosis gut microbiota associated with inflammation and impaired mucosal immune function in intestine of humans with non-alcoholic fatty liver disease , 2015, Scientific Reports.

[30]  N. Reo,et al.  Altered gut microbial energy and metabolism in children with non-alcoholic fatty liver disease. , 2015, FEMS microbiology ecology.

[31]  Anne Tybjærg-Hansen,et al.  Exome-wide association study identifies a TM6SF2 variant that confers susceptibility to nonalcoholic fatty liver disease , 2014, Nature Genetics.

[32]  Lawrence A. David,et al.  Diet rapidly and reproducibly alters the human gut microbiome , 2013, Nature.

[33]  P. Bork,et al.  Richness of human gut microbiome correlates with metabolic markers , 2013, Nature.

[34]  Jesse R. Zaneveld,et al.  Predictive functional profiling of microbial communities using 16S rRNA marker gene sequences , 2013, Nature Biotechnology.

[35]  Masoumeh Sikaroodi,et al.  Fecal microbiome and volatile organic compound metabolome in obese humans with nonalcoholic fatty liver disease. , 2013, Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association.

[36]  E. Comelli,et al.  Intestinal microbiota in patients with nonalcoholic fatty liver disease , 2013, Hepatology.

[37]  Lixin Zhu,et al.  Characterization of gut microbiomes in nonalcoholic steatohepatitis (NASH) patients: A connection between endogenous alcohol and NASH , 2013, Hepatology.

[38]  A. Hofman,et al.  Prevalence and risk factors of non-alcoholic fatty liver disease in the elderly: results from the Rotterdam study. , 2012, Journal of hepatology.

[39]  S. Rabot,et al.  Intestinal microbiota determines development of non-alcoholic fatty liver disease in mice , 2012, Gut.

[40]  Nicholas A. Bokulich,et al.  Quality-filtering vastly improves diversity estimates from Illumina amplicon sequencing , 2012, Nature Methods.

[41]  G. Davey Smith,et al.  Supplementary Tables , 2009 .

[42]  A. McCullough,et al.  Validity of real time ultrasound in the diagnosis of hepatic steatosis: a prospective study. , 2009, Journal of hepatology.

[43]  Reino Laatikainen,et al.  High-throughput serum NMR metabonomics for cost-effective holistic studies on systemic metabolism. , 2009, The Analyst.

[44]  M. Domingo,et al.  Ruminococcus gauvreauii sp. nov., a glycopeptide-resistant species isolated from a human faecal specimen. , 2008, International journal of systematic and evolutionary microbiology.

[45]  Yuichi Harano,et al.  The Severity of Ultrasonographic Findings in Nonalcoholic Fatty Liver Disease Reflects the Metabolic Syndrome and Visceral Fat Accumulation , 2007, The American Journal of Gastroenterology.

[46]  J. Tiedje,et al.  Naïve Bayesian Classifier for Rapid Assignment of rRNA Sequences into the New Bacterial Taxonomy , 2007, Applied and Environmental Microbiology.

[47]  E. Mardis,et al.  An obesity-associated gut microbiome with increased capacity for energy harvest , 2006, Nature.

[48]  R. Loomba,et al.  Emerging Role of the Gut Microbiome in Nonalcoholic Fatty Liver Disease: From Composition to Function , 2019, Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association.

[49]  M. Connelly,et al.  Higher plasma GlycA, a novel pro-inflammatory glycoprotein biomarker, is associated with reduced life expectancy: The PREVEND study. , 2019, Clinica chimica acta; international journal of clinical chemistry.

[50]  R. Tibshirani Regression Shrinkage and Selection via the Lasso , 1996 .