Neuropathology and biochemistry of Aβ and its aggregates in Alzheimer’s disease

[1]  H. Soininen,et al.  Alzheimer’s disease-related plaques in nondemented subjects , 2014, Alzheimer's & Dementia.

[2]  S. Prusiner,et al.  Serial propagation of distinct strains of Aβ prions from Alzheimer’s disease patients , 2014, Proceedings of the National Academy of Sciences.

[3]  S. Prusiner,et al.  Distinct synthetic Aβ prion strains producing different amyloid deposits in bigenic mice , 2014, Proceedings of the National Academy of Sciences.

[4]  E. Mandelkow,et al.  Stages and Conformations of the Tau Repeat Domain during Aggregation and Its Effect on Neuronal Toxicity* , 2014, The Journal of Biological Chemistry.

[5]  Oliver Wirths,et al.  Focusing the amyloid cascade hypothesis on N-truncated Abeta peptides as drug targets against Alzheimer’s disease , 2014, Acta Neuropathologica.

[6]  Martin Hallbeck,et al.  Spreading of amyloid-β peptides via neuritic cell-to-cell transfer is dependent on insufficient cellular clearance , 2014, Neurobiology of Disease.

[7]  S. Becker,et al.  Turn plasticity distinguishes different modes of amyloid-β aggregation. , 2014, Journal of the American Chemical Society.

[8]  C. V. von Arnim,et al.  Biochemical stages of amyloid-β peptide aggregation and accumulation in the human brain and their association with symptomatic and pathologically preclinical Alzheimer's disease. , 2014, Brain : a journal of neurology.

[9]  M. Staufenbiel,et al.  The type of Aβ-related neuronal degeneration differs between amyloid precursor protein (APP23) and amyloid β-peptide (APP48) transgenic mice , 2013, Acta neuropathologica communications.

[10]  K. Nilsson,et al.  Seeded strain‐like transmission of β‐amyloid morphotypes in APP transgenic mice , 2013, EMBO reports.

[11]  J. Walter,et al.  Cross-talk of membrane lipids and Alzheimer-related proteins , 2013, Molecular Neurodegeneration.

[12]  R O Weller,et al.  Review: Cerebral amyloid angiopathy, prion angiopathy, CADASIL and the spectrum of protein elimination failure angiopathies (PEFA) in neurodegenerative disease with a focus on therapy , 2013, Neuropathology and applied neurobiology.

[13]  A. Fagan,et al.  Preclinical Alzheimer's disease and its outcome: a longitudinal cohort study , 2013, The Lancet Neurology.

[14]  J. Attems,et al.  Pathology of clinical and preclinical Alzheimer’s disease , 2013, European Archives of Psychiatry and Clinical Neuroscience.

[15]  F. Heppner,et al.  Microglia actions in Alzheimer’s disease , 2013, Acta Neuropathologica.

[16]  Charles D. Schwieters,et al.  Molecular Structure of β-Amyloid Fibrils in Alzheimer’s Disease Brain Tissue , 2013, Cell.

[17]  F. Heppner,et al.  Microglia as Dynamic and Essential Components of the Amyloid Hypothesis , 2013, Neuron.

[18]  David A Bennett,et al.  Brain amyloid-β oligomers in ageing and Alzheimer's disease. , 2013, Brain : a journal of neurology.

[19]  T. Bayer,et al.  Early intraneuronal accumulation and increased aggregation of phosphorylated Abeta in a mouse model of Alzheimer’s disease , 2013, Acta Neuropathologica.

[20]  Francis Eustache,et al.  Amyloid imaging in cognitively normal individuals, at-risk populations and preclinical Alzheimer's disease , 2013, NeuroImage: Clinical.

[21]  M. Staufenbiel,et al.  Dispersible amyloid β-protein oligomers, protofibrils, and fibrils represent diffusible but not soluble aggregates: their role in neurodegeneration in amyloid precursor protein (APP) transgenic mice , 2012, Neurobiology of Aging.

[22]  R. Tanzi The genetics of Alzheimer disease. , 2012, Cold Spring Harbor perspectives in medicine.

[23]  M. Fändrich,et al.  Oligomeric intermediates in amyloid formation: structure determination and mechanisms of toxicity. , 2012, Journal of molecular biology.

[24]  Ole A. Andreassen,et al.  A mutation in APP protects against Alzheimer’s disease and age-related cognitive decline , 2012, Nature.

[25]  C. Haass,et al.  Trafficking and proteolytic processing of APP. , 2012, Cold Spring Harbor perspectives in medicine.

[26]  David Eisenberg,et al.  Atomic View of a Toxic Amyloid Small Oligomer , 2012, Science.

[27]  K. Reymann,et al.  Structural basis of β-amyloid-dependent synaptic dysfunctions. , 2012, Angewandte Chemie.

[28]  M. Fändrich,et al.  High-molecular weight Aβ oligomers and protofibrils are the predominant Aβ species in the native soluble protein fraction of the AD brain , 2012, Journal of cellular and molecular medicine.

[29]  M. Siepmann,et al.  Phosphorylation of Amyloid-β Peptide at Serine 8 Attenuates Its Clearance via Insulin-degrading and Angiotensin-converting Enzymes* , 2012, The Journal of Biological Chemistry.

[30]  J. Schneider,et al.  National Institute on Aging–Alzheimer's Association guidelines for the neuropathologic assessment of Alzheimer's disease , 2012, Alzheimer's & Dementia.

[31]  M. Fändrich,et al.  Assembly of Alzheimer's Aβ peptide into nanostructured amyloid fibrils , 2011 .

[32]  E. Capetillo-Zarate,et al.  High-resolution 3D reconstruction reveals intra-synaptic amyloid fibrils. , 2011, The American journal of pathology.

[33]  Dietmar R. Thal,et al.  Stages of the Pathologic Process in Alzheimer Disease: Age Categories From 1 to 100 Years , 2011, Journal of neuropathology and experimental neurology.

[34]  F. Jessen,et al.  Nitration of Tyrosine 10 Critically Enhances Amyloid β Aggregation and Plaque Formation , 2011, Neuron.

[35]  K. Reymann,et al.  Selective Hippocampal Neurodegeneration in Transgenic Mice Expressing Small Amounts of Truncated Aβ Is Induced by Pyroglutamate–Aβ Formation , 2011, The Journal of Neuroscience.

[36]  M. Hoch,et al.  Extracellular phosphorylation of the amyloid β‐peptide promotes formation of toxic aggregates during the pathogenesis of Alzheimer's disease , 2011, The EMBO journal.

[37]  Nikolaus Grigorieff,et al.  Recent progress in understanding Alzheimer's β-amyloid structures. , 2011, Trends in biochemical sciences.

[38]  J. Morris,et al.  The diagnosis of dementia due to Alzheimer’s disease: Recommendations from the National Institute on Aging-Alzheimer’s Association workgroups on diagnostic guidelines for Alzheimer's disease , 2011, Alzheimer's & Dementia.

[39]  Denise C. Park,et al.  Toward defining the preclinical stages of Alzheimer’s disease: Recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease , 2011, Alzheimer's & Dementia.

[40]  E. Giralt,et al.  Aβ40 and Aβ42 amyloid fibrils exhibit distinct molecular recycling properties. , 2011, Journal of the American Chemical Society.

[41]  H. Scheidt,et al.  Solid-state NMR spectroscopic investigation of Aβ protofibrils: implication of a β-sheet remodeling upon maturation into terminal amyloid fibrils. , 2011, Angewandte Chemie.

[42]  Shinichiro Nakamura,et al.  Two Distinct Amyloid β-Protein (Aβ) Assembly Pathways Leading to Oligomers and Fibrils Identified by Combined Fluorescence Correlation Spectroscopy, Morphology, and Toxicity Analyses* , 2011, The Journal of Biological Chemistry.

[43]  C. Haass,et al.  Amyloid-β protein modulates the perivascular clearance of neuronal apolipoprotein E in mouse models of Alzheimer’s disease , 2011, Journal of Neural Transmission.

[44]  H. Kretzschmar,et al.  Multiple Events Lead to Dendritic Spine Loss in Triple Transgenic Alzheimer's Disease Mice , 2010, PloS one.

[45]  Frank Baumann,et al.  Peripherally Applied Aβ-Containing Inoculates Induce Cerebral β-Amyloidosis , 2010, Science.

[46]  A. Caflisch,et al.  Micelle-like architecture of the monomer ensemble of Alzheimer's amyloid-β peptide in aqueous solution and its implications for Aβ aggregation. , 2010, Journal of molecular biology.

[47]  A. Bush,et al.  Biological metals and Alzheimer's disease: Implications for therapeutics and diagnostics , 2010, Progress in Neurobiology.

[48]  E. Salmon,et al.  18F‐flutemetamol amyloid imaging in Alzheimer disease and mild cognitive impairment: A phase 2 trial , 2010, Annals of neurology.

[49]  Michael T. Lin,et al.  Co-occurrence of Alzheimer's disease β-amyloid and tau pathologies at synapses , 2010, Neurobiology of Aging.

[50]  D. Selkoe,et al.  The presence of sodium dodecyl sulphate-stable Abeta dimers is strongly associated with Alzheimer-type dementia. , 2010, Brain : a journal of neurology.

[51]  Judianne Davis,et al.  Structural conversion of neurotoxic amyloid-β(1–42) oligomers to fibrils , 2010, Nature Structural &Molecular Biology.

[52]  E. Capetillo-Zarate,et al.  Intraneuronal β-amyloid accumulation and synapse pathology in Alzheimer’s disease , 2010, Acta Neuropathologica.

[53]  K. Reymann,et al.  Mechanism of amyloid plaque formation suggests an intracellular basis of Aβ pathogenicity , 2010, Proceedings of the National Academy of Sciences.

[54]  N. Grigorieff,et al.  Nanoscale Flexibility Parameters of Alzheimer Amyloid Fibrils Determined by Electron Cryo-Microscopy** , 2010, Angewandte Chemie.

[55]  Tuomas P. J. Knowles,et al.  An Analytical Solution to the Kinetics of Breakable Filament Assembly , 2009, Science.

[56]  N. Grigorieff,et al.  Comparison of Alzheimer Aβ(1–40) and Aβ(1–42) amyloid fibrils reveals similar protofilament structures , 2009, Proceedings of the National Academy of Sciences.

[57]  F. Heppner,et al.  Formation and maintenance of Alzheimer's disease β-amyloid plaques in the absence of microglia , 2009, Nature Neuroscience.

[58]  Hans-Ulrich Demuth,et al.  Pyroglutamate formation influences solubility and amyloidogenicity of amyloid peptides. , 2009, Biochemistry.

[59]  T. Bayer,et al.  Intraneuronal pyroglutamate-Abeta 3–42 triggers neurodegeneration and lethal neurological deficits in a transgenic mouse model , 2009, Acta Neuropathologica.

[60]  N. Grigorieff,et al.  Structural polymorphism of Alzheimer Aβ and other amyloid fibrils , 2009, Prion.

[61]  D. Holtzman,et al.  Microglia Mediate the Clearance of Soluble Aβ through Fluid Phase Macropinocytosis , 2009, The Journal of Neuroscience.

[62]  N. Grigorieff,et al.  Abeta(1-40) fibril polymorphism implies diverse interaction patterns in amyloid fibrils. , 2009, Journal of molecular biology.

[63]  Scott A. Small,et al.  Linking Aβ and Tau in Late-Onset Alzheimer's Disease: A Dual Pathway Hypothesis , 2008, Neuron.

[64]  C. Masters,et al.  Amyloid-β Peptide (Aβ) Neurotoxicity Is Modulated by the Rate of Peptide Aggregation: Aβ Dimers and Trimers Correlate with Neurotoxicity , 2008, The Journal of Neuroscience.

[65]  C. Glabe,et al.  Structural Classification of Toxic Amyloid Oligomers* , 2008, Journal of Biological Chemistry.

[66]  Hans-Ulrich Demuth,et al.  Glutaminyl cyclase inhibition attenuates pyroglutamate Aβ and Alzheimer's disease–like pathology , 2008, Nature Medicine.

[67]  Shaomin Li,et al.  Amyloid-β protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memory , 2008, Nature Medicine.

[68]  N. Grigorieff,et al.  Paired β-sheet structure of an Aβ(1-40) amyloid fibril revealed by electron microscopy , 2008, Proceedings of the National Academy of Sciences.

[69]  S. Barghorn,et al.  Aβ-globulomers are formed independently of the fibril pathway , 2008, Neurobiology of Disease.

[70]  C. Rowe,et al.  Aβ deposits in older non-demented individuals with cognitive decline are indicative of preclinical Alzheimer's disease , 2008, Neuropsychologia.

[71]  R O Weller,et al.  Solutes, but not cells, drain from the brain parenchyma along basement membranes of capillaries and arteries: significance for cerebral amyloid angiopathy and neuroimmunology , 2008, Neuropathology and applied neurobiology.

[72]  F. LaFerla,et al.  Modeling behavioral and neuronal symptoms of Alzheimer's disease in mice: A role for intraneuronal amyloid , 2007, Neuroscience & Biobehavioral Reviews.

[73]  Y. Ishii,et al.  Evidence of fibril-like β-sheet structures in a neurotoxic amyloid intermediate of Alzheimer's β-amyloid , 2007, Nature Structural &Molecular Biology.

[74]  Walter Richter,et al.  Effect of different salt ions on the propensity of aggregation and on the structure of Alzheimer's abeta(1-40) amyloid fibrils. , 2007, Journal of molecular biology.

[75]  J. Cladera,et al.  Conversion of non-fibrillar beta-sheet oligomers into amyloid fibrils in Alzheimer's disease amyloid peptide aggregation. , 2007, Biochemical and biophysical research communications.

[76]  P. Scheltens,et al.  Research criteria for the diagnosis of Alzheimer's disease: revising the NINCDS–ADRDA criteria , 2007, The Lancet Neurology.

[77]  A. Aguzzi,et al.  Insights into prion strains and neurotoxicity , 2007, Nature Reviews Molecular Cell Biology.

[78]  D. Selkoe,et al.  Aβ Oligomers – a decade of discovery , 2007, Journal of neurochemistry.

[79]  R. Kayed,et al.  Small Molecule Inhibitors of Aggregation Indicate That Amyloid β Oligomerization and Fibrillization Pathways Are Independent and Distinct* , 2007, Journal of Biological Chemistry.

[80]  Bernardo L Sabatini,et al.  Natural Oligomers of the Alzheimer Amyloid-β Protein Induce Reversible Synapse Loss by Modulating an NMDA-Type Glutamate Receptor-Dependent Signaling Pathway , 2007, The Journal of Neuroscience.

[81]  D. Selkoe,et al.  Soluble protein oligomers in neurodegeneration: lessons from the Alzheimer's amyloid β-peptide , 2007, Nature Reviews Molecular Cell Biology.

[82]  D. Walsh,et al.  Exogenous Induction of Cerebral ß-Amyloidogenesis Is Governed by Agent and Host , 2006, Science.

[83]  Hans-Ulrich Demuth,et al.  On the seeding and oligomerization of pGlu-amyloid peptides (in vitro). , 2006, Biochemistry.

[84]  N. Grigorieff,et al.  Quaternary structure of a mature amyloid fibril from Alzheimer's Abeta(1-40) peptide. , 2006, Journal of molecular biology.

[85]  P. Verkade,et al.  Alzheimer's disease beta-amyloid peptides are released in association with exosomes. , 2006, Proceedings of the National Academy of Sciences of the United States of America.

[86]  M. Gallagher,et al.  A specific amyloid-β protein assembly in the brain impairs memory , 2006, Nature.

[87]  S. Hébert,et al.  The amyloid‐β precursor protein: integrating structure with biological function , 2005 .

[88]  P. Keller,et al.  Globular amyloid β‐peptide1−42 oligomer − a homogenous and stable neuropathological protein in Alzheimer's disease , 2005 .

[89]  P. T. Nguyen,et al.  Dendritic Spine Abnormalities in Amyloid Precursor Protein Transgenic Mice Demonstrated by Gene Transfer and Intravital Multiphoton Microscopy , 2005, The Journal of Neuroscience.

[90]  M. Fändrich,et al.  The aggregation kinetics of Alzheimer's β‐amyloid peptide is controlled by stochastic nucleation , 2005, Protein science : a publication of the Protein Society.

[91]  Jaime Grutzendler,et al.  Fibrillar amyloid deposition leads to local synaptic abnormalities and breakage of neuronal branches , 2004, Nature Neuroscience.

[92]  D. Selkoe,et al.  A Seed for Alzheimer Amyloid in the Brain , 2004, The Journal of Neuroscience.

[93]  P. Lansbury,et al.  Protofibrils, pores, fibrils, and neurodegeneration: separating the responsible protein aggregates from the innocent bystanders. , 2003, Annual review of neuroscience.

[94]  Richard Mayeux,et al.  The Genetics of Adult-Onset Neuropsychiatric Disease: Complexities and Conundra? , 2003, Science.

[95]  M. Staufenbiel,et al.  Extracellular amyloid formation and associated pathology in neural grafts , 2003, Nature Neuroscience.

[96]  P. Fraser,et al.  Alternate Aggregation Pathways of the Alzheimer β-Amyloid Peptide: Aβ Association Kinetics at Endosomal pH , 2003 .

[97]  Shigeo Murayama,et al.  Isoaspartate formation at position 23 of amyloid beta peptide enhanced fibril formation and deposited onto senile plaques and vascular amyloids in Alzheimer's disease , 2002, Journal of neuroscience research.

[98]  T. Miyakawa Vascular Pathology in Alzheimer's Disease , 2002, Annals of the New York Academy of Sciences.

[99]  Jia-Jia Liu,et al.  Microtubule-associated protein 1B , 2002, The Journal of cell biology.

[100]  H. Braak,et al.  Phases of Aβ-deposition in the human brain and its relevance for the development of AD , 2002, Neurology.

[101]  R. Mohs,et al.  Consortium to establish a registry for Alzheimer's disease (CERAD) clinical and neuropsychological assessment of Alzheimer's disease. , 2002, Psychopharmacology bulletin.

[102]  Oliver Wirths,et al.  Intraneuronal Aβ accumulation precedes plaque formation in β-amyloid precursor protein and presenilin-1 double-transgenic mice , 2001, Neuroscience Letters.

[103]  R. Terry Cell death or synaptic loss in Alzheimer disease. , 2000, Journal of neuropathology and experimental neurology.

[104]  H. Braak,et al.  Sequence of Aβ‐Protein Deposition in the Human Medial Temporal Lobe , 2000 .

[105]  S. Müller,et al.  Studies on the in Vitro Assembly of Aβ 1–40: Implications for the Search for Aβ Fibril Formation Inhibitors , 2000 .

[106]  A. Roher,et al.  Evidence for Seeding of β-Amyloid by Intracerebral Infusion of Alzheimer Brain Extracts in β-Amyloid Precursor Protein-Transgenic Mice , 2000, The Journal of Neuroscience.

[107]  B. Sommer,et al.  Neuronal overexpression of mutant amyloid precursor protein results in prominent deposition of cerebrovascular amyloid. , 1999, Proceedings of the National Academy of Sciences of the United States of America.

[108]  M. Frotscher,et al.  Cerebral Amyloid Induces Aberrant Axonal Sprouting and Ectopic Terminal Formation in Amyloid Precursor Protein Transgenic Mice , 1999, The Journal of Neuroscience.

[109]  T. Arendt,et al.  Progression of neurofibrillary changes and PHF-τ in end-stage Alzheimer’s disease is different from plaque and cortical microglial pathology , 1998, Neurobiology of Aging.

[110]  Yu-Min Kuo,et al.  Cerebral amyloid angiopathy: amyloid beta accumulates in putative interstitial fluid drainage pathways in Alzheimer's disease. , 1998, The American journal of pathology.

[111]  T. Morgan,et al.  Diffusible, nonfibrillar ligands derived from Abeta1-42 are potent central nervous system neurotoxins. , 1998, Proceedings of the National Academy of Sciences of the United States of America.

[112]  Y. Ihara,et al.  Astrocytes containing amyloid beta-protein (Abeta)-positive granules are associated with Abeta40-positive diffuse plaques in the aged human brain. , 1998, The American journal of pathology.

[113]  Y. Ihara,et al.  Diffuse plaques associated with astroglial amyloid β protein, possibly showing a disappearing stage of senile plaques , 1998, Acta Neuropathologica.

[114]  Dietmar R. Thal,et al.  Brain tissue damage and regeneration monitored by β‐amyloid precursor protein in experimental laser‐induced interstitial thermotherapy , 1998 .

[115]  J. Seelig,et al.  Interaction of Alzheimer beta-amyloid peptide(1-40) with lipid membranes. , 1997, Biochemistry.

[116]  D. Dickson,et al.  The Pathogenesis of Senile Plaques , 1997, Journal of neuropathology and experimental neurology.

[117]  J. Trojanowski,et al.  Full-length amyloid-beta (1-42(43)) and amino-terminally modified and truncated amyloid-beta 42(43) deposit in diffuse plaques. , 1996, The American journal of pathology.

[118]  D. Graham,et al.  Is β-APP a marker of axonal damage in short-surviving head injury? , 1996, Acta Neuropathologica.

[119]  T. Iwatsubo,et al.  Amino- and carboxyl-terminal heterogeneity of β-amyloid peptides deposited in human brain , 1996, Neuroscience Letters.

[120]  P. Mcgeer,et al.  Granules in glial cells of patients with Alzheimer's disease are immunopositive for C-terminal sequences of β-amyloid protein , 1996, Neuroscience Letters.

[121]  D. Selkoe,et al.  Sequence of Deposition of Heterogeneous Amyloid β-Peptides and APO E in Down Syndrome: Implications for Initial Events in Amyloid Plaque Formation , 1996, Neurobiology of Disease.

[122]  T A Gennarelli,et al.  The Nature, Distribution and Causes of Traumatic Brain Injury , 1995, Brain pathology.

[123]  D. Munoz,et al.  Qualitative and Quantitative Differences in Senile Plaque Dystrophie Neurites of Alzheimer's Disease and Normal Aged Brain , 1995, Journal of neuropathology and experimental neurology.

[124]  R. Mrak,et al.  Interleukin‐1 Expression in Different Plaque Types in Alzheimer's Disease: Significance in Plaque Evalution , 1995, Journal of neuropathology and experimental neurology.

[125]  D. Mann,et al.  Dominant and differential deposition of distinct β-amyloid peptide species, Aβ N3(pE), in senile plaques , 1995, Neuron.

[126]  T. Iwatsubo,et al.  Visualization of Aβ42(43) and Aβ40 in senile plaques with end-specific Aβ monoclonals: Evidence that an initially deposited species is Aβ42(43) , 1994, Neuron.

[127]  M J Ball,et al.  beta-Amyloid-(1-42) is a major component of cerebrovascular amyloid deposits: implications for the pathology of Alzheimer disease. , 1993, Proceedings of the National Academy of Sciences of the United States of America.

[128]  M J Ball,et al.  Structural alterations in the peptide backbone of beta-amyloid core protein may account for its deposition and stability in Alzheimer's disease. , 1993, The Journal of biological chemistry.

[129]  R. Kalaria,et al.  Accumulation of the beta amyloid precursor protein at sites of ischemic injury in rat brain. , 1993, Neuroreport.

[130]  Bradley T. Hyman,et al.  Distribution of Alzheimer‐type pathologic changes in nondemented elderly individuals matches the pattern in Alzheimer's disease , 1992, Neurology.

[131]  D. Selkoe,et al.  Mass spectrometry of purified amyloid beta protein in Alzheimer's disease. , 1992, The Journal of biological chemistry.

[132]  Bradley T. Hyman,et al.  Neurofibrillary tangles but not senile plaques parallel duration and severity of Alzheimer's disease , 1992, Neurology.

[133]  J. Vonsattel,et al.  Cerebral amyloid angiopathy without and with cerebral hemorrhages: A comparative histological study , 1991, Annals of neurology.

[134]  J. Price,et al.  The distribution of tangles, plaques and related immunohistochemical markers in healthy aging and Alzheimer's disease , 1991, Neurobiology of Aging.

[135]  S. M. Sumi,et al.  The Consortium to Establish a Registry for Alzheimer's Disease (CERAD) , 1991, Neurology.

[136]  S. DeKosky,et al.  Synapse loss in frontal cortex biopsies in Alzheimer's disease: Correlation with cognitive severity , 1990, Annals of neurology.

[137]  W. Griffin,et al.  Brain interleukin 1 and S-100 immunoreactivity are elevated in Down syndrome and Alzheimer disease. , 1989, Proceedings of the National Academy of Sciences of the United States of America.

[138]  D. Dickson,et al.  Alzheimer's disease. A double-labeling immunohistochemical study of senile plaques. , 1988, The American journal of pathology.

[139]  S. Mirra,et al.  Neuritic Plaque Amyloid in Alzheimer's Disease Is Highly Racemized , 1988, Journal of neurochemistry.

[140]  H. Wiśniewski,et al.  Microtubule-associated protein tau. A component of Alzheimer paired helical filaments. , 1986, The Journal of biological chemistry.

[141]  C. Masters,et al.  Amyloid plaque core protein in Alzheimer disease and Down syndrome. , 1985, Proceedings of the National Academy of Sciences of the United States of America.

[142]  G. Glenner,et al.  Alzheimer's disease: Initial report of the purification and characterization of a novel cerebrovascular amyloid protein , 1984 .

[143]  Michael Ewers,et al.  Spreading of amyloid, tau, and microvascular pathology in Alzheimer's disease: findings from neuropathological and neuroimaging studies. , 2014, Journal of Alzheimer's disease : JAD.

[144]  C. Schwieters,et al.  Molecular Structure of beta-Amyloid Fibrils in Alzheimer's Disease Brain Tissue. , 2013 .

[145]  Charles Duyckaerts,et al.  National Institute on Aging–Alzheimer’s Association guidelines for the neuropathologic assessment of Alzheimer’s disease: a practical approach , 2011, Acta Neuropathologica.

[146]  F. Heppner,et al.  Formation and maintenance of Alzheimer’s disease beta-amyloid plaques in the absence of microglia , 2010 .

[147]  J. Hardy,et al.  The Amyloid Hypothesis of Alzheimer ’ s Disease : Progress and Problems on the Road to Therapeutics , 2009 .

[148]  Michela Gallagher,et al.  A specific amyloid-beta protein assembly in the brain impairs memory. , 2006, Nature.

[149]  P. Keller,et al.  Globular amyloid beta-peptide oligomer - a homogenous and stable neuropathological protein in Alzheimer's disease. , 2005, Journal of neurochemistry.

[150]  S. Hébert,et al.  The amyloid-beta precursor protein: integrating structure with biological function. , 2005, The EMBO journal.

[151]  J. Zimmer,et al.  Microglial and astroglial reactions to anterograde axonal degeneration: a histochemical and immunocytochemical study of the adult rat fascia dentata after entorhinal perforant path lesions , 2004, Experimental Brain Research.

[152]  K. Solly,et al.  Migration of xenogenic astrocytes in myelinated tracts: a novel probe for immune responses in white matter , 2004, Acta Neuropathologica.

[153]  P. Fraser,et al.  Alternate aggregation pathways of the Alzheimer beta-amyloid peptide: Abeta association kinetics at endosomal pH. , 2003, Journal of molecular biology.

[154]  T. Wyss-Coray,et al.  Adult mouse astrocytes degrade amyloid-beta in vitro and in situ. , 2003, Nature medicine.

[155]  N. Milton Phosphorylation of amyloid-beta at the serine 26 residue by human cdc2 kinase. , 2001, Neuroreport.

[156]  T. Bayer,et al.  Intraneuronal Abeta accumulation precedes plaque formation in beta-amyloid precursor protein and presenilin-1 double-transgenic mice. , 2001, Neuroscience letters.

[157]  A. Roher,et al.  Evidence for seeding of beta -amyloid by intracerebral infusion of Alzheimer brain extracts in beta -amyloid precursor protein-transgenic mice. , 2000, The Journal of neuroscience : the official journal of the Society for Neuroscience.

[158]  P. Greengard,et al.  Intraneuronal Abeta42 accumulation in human brain. , 2000, The American journal of pathology.

[159]  S. Müller,et al.  Studies on the in vitro assembly of a beta 1-40: implications for the search for a beta fibril formation inhibitors. , 2000, Journal of structural biology.

[160]  H. Braak,et al.  Sequence of Abeta-protein deposition in the human medial temporal lobe. , 2000, Journal of neuropathology and experimental neurology.

[161]  P. Greengard,et al.  Intraneuronal Aβ42 Accumulation in Human Brain , 2000 .

[162]  R O Weller,et al.  Cerebral amyloid angiopathy: amyloid beta accumulates in putative interstitial fluid drainage pathways in Alzheimer's disease. , 1998, The American journal of pathology.

[163]  D. Thal,et al.  Stage-correlated distribution of type 1 and 2 dystrophic neurites in cortical and hippocampal plaques in Alzheimer's disease. , 1998, Journal fur Hirnforschung.

[164]  Charles M. Lieber,et al.  Observation of metastable Abeta amyloid protofibrils by atomic force microscopy. , 1997, Chemistry & biology.

[165]  D. Thal,et al.  Differential pattern of β-amyloid, amyloid precursor protein and apolipoprotein E expression in cortical senile plaques , 1997, Acta Neuropathologica.

[166]  P. Lansbury,et al.  Models of amyloid seeding in Alzheimer's disease and scrapie: mechanistic truths and physiological consequences of the time-dependent solubility of amyloid proteins. , 1997, Annual review of biochemistry.

[167]  Peter T. Lansbury,et al.  Observation of metastable Aβ amyloid protofibrils by atomic force microscopy , 1997 .

[168]  D. Graham,et al.  Is beta-APP a marker of axonal damage in short-surviving head injury? , 1996, Acta neuropathologica.

[169]  D. Mann,et al.  Dominant and differential deposition of distinct beta-amyloid peptide species, A beta N3(pE), in senile plaques. , 1995, Neuron.

[170]  T. Iwatsubo,et al.  Visualization of A beta 42(43) and A beta 40 in senile plaques with end-specific A beta monoclonals: evidence that an initially deposited species is A beta 42(43). , 1994, Neuron.

[171]  K. Grzeschik,et al.  The precursor of Alzheimer??s disease amyloid A4 protein resembles a cell-surface receptor , 1987 .

[172]  G. Glenner,et al.  Alzheimer's disease: initial report of the purification and characterization of a novel cerebrovascular amyloid protein. , 1984, Biochemical and biophysical research communications.

[173]  H. M. Zimmerman Progress in neuropathology , 1971 .

[174]  A. Alzheimer Uber eine eigenartige Erkrankung der Hirnrinde , 1907 .

[175]  D. Wilcock,et al.  Sanders-brown Center on Aging Faculty Publications Aging Transition from an M1 to a Mixed Neuroinflammatory Phenotype Increases Amyloid Deposition in App/ps1 Transgenic Mice Repository Citation Transition from an M1 to a Mixed Neuroinflammatory Phenotype Increases Amyloid Deposition in App/ps1 Trans , 2022 .