Widespread Trichophyton rubrum granulomas treated with griseofulvin.

Introduction Granulomatous cutaneous infections due to species of Trichophyton fungi were described by Majocchi 15 75 years ago. Since then similar cases have sporadically been reported (for review of literature see References 2, 3, 9, 10, 10a, 23). The pathogenesis of these infections is puzzling, for the fungal mycelia are seen deep in the moist living tissue in contrast to their usual localization to nonliving keratinized structures. This case report of an unusually extensive granulomatous infection with Trichophyton rubrum represents the first such case treated with griseofulvin. 4,6 The response to griseofulvin, as well as the results of certain new laboratory procedures, gives new insight into the probable mechanism of this uncommon disease. Report of a Case A 27-year-old white male draftsman was admitted to Jackson Memorial Hospital on Dec. 3, 1957, and discharged on April 2, 1959. Present Illness.— The patient developed multiple tender, hot, and painful joints several