Endocrine Cells of the Fetal Bronchus , and Other Neuroendocrine Cells Express the Leu-7 Antigenic Determinant Present on Natural Killer Cells

Small cell lung cancer is distinguished from other lung cancer histologic types by possessing a variety of neuroendocrine properties. Anti-Leu-7 is a monoclonal antibody that recognizes a 1 1 0.000-dalton molecular weight glycoprotein initially described on natural killer cells and subsequently reported on a variety of normal and malignant neural and neuroendocrine cell types. We have found intense anti-Leu-7 binding to a large number of small cell lung cancers. while other lung cancer types were negative or showed only weak and focal binding. Other antigens expressed by natural killer cells. lymphocytes. and mono-

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