Buccal penetration enhancement properties of N-trimethyl chitosan: Influence of quaternization degree on absorption of a high molecular weight molecule.

[1]  D. Monti,et al.  Effects of different N-trimethyl chitosans on in vitro/in vivo ofloxacin transcorneal permeation. , 2004, Journal of pharmaceutical sciences.

[2]  H E Junginger,et al.  Trimethylated chitosan as polymeric absorption enhancer for improved peroral delivery of peptide drugs. , 2004, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

[3]  S. Rossi,et al.  Assessment of chitosan derivatives as buccal and vaginal penetration enhancers. , 2004, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

[4]  P. Tengamnuay,et al.  Enhancing effect of chitosan on nasal absorption of salmon calcitonin in rats: comparison with hydroxypropyl- and dimethyl-beta-cyclodextrins. , 2003, International journal of pharmaceutics.

[5]  Stephan Reichl,et al.  The use of a porcine organotypic cornea construct for permeation studies from formulations containing befunolol hydrochloride. , 2003, International journal of pharmaceutics.

[6]  J. Hamman,et al.  N-Trimethyl Chitosan Chloride: Optimum Degree of Quaternization for Drug Absorption Enhancement Across Epithelial Cells , 2003, Drug development and industrial pharmacy.

[7]  J. Hamman,et al.  Evaluation of the Mucoadhesive Properties of N-Trimethyl Chitosan Chloride , 2003, Drug development and industrial pharmacy.

[8]  S. Rossi,et al.  Buccal Delivery of Acyclovir from Films Based on Chitosan and Polyacrylic Acid , 2003, Pharmaceutical development and technology.

[9]  J. Hamman,et al.  Intestinal paracellular permeation enhancement with quaternised chitosan: in situ and in vitro evaluation. , 2002, International journal of pharmaceutics.

[10]  D. L. Munday,et al.  Development and evaluation of a biphasic buccal adhesive tablet for nicotine replacement therapy. , 2002, International journal of pharmaceutics.

[11]  J. Hamman,et al.  Effect of the degree of quaternisation of N-trimethyl chitosan chloride on absorption enhancement: in vivo evaluation in rat nasal epithelia. , 2002, International journal of pharmaceutics.

[12]  Atilla Abidin or A. Hincal,et al.  Drug permeation enhancement via buccal route: possibilities and limitations. , 2001, Journal of controlled release : official journal of the Controlled Release Society.

[13]  F. X. Yu,et al.  Corneal epithelial tight junctions and their response to lipopolysaccharide challenge. , 2000, Investigative ophthalmology & visual science.

[14]  P. Wertz,et al.  Enhancing effect of chitosan on peptide drug delivery across buccal mucosa. , 2000, Biomaterials.

[15]  T. Kissel,et al.  Evaluation of absorption enhancement for a potent cyclopeptidic ανβ3-antagonist in a human intestinal cell line (Caco-2) , 2000 .

[16]  S. S. Davis.  Drug delivery systems , 2000 .

[17]  V. Dodane,et al.  Effect of chitosan on epithelial permeability and structure. , 1999, International journal of pharmaceutics.

[18]  H. Junginger,et al.  Enhancement of paracellular drug transport with highly quaternized N-trimethyl chitosan chloride in neutral environments: in vitro evaluation in intestinal epithelial cells (Caco-2). , 1999, Journal of pharmaceutical sciences.

[19]  J. Brussee,et al.  Preparation and NMR characterization of highly substitutedN-trimethyl chitosan chloride , 1998 .

[20]  H. Junginger,et al.  Comparison of the effect of different chitosan salts and N-trimethyl chitosan chloride on the permeability of intestinal epithelial cells (Caco-2). , 1998, Journal of controlled release : official journal of the Controlled Release Society.

[21]  H. Junginger,et al.  N-Trimethyl Chitosan Chloride as a Potential Absorption Enhancer Across Mucosal Surfaces: In Vitro Evaluation in Intestinal Epithelial Cells (Caco-2) , 1997, Pharmaceutical Research.

[22]  S. Rossi,et al.  Technological induction of mucoadhesive properties on waxy starches by grinding , 1997 .

[23]  G. Smistad,et al.  Bioadhesion of hydrated chitosans: An in vitro and in vivo study , 1996 .

[24]  Lisbeth Illum,et al.  Effect of Chitosan on the Permeability of Monolayers of Intestinal Epithelial Cells (Caco-2) , 1994, Pharmaceutical Research.

[25]  Y. Chien.  Novel Drug Delivery Systems , 1991 .

[26]  S. Rossi,et al.  Development of films and matrices based on chitosan and polyacrylic acid for vaginal delivery of acyclovir , 2003 .

[27]  A. Shojaei.  Buccal mucosa as a route for systemic drug delivery: a review. , 1998, Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques.

[28]  M. Aulton,et al.  Comparative Rheomechanical and Adhesive Properties of Two Hydrocolloid Dressings: Dependence on the Degree of Hydration , 1996 .

[29]  Y. Chien,et al.  Systemic delivery of peptides and proteins across absorptive mucosae. , 1996, Critical reviews in therapeutic drug carrier systems.

[30]  J. Robinson,et al.  Drug delivery via the mucous membranes of the oral cavity. , 1992, Journal of pharmaceutical sciences.

[31]  Claus-Michael Lehr,et al.  In vitro evaluation of mucoadhesive properties of chitosan and some other natural polymers , 1992 .