Nanoparticles for inhibition of in vitro tumour angiogenesis: synergistic actions of ligand function and laser irradiation.

Careful design of nanoparticles plays a crucial role in their biomedical applications. It not only defines the stability of nanoparticles in a biological medium but also programs their biological functionality and specific interactions with cells. Here, an inorganic nanoparticulate system engineered to have a dual role as anti-angiogenic and hyperthermic agent is presented. The inorganic rod-shaped core is designed to strongly absorb near-infrared laser irradiation through the surface plasmon resonance and convert it into localized heat, while a peptide coating acts as an anti-angiogenic drug, altogether inhibiting vascular growth. The synergistic dual action provides an improved inhibition of the in vitro tumour angiogenesis, offering new possibilities for the development of nano-engineered anti-angiogenic drugs for therapies.

[1]  Ming-Fong Tsai,et al.  Au nanorod design as light-absorber in the first and second biological near-infrared windows for in vivo photothermal therapy. , 2013, ACS nano.

[2]  P. Carmeliet,et al.  Angiogenesis in cancer and other diseases , 2000, Nature.

[3]  Ruixia Chen,et al.  Combined near-IR photothermal therapy and chemotherapy using gold-nanorod/chitosan hybrid nanospheres to enhance the antitumor effect. , 2013, Biomaterials science.

[4]  Igor L. Medintz,et al.  Functionalizing nanoparticles with biological molecules: developing chemistries that facilitate nanotechnology. , 2013, Chemical reviews.

[5]  Napoleone Ferrara,et al.  Angiogenesis as a therapeutic target , 2005, Nature.

[6]  E. Robbins,et al.  Differential temperature sensitivity of normal and cancer cells in culture , 1970, Journal of cellular physiology.

[7]  S. Nitti,et al.  Exocytosis of peptide functionalized gold nanoparticles in endothelial cells. , 2012, Nanoscale.

[8]  Xingde Li,et al.  A quantitative study on the photothermal effect of immuno gold nanocages targeted to breast cancer cells. , 2008, ACS nano.

[9]  D. Vanhecke,et al.  Quantification of gold nanoparticle cell uptake under controlled biological conditions and adequate resolution. , 2014, Nanomedicine.

[10]  H. Dvorak,et al.  Concordant release of glycolysis proteins into the plasma preceding a diagnosis of ER+ breast cancer. , 2012, Cancer research.

[11]  Srirang Manohar,et al.  Light interactions with gold nanorods and cells: implications for photothermal nanotherapeutics. , 2011, Nano letters.

[12]  Otto L Muskens,et al.  Interactions of human endothelial cells with gold nanoparticles of different morphologies. , 2012, Small.

[13]  Peter Carmeliet,et al.  Angiogenesis in life, disease and medicine , 2005, Nature.

[14]  Tom Brown,et al.  Gold nanoparticles and fluorescently-labelled DNA as a platform for biological sensing. , 2013, Nanoscale.

[15]  Xin Cai,et al.  Comparison study of gold nanohexapods, nanorods, and nanocages for photothermal cancer treatment. , 2013, ACS nano.

[16]  Y. Sawaji,et al.  Anti-angiogenic action of hyperthermia by suppressing gene expression and production of tumour-derived vascular endothelial growth factor in vivo and in vitro , 2002, British Journal of Cancer.

[17]  Véronique Préat,et al.  To exploit the tumor microenvironment: Passive and active tumor targeting of nanocarriers for anti-cancer drug delivery. , 2010, Journal of controlled release : official journal of the Controlled Release Society.

[18]  K. Brand,et al.  Hyperthermia decreases cytokine-mediated adhesion molecule expression on human umbilical vein endothelial cells. , 1996, International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group.

[19]  Xiaohua Huang,et al.  Gold nanorods carrying paclitaxel for photothermal-chemotherapy of cancer. , 2013, Bioconjugate chemistry.

[20]  P. Wong,et al.  Mapping Photothermally Induced Gene Expression in Living Cells and Tissues by Nanorod-Locked Nucleic Acid Complexes , 2014, ACS Nano.

[21]  C. Pedone,et al.  Peptide‐based Molecules in Angiogenesis , 2006, Chemical biology & drug design.

[22]  Otto L Muskens,et al.  Laser-induced damage and recovery of plasmonically targeted human endothelial cells. , 2011, Nano letters.

[23]  Napoleone Ferrara,et al.  Vascular endothelial growth factor: basic science and clinical progress. , 2004, Endocrine reviews.

[24]  J. Folkman.  Role of angiogenesis in tumor growth and metastasis. , 2002, Seminars in oncology.

[25]  Shiladitya Sengupta,et al.  Nanotechnology-mediated targeting of tumor angiogenesis , 2011, Vascular cell.

[26]  W. Leenders,et al.  Targeted therapies of cancer: angiogenesis inhibition seems not enough. , 2010, Cancer letters.

[27]  Activator Inhibitor 1-dependent Mechanism Hyperthermia Inhibits Angiogenesis by a Plasminogen Updated , 2003 .

[28]  M. Roizen,et al.  Hallmarks of Cancer: The Next Generation , 2012 .

[29]  Rizia Bardhan,et al.  Emerging advances in nanomedicine with engineered gold nanostructures. , 2014, Nanoscale.

[30]  Jeffrey W. Clark,et al.  Lessons from phase III clinical trials on anti-VEGF therapy for cancer , 2006, Nature Clinical Practice Oncology.

[31]  Shay Soker,et al.  Neuropilin-1 Is Expressed by Endothelial and Tumor Cells as an Isoform-Specific Receptor for Vascular Endothelial Growth Factor , 1998, Cell.

[32]  K. Yoncheva,et al.  Antiangiogenic anticancer strategy based on nanoparticulate systems , 2011, Expert opinion on drug delivery.

[33]  Ling Wang,et al.  Antiangiogenic Properties of Gold Nanoparticles , 2005, Clinical Cancer Research.

[34]  D. Mukhopadhyay,et al.  Pro‐angiogenic Properties of Europium(III) Hydroxide Nanorods , 2008 .

[35]  Priyabrata Mukherjee,et al.  Biological properties of "naked" metal nanoparticles. , 2008, Advanced drug delivery reviews.

[36]  Mostafa A. El-Sayed,et al.  Preparation and Growth Mechanism of Gold Nanorods (NRs) Using Seed-Mediated Growth Method , 2003 .

[37]  Otto L Muskens,et al.  Manipulation of in vitro angiogenesis using peptide-coated gold nanoparticles. , 2013, ACS nano.

[38]  Victor K. Pustovalov,et al.  Thermo-optical analysis and selection of the properties of absorbing nanoparticles for laser applications in cancer nanotechnology , 2010, Cancer nanotechnology.

[39]  Zhi-nan Chen,et al.  Human Tumor Cells Induce Angiogenesis through Positive Feedback between CD147 and Insulin-Like Growth Factor-I , 2012, PloS one.

[40]  Long Wang,et al.  Win-Stay-Lose-Learn Promotes Cooperation in the Spatial Prisoner's Dilemma Game , 2012, PloS one.

[41]  Ilya Shmulevich,et al.  Robust quantification of in vitro angiogenesis through image analysis , 2005, IEEE Transactions on Medical Imaging.

[42]  Antonios G. Kanaras,et al.  Controlling the three-dimensional morphology of nanocrystals , 2010 .

[43]  Yihai Cao,et al.  It's hard to keep all things angiogenic in one JAR! , 2011, Vascular cell.

[44]  Vincent W. Li,et al.  Cancer prevention by targeting angiogenesis , 2012, Nature Reviews Clinical Oncology.

[45]  Dorota Bartczak,et al.  Receptor-mediated interactions between colloidal gold nanoparticles and human umbilical vein endothelial cells. , 2011, Small.

[46]  S. Emelianov,et al.  Multifunctional nanoscale strategies for enhancing and monitoring blood vessel regeneration. , 2012, Nano today.