Spectrophotometric Determination of Drugs and Pharmaceuticals by Cerium ( IV ) Amaranth Dye Couple

Simple, sensitive, accurate, and precise spectrophotometric methods for quantitative determination of drugs, viz., Darifenacin (DAR), Esmolol Hydrochloride (ESM), Montelukast Sodium (MON), Sildenafil citrate (SIL),Terbinafine (TER) and Tramadol Hydrochloride (TRA) were developed. The method of each drug depends upon oxidation of drugs by Ce (IV) (Excess) and estimating the amount of unreacted Ce (IV) by amaranth dye at 523nm. The calibration curves obeyed Beer’s law over the concentration range of 1.4-7.0 μg ml (DAR), 2-14 μg ml (ESM), 2-10 μg ml (MON), 20-70 μg ml (SIL), 3-21 μg ml (TER) & 2-14 μg ml (TRA). The methods have been validated in terms of guidelines of ICH and applied to analysis of pharmaceuticals.

[1]  K. Mukkanti,et al.  Development and validation of RP-UPLC method for the determination of darifenacin hydrobromide, its related compounds and its degradation products using design of experiments. , 2012, Journal of pharmaceutical and biomedical analysis.

[2]  R. M. Bankar,et al.  Spectrophotometric Determination Of Montelukast Sodium And Desloratadine In Combined Dosage Form , 2013 .

[3]  Lin Li-qin.  HPLC determination of montelukast sodium tablets and its related substances , 2013 .

[4]  K. B. Vinay,et al.  Sensitive spectrophotometric determination of tramadol hydrochloride in pharmaceuticals using Folin-Ciocalteu's reagent. , 2013 .

[5]  R. C. Luz,et al.  Determination of sildenafil citrate (Viagra®) in various pharmaceutical formulations by flow injection analysis with multiple pulse amperometric detection , 2012 .

[6]  U. Viplava Prasad,et al.  Three Simple Spectrometric Determination of Terbinafine Hydrochloride (TRB) in Pure State and Tablets , 2012 .

[7]  G. Venkateshwarlu,et al.  Extractive spectrophotometric methods for determination of terbinafine hydrochloride in pharmaceutical formulations using some acidic triphenylmethane dyes , 2012 .

[8]  A. Elbashir,et al.  Spectrophotometric Method For The Determination Of Ofloxacin And Levofloxacin In Pharmaceutical Formulations , 2012 .

[9]  Xu Airen.  Determination of Terbinafine in Human Plasma by RP-HPLC , 2012 .

[10]  Ramach,et al.  Spectrophotometric determination of montelukast sodium in bulk and pharmaceutical formulations , 2012 .

[11]  Chen Xiao-hui.  Determination of tertinafine hydrochloride content in functional cosmetics by high performance liquid chromatography , 2012 .

[12]  Ravindra Kumar,et al.  New stability indicating RP-UFLC method for determination of darifenacin hydrobromide in extended release tablet dosage form , 2012 .

[13]  F. Kobarfard,et al.  Application of Narrow-Bore HPLC Columns in Rapid Determination of Sildenafil Citrate in Its Pharmaceutical Dosage Forms , 2012, Iranian journal of pharmaceutical research : IJPR.

[14]  G. Mohamed,et al.  Utility of Ion-associate Formation Reactions for the Spectrophotometric Determination of Sildenafil Citrate in Pure form and in Virecta Tablets , 2011 .

[15]  S. Khalil,et al.  Analytical utility of atomic emission spectrometry for the determination of sildenafil citrate (Viagra) in pharmaceutical formulations , 2011 .

[16]  elwal,et al.  UV spectrophotometric determination of Darifenacin Hydrobromide in bulk and pharmaceutical dosage forms , 2011 .

[17]  K. PatelNilam,et al.  Spectrophotometric Determination of Montelukast Sodium and Levocetirizine Dihydrochloride in Tablet Dosage Form by AUC Curve Method , 2011 .

[18]  A. Rao,et al.  DEVELOPMENT AND VALIDATION OF RP-HPLC METHOD FOR THE DETERMINATION OF MONTELUKAST SODIUM IN BULK AND IN PHARMACEUTICAL FORMULATION , 2011 .

[19]  K. Vadivel,et al.  Quantitative spectrophotometric determination of sildenafil citrate in tablet formulation using urea as hydrotropic solubilizing agent , 2011 .

[20]  N. A. Ghalwa,et al.  Potentiometric Sensor for Determination of Tramadol Hydrochloride in Pharmaceutical Preparations and Biological Fluids , 2010 .

[21]  G. Saibabu,et al.  Extractive spectrophotometric methods for the determination of darifenacin , 2010 .

[22]  Zhu Xujiang.  Determination of Sildenafil Citrate Illegally Mixed into Jinsuo Gujing Pills by LC-MS , 2010 .

[23]  G. Saibabu,et al.  Visible spectrophotometric methods for the determination of darifenacin , 2010 .

[24]  A. Jyothi,et al.  Spectrophotometric methods for the determination of darifenacin , 2010 .

[25]  R. Sawant,et al.  Validated spectrophotometric methods for simultaneous estimation of Paracetamol, Domperidone and Tramadol HCl in pure and tablet dosage form , 2010 .

[26]  F. Regan,et al.  Determination of montelukast sodium by capillary electrophoresis. , 2008, Journal of separation science.

[27]  H. Chao.  Determination of Tramadol Hydrochloride and Its Tablets by Conductometric Titration , 2006 .

[28]  E. Gadkariem,et al.  Voltammetric determination of montelukast sodium in dosage forms and human plasma. , 2005, Farmaco.

[29]  Y. Kadioglu,et al.  Determination of tramadol hydrochloride in ampoule dosage forms by using UV spectrophotometric and HPLC-DAD methods in methanol and water media. , 2005, Farmaco.

[30]  F. Peters,et al.  Screening for library-assisted identification and fully validated quantification of 22 beta-blockers in blood plasma by liquid chromatography-mass spectrometry with atmospheric pressure chemical ionization. , 2004, Journal of chromatography. A.

[31]  S. Zeng,et al.  Simultaneous determination of the enantiomers of esmolol and its acid metabolite in human plasma by reversed phase liquid chromatography with solid-phase extraction. , 2004, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

[32]  S. Zeng,et al.  Stereoselective RP-HPLC determination of esmolol enantiomers in human plasma after pre-column derivatization. , 2004, Journal of biochemical and biophysical methods.

[33]  A. Zuppa,et al.  Liquid chromatography-electrospray mass spectrometry (LC-MS) method for determination of esmolol concentration in human plasma. , 2003, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

[34]  Yongjun Wu,et al.  [HPLC method for determination of tramadol hydrochloride in human plasma]. , 2003, Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition.

[35]  Chandini R. Nayar.  HPTLC Method for determination of Terbinafine in the Bulk drug and Tablet dosage form , 2003 .

[36]  J. Havel,et al.  Determination of esmolol in serum by capillary zone electrophoresis and its monitoring in course of heart surgery. , 2001, Journal of chromatography. B, Biomedical sciences and applications.

[37]  D. Drissel,et al.  Liquid-chromatographic analysis for esmolol and its major metabolite in urine. , 1986, Clinical chemistry.